维生素D在克罗恩病中的作用机制及外源性补充作用

doi:10.7499/j.issn.1008-8830.2212064

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Abstract Vitamin D can not only regulate calcium and phosphorus metabolism, but also exert an immunoregulatory effect. Vitamin D deficiency is common in patients with Crohn's disease (CD). Studies have shown that vitamin D is associated with CD and other autoimmune diseases and can improve the condition of patients with CD and promote their recovery by regulating intestinal immunity, repairing the intestinal mucosal barrier, inhibiting intestinal fibrosis, enhancing the response to infliximab, and regulating intestinal microbiota. Exogenous vitamin D supplementation can induce disease remission while increasing the serum level of vitamin D. However, only a few randomized, double-blind, and placebo-controlled trials have investigated the therapeutic effect of vitamin D in CD, and the optimal form of vitamin D supplementation, the specific dosage of vitamin D supplementation, and the optimal serum maintenance concentration of vitamin D remain to be clarified. This article mainly discusses the mechanism of action of vitamin D in CD and the beneficial effect of exogenous vitamin D supplementation on CD.

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	XIA Yu
	ZHOU Juan
	ZHAO Hong-Mei
	YOU Jie-Yu

Key words： Crohn's disease Vitamin D Mechanism of action Child

Received: 14 December 2022

Corresponding Authors: (You J-Y , Email:yjy660111@sina.com) E-mail: yjy660111@sina.com

Cite this article:

XIA Yu,ZHOU Juan,ZHAO Hong-Mei et al. Mechanism of action and exogenous supplementation of vitamin D in Crohn's disease[J]. CJCP, 2023, 25(8): 870-876.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2212064 OR http://www.zgddek.com/EN/Y2023/V25/I8/870

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