11岁女孩反复全身散在皮疹10年

doi:10.7499/j.issn.1008-8830.2204123

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Abstract A girl, aged 11 years, was admitted due to recurrent rash on the whole body and mucosa for 10 years, and typical rash was erythema at the perioral region, hand-foot joints, vulva, and perianal region, with blisters, erosions, and ulcers on the erythema. The girl was improved after zinc supplementation. Her younger brother had similar rash and medical history. The histopathological examination showed epidermal parakeratosis with mild hyperkeratosis, severe spongiform edema of the stratum corneum, significant proliferation of acanthocytes, and vacuolation of keratinocytes. The genetic testing revealed that both the girl and her younger brother had a homozygous mutation of c.1456(exon9)delG in the SLC39A4 gene, and thus the girl was diagnosed with acrodermatitis enteropathica. It is concluded that for children with recurrent rash on the limbs and at the perioral region, genetic testing should be performed as early as possible to make a confirmed diagnosis, and a sufficient dose of zinc supplementation should be given, while the levels of trace elements such as blood zinc should be regularly monitored. Citation:Chinese Journal of Contemporary Pediatrics, 2022, 24(9): 1047-1052

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	LI Ke-Yao
	TANG Jian-Ping
	SHU Ye
	YUE Shu-Zhen
	WANG Yu-Wei
	WEN Rong
	ZHOU Bin

Key words： Acrodermatitis enteropathica SLC39A4 Gene mutation Child

Received: 19 April 2022

Cite this article:

LI Ke-Yao,TANG Jian-Ping,SHU Ye et al. Recurrent systemic sporadic rash for 10 years in a girl aged 11 years[J]. CJCP, 2022, 24(9): 1047-1052.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2204123 OR http://www.zgddek.com/EN/Y2022/V24/I9/1047

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