SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate
WANG Jin, WANG Dan, CHEN Guo-Ce, TAO Xu-Wei, ZENG Ling-Kong
Wuhan Children's Hospital/Wuhan Maternal and Child Healthcare Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China
Abstract Since December 2019, the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has occurred in Wuhan, Hubei Province, China. The infected cases were noted mostly in adults, but rarely reported in children, especially neonates. Most children with SARS-CoV-2 infection present mainly with respiratory symptoms, but less commonly with gastrointestinal symptoms, and tend to have mild clinical symptoms. A neonate with SARS-CoV-2 infection, who had vomiting and milk refusal as the first symptom, was recently admitted to Wuhan Children's Hospital. After two weeks of treatment, the patient recovered gradually and was discharged. Here, this case is reported to improve the understanding of SARS-CoV-2 infection in neonates.
WANG Jin,WANG Dan,CHEN Guo-Ce et al. SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate[J]. CJCP, 2020, 22(3): 211-214.
WANG Jin,WANG Dan,CHEN Guo-Ce et al. SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate[J]. CJCP, 2020, 22(3): 211-214.
Wei M, Yuan J, Liu Y, et al. Novel coronavirus infection in hospitalized infants under 1 year of age in China[J]. JAMA, 2020. DOI:10.1001/jama.2020.2131. Epub ahead of print.
World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected (interim guidance)[EB/OL]. (2020-01-28)[2020-02-16]. https://www.who.int/publications-detail/clinicalmanagement-of-severe-acute-respiratory-infection-when-novelcoronavirus-(ncov)-infection-is-suspected.
[11]
Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019[J]. N Engl J Med, 2020, 382(8):727-733.
[12]
Chen Y, Liu Q, Guo D. Emerging coronavirus:genome structure, replication, and pathogenesis[J]. J Med Virol, 2020, 92(4):418-423.
[13]
Zhang H, Kang ZJ, Gong HY, et al. The digestive system is a potential route of 2019-nCoV infection:a bioinformatics analysis based on single-cell transcriptomes[J/OL]. BioRxiv. (2020-01-31)[2020-02-16]. https://www.biorxiv.org/content/10.1101/2020.01.30.927806v1?from=singlemessage.
[14]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020, 395(10223):497-506.
[15]
Chan JF, Yuan S, Kok KH, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating personto-person transmission:a study of a family cluster[J]. Lancet, 2020, 395(10223):514-523.
