Abstract Preeclampsia (PE) is a unique complication of pregnancy that affects the health of the mother and the infant. Intestinal flora plays an important regulatory role in human body's metabolism and immunity and is associated with many diseases. Studies have shown that the development and progression of PE can lead to alterations in intestinal flora in the mother and are even closely associated with the colonization and development of intestinal flora in the offspring. This article reviews related studies on the effect of PE on maternal-infant intestinal flora, so as to provide new ideas for the prevention and treatment of maternal and infant complications associated with PE.
von Ehr J, von Versen-H?ynck F. Implications of maternal conditions and pregnancy course on offspring's medical problems in adult life[J]. Arch Gynecol Obstet, 2016, 294(4): 673-679. PMID: 27522600. DOI: 10.1007/s00404-016-4178-7.
Aatsinki AK, Uusitupa HM, Munukka E, et al. Gut microbiota composition in mid-pregnancy is associated with gestational weight gain but not prepregnancy body mass index[J]. J Womens Health (Larchmt), 2018, 27(10): 1293-1301. PMID: 29757063. PMCID: PMC6205042. DOI: 10.1089/jwh.2017.6488.
Liu J, Yang H, Yin Z, et al. Remodeling of the gut microbiota and structural shifts in preeclampsia patients in South China[J]. Eur J Clin Microbiol Infect Dis, 2017, 36(4): 713-719. PMID: 27988814. DOI: 10.1007/s10096-016-2853-z.
Chen X, Li P, Liu M, et al. Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation[J]. Gut, 2020, 69(3): 513-522. PMID: 31900289. DOI: 10.1136/gutjnl-2019-319101.
Gomez-Arango LF, Barrett HL, McIntyre HD, et al. Increased systolic and diastolic blood pressure is associated with altered gut microbiota composition and butyrate production in early pregnancy[J]. Hypertension, 2016, 68(4): 974-981. PMID: 27528065. DOI: 10.1161/HYPERTENSIONAHA.116.07910.
Ahmadian E, Rahbar Saadat Y, Hosseiniyan Khatibi SM, et al. Pre-eclampsia: microbiota possibly playing a role[J]. Pharmacol Res, 2020, 155: 104692. PMID: 32070720. DOI: 10.1016/j.phrs.2020.104692.
Eghbal-Fard S, Yousefi M, Heydarlou H, et al. The imbalance of Th17/Treg axis involved in the pathogenesis of preeclampsia[J]. J Cell Physiol, 2019, 234(4): 5106-5116. PMID: 30277561. DOI: 10.1002/jcp.27315.
Janeiro MH, Ramírez MJ, Milagro FI, et al. Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target[J]. Nutrients, 2018, 10(10): 1398. PMID: 30275434. PMCID: PMC6213249. DOI: 10.3390/nu10101398.
Sun BM, Meng L, Liu H, et al. Changes in intestinal flora in preeclampsia rats and effects of probiotics on their inflammation and blood pressure[J]. Eur Rev Med Pharmacol Sci, 2020, 24(19): 10155-10161. PMID: 33090423. DOI: 10.26355/eurrev_202010_23235.
Brantsaeter AL, Myhre R, Haugen M, et al. Intake of probiotic food and risk of preeclampsia in primiparous women: the Norwegian mother and child cohort study[J]. Am J Epidemiol, 2011, 174(7): 807-815. PMID: 21821542. PMCID: PMC3203379. DOI: 10.1093/aje/kwr168.
Nordqvist M, Jacobsson B, Brants?ter AL, et al. Timing of probiotic milk consumption during pregnancy and effects on the incidence of preeclampsia and preterm delivery: a prospective observational cohort study in Norway[J]. BMJ Open, 2018, 8(1): e018021. PMID: 29362253. PMCID: PMC5780685. DOI: 10.1136/bmjopen-2017-018021.
Milani C, Duranti S, Bottacini F, et al. The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota[J]. Microbiol Mol Biol Rev, 2017, 81(4): e00036-17. PMID: 29118049. PMCID: PMC5706746. DOI: 10.1128/MMBR.00036-17.
Collado MC, Isolauri E, Laitinen K, et al. Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy[J]. Am J Clin Nutr, 2010, 92(5): 1023-1030. PMID: 20844065. DOI: 10.3945/ajcn.2010.29877.
Liu HQ, Redline RW, Han YW. Fusobacterium nucleatum induces fetal death in mice via stimulation of TLR4-mediated placental inflammatory response[J]. J Immunol, 2007, 179(4): 2501-2508. PMID: 17675512. DOI: 10.4049/jimmunol.179.4.2501.
Amarasekara R, Jayasekara RW, Senanayake H, et al. Microbiome of the placenta in pre-eclampsia supports the role of bacteria in the multifactorial cause of pre-eclampsia[J]. J Obstet Gynaecol Res, 2015, 41(5): 662-669. PMID: 25492799. DOI: 10.1111/jog.12619.
Kaduma J, Seni J, Chuma C, et al. Urinary tract infections and preeclampsia among pregnant women attending two hospitals in Mwanza city, Tanzania: a 1:2 matched case-control study[J]. Biomed Res Int, 2019, 2019: 3937812. PMID: 31032344. PMCID: PMC6457296. DOI: 10.1155/2019/3937812.
Chang YL, Chen YY, Zhou Q, et al. Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia[J]. Clin Sci (Lond), 2020, 134(2): 289-302. PMID: 31961431. DOI: 10.1042/CS20191253.
Zhang W, Ma C, Xie P, et al. Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and different taxonomic abundances[J]. J Appl Microbiol, 2019, 127(2): 354-369. PMID: 31077497. PMCID: PMC6916403. DOI: 10.1111/jam.14304.