Abstract In recent years, high-sensitivity cardiac troponin T (hs-cTnT) has been recognized as an effective marker for myocardial injury in adults and can be used to diagnose acute myocardial injury and predict major adverse cardiovascular events. It is the gold standard for the diagnosis of acute myocardial infarction in adults. Neonates are a special group, and due to the changes of various physiological processes during the perinatal period, many laboratory markers used in adults may have a low clinical value in neonates. So far, for example, there is still no suitable cardiac serum biomarker that can reflect the true condition of neonatal myocardial injury. In recent years, new breakthroughs have been made in the application of hs-cTnT in the field of neonates. In order to fully understand the role of hs-cTnT in neonatal diseases, this article reviews the research advances in the biological and physiological features of hs-cTnT and its application in neonates.
Julie S, John M, Federica B, et al. Cardiac troponin and its relationship to cardiovascular outcomes in community populations-a systematic review and meta-analysis[J]. Heart Lung Circ, 2016, 25(3):217-228.
[2]
Moritz B, Evangelos G, Manuel K, et al. Prognostic value of high-sensitivity cardiac troponin T compared to riskscores in stable cardiovascular disease[J]. Am J Med, 2017, 130(5):572-582.
[3]
Beata M, Stephane F, Maxime T, et al. Performance of highly sensitive cardiac troponin T assay to detect ischaemia at PET-CT in low-risk patients with acute coronary syndrome:a prospective observational study[J]. BMJ Open, 2017, 7(7):e014655.
[4]
Park KC, Gaze DC, Collinson PO, et al. Cardiac troponins:from myocardial infarction to chronic disease[J]. Cardiovasc Res, 2017, 113(14):1708-1718.
[5]
Greaser ML, Gergely J. Purification and properties of the components from troponin[J]. J Biol Chem, 1973, 248(6):2125-2133.
[6]
Francesco B, Leonarda G, Davide M, et al. Comparison of diagnostic accuracy between three different rules of interpreting high sensitivity troponin T results[J]. Intern Emerg Med, 2012, 7(4):365-370.
[7]
Li X, Luo R, Jiang R, et al. The prognostic use of serum concentrations of cardiac troponin-I, CK-MB and myoglobin in patients with idiopathic dilated cardiomyopathy[J]. Heart Lung, 2014, 43(3):219-224.
[8]
Fred S, Yader S, Allan S, et al. Cardiac troponin assays:guide to understanding analytical characteristics and their impact on clinical care[J]. Clin Chem, 2017, 63(1):73-81.
[9]
Kozinski M, Krintus M, Kubica J, et al. High-sensitivity cardiac troponin assays:from improved analytical performance to enhanced risk stratification[J]. Crit Rev Clin Lab Sci, 2017, 54(3):143-172.
[10]
Sayadnik M, Shafiee A, Jenab Y, et al. Predictors of high sensitivity cardiac troponin T elevation in patients with acute paroxysmal supraventricular tachycardia and ischemic heart disease[J]. Tex Heart Inst J, 2017, 44(5):306-311.
[11]
Bergenzaun L, Ohlin H, Gudmundsson P, et al. High-sensitive cardiac troponin T is superior to echocardiography in predicting 1-year mortality in patients with SIRS and shock in intensive care[J]. BMC Anesthesiol, 2012, 12:25.
[12]
Völkers M, Rohde D, Zelniker T, et al. High-sensitive troponin T increase after exercise in patients with pulmonary arterial hypertension[J]. BMC Pulm Med, 2013, 13:28.
[13]
McEvoy JW, Chen Y, Nambi V, et al. High-sensitivity cardiac troponin T and risk of hypertension[J]. Circulation, 2015, 132(9):825-833.
[14]
Sun L, Ji Y, Wang Y, et al. High-sensitive cardiac troponin T:a biomarker of left-ventricular diastolic dysfunction in hemodialysis patients[J]. J Nephrol, 2018, 31(6):967-973.
[15]
Iqbal N, Wentworth B, Choudhary R, et al. Cardiac biomarkers:new tools for heart failure management[J]. Cardiovasc Diagn Ther, 2012, 2(2):147-164.
[16]
Buiten MS, de Bie MK, Rotmans JI, et al. Serum cardiac troponin-I is superior to troponin-T as a marker for left ventricular dysfunction in clinically stable patients with end-stage renal disease[J]. PLoS One, 2015, 10(8):e0134245.
[17]
Aimo A, Januzzi JL Jr, Vergaro G, et al. High-sensitivity troponin T, NT-proBNP and glomerular filtration rate:a multimarker strategy for risk stratification in chronic heart failure[J]. Int J Cardiol, 2019, 277:166-172.
[18]
Neukamm AM, Høiseth AD, Hagve TA, et al. High-sensitivity cardiac troponin T levels are increased in stable COPD[J]. Heart, 2013, 99(6):382-387.
