Assessment of myocardial injury in neonates born to pregnant women with pregnancy complicated by severe preeclampsia by myocardial work indices: a prospective study
CHEN Hui-Yun, PAN Tao, LI Hong, XU Qiu-Qin, SUN Fang-Can, HAN Bing, GU Xin-Xian
Department of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, China
Abstract Objectives To evaluate myocardial injury in neonates born to pregnant women with pregnancy complicated by severe preeclampsia by myocardial work indices. Methods A prospective cohort study was performed on 25 preterm infants born to the pregnant women with severe preeclampsia from June 2020 to April 2021 (severe preeclampsia group), and 25 preterm infants born to the pregnant women without severe complications in pregnancy were enrolled as the control group. Echocardiography was performed within 24 hours and at 48-72 hours and 14-28 days after birth to measure conventional parameters. Two-dimensional speckle-tracking echocardiography was performed to construct a noninvasive left ventricular pressure-strain loop based on two-dimensional myocardial strain and left ventricular systolic pressure noninvasively measured, so as to calculate myocardial work indices. Results Compared with the control group, the severe preeclampsia group had significant reductions in left ventricular global work index and global constructive work within 24 hours after birth (P<0.05), a significant reduction in left ventricular global work efficiency and a significant increase in global waste work at 48-72 hours after birth (P<0.05), and a significant reduction in left ventricular global work efficiency at 14-28 days after birth (P<0.05). Conclusions Subclinical myocardial injury persists in the neonatal period in preterm infants born to pregnant women with severe preeclampsia.
CHEN Hui-Yun,PAN Tao,LI Hong et al. Assessment of myocardial injury in neonates born to pregnant women with pregnancy complicated by severe preeclampsia by myocardial work indices: a prospective study[J]. CJCP, 2022, 24(2): 155-161.
CHEN Hui-Yun,PAN Tao,LI Hong et al. Assessment of myocardial injury in neonates born to pregnant women with pregnancy complicated by severe preeclampsia by myocardial work indices: a prospective study[J]. CJCP, 2022, 24(2): 155-161.
Armstrong DWJ, Tse MY, Wong PG, et al. Gestational hypertension and the developmental origins of cardiac hypertrophy and diastolic dysfunction[J]. Mol Cell Biochem, 2014, 391(1-2): 201-209. PMID: 24718734. DOI: 10.1007/s11010-014-2003-9.
Russell K, Eriksen M, Aaberge L, et al. A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work[J]. Eur Heart J, 2012, 33(6): 724-733. PMID: 22315346. PMCID: PMC3303715. DOI: 10.1093/eurheartj/ehs016.
Chan J, Edwards NFA, Khandheria BK, et al. A new approach to assess myocardial work by non-invasive left ventricular pressure-strain relations in hypertension and dilated cardiomyopathy[J]. Eur Heart J Cardiovasc Imaging, 2019, 20(1): 31-39. PMID: 30247622. DOI: 10.1093/ehjci/jey131.
Edwards NFA, Scalia GM, Shiino K, et al. Global myocardial work is superior to global longitudinal strain to predict significant coronary artery disease in patients with normal left ventricular function and wall motion[J]. J Am Soc Echocardiogr, 2019, 32(8): 947-957. PMID: 31043359. DOI: 10.1016/j.echo.2019.02.014.
Vecera J, Penicka M, Eriksen M, et al. Wasted septal work in left ventricular dyssynchrony: a novel principle to predict response to cardiac resynchronization therapy[J]. Eur Heart J Cardiovasc Imaging, 2016, 17(6): 624-632. PMID: 26921169. PMCID: PMC4871236. DOI: 10.1093/ehjci/jew019.
Du Bois D, Du Bois EF. A formula to estimate the approximate surface area if height and weight be known. 1916[J]. Nutrition, 1989, 5(5): 303-311; discussion 312-313. PMID: 2520314.
Lopez L, Colan SD, Frommelt PC, et al. Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council[J]. J Am Soc Echocardiogr, 2010, 23(5): 465-495. PMID: 20451803. DOI: 10.1016/j.echo.2010.03.019.
Tsutsumi T, Ishii M, Eto G, et al. Serial evaluation for myocardial performance in fetuses and neonates using a new Doppler index[J]. Pediatr Int, 1999, 41(6): 722-727. PMID: 10618901. DOI: 10.1046/j.1442-200x.1999.01155.x.
Youssef L, Miranda J, Paules C, et al. Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction[J]. Am J Obstet Gynecol, 2020, 222(1): 79.e1-79.e9. PMID: 31336074. DOI: 10.1016/j.ajog.2019.07.025.
Mutlu K, Karadas U, Yozgat Y, et al. Echocardiographic evaluation of cardiac functions in newborns of mildly preeclamptic pregnant women within postnatal 24-48 hours[J]. J Obstet Gynaecol, 2018, 38(1): 16-21. PMID: 28631496. DOI: 10.1080/01443615.2017.1322564.
SHEN Wei, ZHENG Zhi, LIN Xin-Zhu, WU Fan, TIAN Qian-Xin, CUI Qi-Liang, YUAN Yuan, REN Ling, MAO Jian, SHI Bi-Zhen, WANG Yu-Mei, LIU Ling, ZHANG Jing-Hui, CHANG Yan-Mei, TONG Xiao-Mei, ZHU Yan, ZHANG Rong, YE Xiu-Zhen, ZOU Jing-Jing, LI Huai-Yu, ZHAO Bao-Yin, QIU Yin-Ping, LIU Shu-Hua, MA Li, XU Ying, CHENG Rui, ZHOU Wen-Li, WU Hui, LIU Zhi-Yong, CHEN Dong-Mei, GAO Jin-Zhi, LIU Jing, CHEN Ling, LI Cong, YANG Chun-Yan, XU Ping, ZHANG Ya-Yu, HU Si-Le, MEI Hua, YANG Zu-Ming, FENG Zong-Tai, WANG San-Nan, MENG Er-Yan, SHANG Li-Hong, XU Fa-Lin, OU Shao-Ping, JU Rong. Incidence of extrauterine growth retardation and its risk factors in very preterm infants during hospitalization: a multicenter prospective study[J]. CJCP, 2022, 24(2): 132-140.
