长春新碱诱导的周围神经病变的儿童队列研究

doi:10.7499/j.issn.1008-8830.2212032

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Abstract Objective To study the characteristics of vincristine-induced peripheral neuropathy (VIPN) in children with acute lymphoblastic leukemia (ALL) and the factors influencing the development of VIPN. Methods The children with ALL, aged 1-18 years, who were treated with CCCG-ALL2015 or CCCG-ALL2020 regimen in the Affiliated Hospital of Guizhou Medical University from January 2018 to February 2022 were enrolled as subjects. According to the influence of age on risk, the children were divided into 1-10 years group with 91 children and >10 years group with 29 children. VIPN was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (5th edition), and the incidence rate, severity, and type of VIPN were compared between different groups. Results A total of 120 children were enrolled in this study, among whom 56 (46.7%) developed VIPN. The >10 years group had a significantly higher incidence rate of VIPN than the 1-10 years group (69% vs 40%, P<0.05). Among the 56 children with VIPN, 12 (21%) had grade 3 VIPN or above, and 44 (79%) had grade 2 VIPN. There were 77 cases of autonomic nerve symptoms (59.7%), 42 cases of peripheral nerve injury (32.5%), and 10 cases of cranial nerve injury (7.8%). There were no significant differences in the severity and type of VIPN between the groups with different ages, sexes, degrees of risk, or treatment regimens (P>0.05). The results of binary logistic regression analysis showed that age is the influencing factor for the occurrence of VIPN (P>0.05). Conclusions There is a relatively high incidence rate of VIPN in children with ALL, with the highest incidence rate of autonomic nervous symptoms. The incidence of VIP in children over 10 years old is relatively high.

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	LI Chuang
	JIN Jiao
	HUANG Jing
	YANG Xiao-Yan
	LI Yan
	YAN Yong-Yan
	YANG Can

Key words： Acute lymphoblastic leukemia Vincristine Peripheral neuropathy Child

Received: 07 December 2022

Corresponding Authors: Jin J, Email:jinjiao999@gmc.edu.cn E-mail: jinjiao999@gmc.edu.cn

Cite this article:

LI Chuang,JIN Jiao,HUANG Jing et al. A cohort study of vincristine-induced peripheral neuropathy in children[J]. CJCP, 2023, 25(5): 470-475.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2212032 OR http://www.zgddek.com/EN/Y2023/V25/I5/470

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