预防性使用水解蛋白配方奶对早产儿胃肠道疾病及体格生长影响的Meta分析

doi:10.7499/j.issn.1008-8830.2109124

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Abstract Objective To systematically evaluate the effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical development in preterm infants. Methods A computerized search was performed in the databases including China National Knowledge Infrastructure, Wanfang Data, Weipu, PubMed, Embase, and the Cochrane Library to identify randomized controlled trials of the effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical growth in preterm infants. RevMan 5.3 software was used to perform a Meta analysis for the included studies. Results A total of 7 randomized controlled studies were included. The results of Meta analysis showed that compared with the whole protein formula, the prophylactic use of hydrolyzed protein formula could reduce the risk of neonatal necrotizing enterocolitis (RR=0.40, P=0.04) and feeding intolerance (RR=0.40, P=0.005), and had no significant effect on the growth of weight, length and head circumference (P>0.05). Conclusions Compared with the whole protein formula, the prophylactic use of hydrolyzed protein formula in preterm infants may reduce the occurrence of necrotizing enterocolitis and feeding intolerance, and can meet the nutrient requirement of physical development. However, the evidence is limited, and the results of this study cannot support the routine prophylactic use of hydrolyzed protein formula in preterm infants.

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	Articles by authors
	XIANG Ling-Ling
	HU Yuan-Yuan
	XIA Xu-Hua
	HUA Zi-Yu

Key words： Hydrolyzed protein formula Necrotizing enterocolitis Feeding intolerance Physical growth Meta analysis Preterm infant

Received: 22 September 2021

Cite this article:

XIANG Ling-Ling,HU Yuan-Yuan,XIA Xu-Hua et al. Effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical growth in preterm infants: a Meta analysis[J]. CJCP, 2022, 24(2): 169-175.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2109124 OR http://www.zgddek.com/EN/Y2022/V24/I2/169

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