Recent research on platelet-leukocyte aggregates and their role in the pathogenesis of Kawasaki disease

GAO Li-Chao, GONG Fang-Qi

Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (6) : 587-594.

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (6) : 587-594. DOI: 10.7499/j.issn.1008-8830.2302066
TOPIC OF KAWASAKI DISEASE

Recent research on platelet-leukocyte aggregates and their role in the pathogenesis of Kawasaki disease

  • GAO Li-Chao, GONG Fang-Qi
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Abstract

Activated platelets may interact with various types of leukocytes such as monocytes, neutrophils, dendritic cells, and lymphocytes, trigger intercellular signal transduction, and thus lead to thrombosis and synthesis of massive inflammatory mediators. Elevated levels of circulating platelet-leukocyte aggregates have been found in patients with thrombotic or inflammatory diseases. This article reviews the latest research on the formation, function, and detection methods of platelet-leukocyte aggregates and their role in the onset of Kawasaki disease, so as to provide new ideas for studying the pathogenesis of Kawasaki disease.

Key words

Kawasaki disease / Platelet-leukocyte aggregate / Antiplatelet agent / Coronary artery ectasia

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GAO Li-Chao, GONG Fang-Qi. Recent research on platelet-leukocyte aggregates and their role in the pathogenesis of Kawasaki disease[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(6): 587-594 https://doi.org/10.7499/j.issn.1008-8830.2302066

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