Recent research on the relationship between pulmonary microbiome and asthma endotypes in children
LI Jing-Yan
Department of Neonatology, the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University/Huai'an Key Laboratory of Diagnosis and Treatment of Pediatric Respiratory Diseases, Huai'an, Jiangsu 223300, China
Abstract Bronchial asthma is not considered a singular disease, but rather a collection of syndromes with multiple phenotypes and mechanisms that involve various signaling pathways. It typically emerges during the preschool years, and its etiology is intricate and diverse. In recent years, the advancement of high-throughput sequencing technology has revealed that early alterations in lung microbiota may be associated with asthma incidence and progression. Moreover, significant variations in lung microbiota have been observed among different airway inflammation profiles, known as asthma endotypes. Hence, a comprehensive understanding of the characteristics of lung microbiota in children with asthma can aid in managing disease progression and improving long-term prognosis. Additionally, such insights may spark novel approaches to diagnosing and treating childhood asthma.
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