[19]
Turkmen S, Askin L, Uzel KE, et al. Association of high-sensitivity troponin T with left ventricular dysfunction in ankylosing spondylitis[J]. J Clin Rheumatol, 2018. doi:10.1097/RHU.0000000000000951.[Epub ahead of print]
[20]
Cruz MA, Bremmer YA, Porter BO, et al. Cardiac troponin T and cardiac dysfunction in extremely low-birth-weight infants[J]. Pediatr Cardiol, 2006, 27(4):396-401.
[21]
Valo M, Wons A, Moeller A, et al. Markers of myocardial ischemia in patients with obstructive sleep apnea and coronary artery disease[J]. Pulm Med, 2015, 2015:621450.
[22]
Sandoval Y, Jaffe AS. Using high-sensitivity cardiac troponin T for acute cardiac care[J]. Am J Med, 2017, 130(12):1358-1365.e1.
[23]
van der Linden N, Klinkenberg LJ, Bekers O, et al. Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population[J]. Medicine (Baltimore), 2016, 95(52):e5703.
[24]
Aimo A, Januzzi JL Jr, Vergaro G, et al. Prognostic value of high-sensitivity troponin T in chronic heart failure:an individual patient data meta-analysis[J]. Circulation, 2018, 137(3):286-297.
[25]
Hoff J, Wehner W, Nambi V. Troponin in cardiovascular disease prevention:updates and future direction[J]. Curr Atheroscler Rep, 2016, 18(3):12.
[26]
Kopec M, Duma A, Helwani MA, et al. Improving prediction of postoperative myocardial infarction with high-sensitivity cardiac troponin T and NT-proBNP[J]. Anesth Analg, 2017, 124(2):398-405.
[27]
Twerenbold R, Boeddinghaus J, Nestelberger T, et al. Clinical use of high-sensitivity cardiac troponin in patients with suspected myocardial infarction[J]. J Am Coll Cardiol, 2017, 70(8):996-1012.
[28]
Alquézar-Arbé A, Sionis A, Ordoñez-Llanos J, et al. Cardiac troponins:25 years on the stage and still improving their clinical value[J]. Crit Rev Clin Lab Sci, 2017, 54(7-8):551-571.
[29]
Asrani P, Aly AM, Jiwani AK, et al. High-sensitivity troponin T in preterm infants with a hemodynamically significant patent ductus arteriosus[J]. J Perinatol, 2018, 38(11):1483-1489.
[30]
Sherwood MW, Kristin Newby L. High-sensitivity troponin assays:evidence, indications, and reasonable use[J]. J Am Heart Assoc, 2014, 3(1):e000403.
[31]
Chenevier-Gobeaux C, Bonnefoy-Cudraz É, Charpentier S, et al. High-sensitivity cardiac troponin assays:answers to frequently asked questions[J]. Arch Cardiovasc Dis, 2015, 108(2):132-149.
[32]
Jehlicka P, Huml M, Rajdl D, et al. How to interpret elevated plasmatic level of high-sensitive troponin T in newborns and infants?[J]. Physiol Res, 2018, 67(2):191-195.
[33]
Neves AL, Henriques-Coelho T, Leite-Moreira A, et al. Cardiac injury biomarkers in paediatric age:are we there yet?[J]. Heart Fail Rev, 2016, 21(6):771-781.
[34]
Sandoval Y, Smith SW, Apple FS, et al. Present and future of cardiac troponin in clinical practice:a paradigm shift to high-sensitivity assays[J]. Am J Med, 2016, 129(4):354-365.
[35]
Keselman B, Vergara M, Nyberg S, et al. A randomized cross-over study of the acute effects of running 5 km on glucose, insulin, metabolic rate, cortisol and troponin T[J]. PLoS One, 2017, 12(6):e0179401.
[36]
Wang J, Ji W, Xu Z, et al. Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis[J]. Exp Ther Med, 2016, 11(1):154-156.
[37]
Sadoh WE, Eregie CO, Nwaneri DU, et al. The diagnostic value of both troponin T and creatinine kinase isoenzyme (CK-MB) in detecting combined renal and myocardial injuries in asphyxiated infants[J]. PLoS One, 2014, 9(3):e91338.
[38]
Correale M, Nunno L, Ieva R, et al. Troponin in newborns and pediatric patients[J]. Cardiovasc Hematol Agents Med Chem, 2009, 7(4):270-278.
[39]
Kluckow M, Lemmers P. Hemodynamic assessment of the patent ductus arteriosus:beyond ultrasound[J]. Semin Fetal Neonatal Med, 2018, 23(4):239-244.
[40]
Türker G, Babaoğlu K, Gökalp AS, et al. Cord blood cardiac troponin I as an early predictor of short-term outcome in perinatal hypoxia[J]. Biol Neonate, 2004, 86(2):131-137.
[41]
Neukamm A, Einvik G, Didrik Høiseth A, et al. The prognostic value of measurement of high-sensitive cardiac troponin T for mortality in a cohort of stable chronic obstructive pulmonary disease patients[J]. BMC Pulm Med, 2016, 16(1):164.
