超早产儿/超低出生体重儿临床结局的性别差异：一项倾向性评分匹配研究

doi:10.7499/j.issn.1008-8830.2201049

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Abstract Objective To study the effect of sex on the clinical outcome of extremely preterm infants (EPIs)/extremely low birth weight infants (ELBWIs) by propensity score matching. Methods A retrospective analysis was performed for the medical data of 731 EPIs or ELBWIs who were admitted from January 1, 2011 to December 31, 2020. These infants were divided into two groups: male and female. A propensity score matching analysis was performed at a ratio of 1:1. The matching variables included gestational age, birth weight, percentage of withdrawal from active treatment, percentage of small-for-gestational-age infant, percentage of use of pulmonary surfactant, percentage of 1-minute Apgar score ≤3, percentage of mechanical ventilation, duration of mechanical ventilation, percentage of antenatal use of inadequate glucocorticoids, and percentage of hypertensive disorders in pregnancy. The two groups were compared in the incidence rate of main complications during hospitalization and the rate of survival at discharge. Results Before matching, compared with the female group, the male group had significantly higher incidence rates of neonatal respiratory distress syndrome, bronchopulmonary dysplasia (BPD), severe intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, and patent ductus arteriosus (P<0.05), while after matching, the male group only had a significantly higher incidence rate of BPD than the female group (P<0.05). There was no significant difference in the rate of survival at discharge between the two groups before and after matching (P>0.05). Conclusions Male EPIs/ELBWIs have a higher risk of BPD than female EPIs/ELBWIs, but male and female EPIs/ELBWIs tend to have similar outcomes. Citation:Chinese Journal of Contemporary Pediatrics, 2022, 24(5): 514-520

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	Articles by authors
	SU Zhi-Wen
	LIN Li-Li
	SHI Bi-Jun
	HUANG Xiao-Xia
	WEI Jian-Wei
	JIA Chun-Hong
	WU Fan
	CUI Qi-Liang

Key words： Sex Clinical outcome Propensity score matching Extremely preterm infant Extremely low birth weight infant

Received: 14 January 2022

Cite this article:

SU Zhi-Wen,LIN Li-Li,SHI Bi-Jun et al. Sex differences in clinical outcomes of extremely preterm infants/extremely low birth weight infants: a propensity score matching study[J]. CJCP, 2022, 24(5): 514-520.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2201049 OR http://www.zgddek.com/EN/Y2022/V24/I5/514

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