12例狼疮性肾炎合并血栓性微血管病变临床特点及预后分析

doi:10.7499/j.issn.1008-8830.2306029

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Abstract Objective To investigate the clinical characteristics, pathological features, treatment regimen, and prognosis of children with lupus nephritis (LN) and thrombotic microangiopathy (TMA), as well as the treatment outcome of these children and the clinical and pathological differences between LN children with TMA and those without TMA. Methods A retrospective analysis was conducted on 12 children with LN and TMA (TMA group) who were admitted to the Department of Nephrology, Children's Hospital of Nanjing Medical University, from December 2010 to December 2021. Twenty-four LN children without TMA who underwent renal biopsy during the same period were included as the non-TMA group. The two groups were compared in terms of clinical manifestations, laboratory examination results, and pathological results. Results Among the 12 children with TMA, 8 (67%) had hypertension and 3 (25%) progressed to stage 5 chronic kidney disease. Compared with the non-TMA group, the TMA group had more severe tubulointerstitial damage, a higher Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score at onset, and higher cholesterol levels (P<0.05). There were no significant differences between the two groups in the percentage of crescent bodies and the levels of hemoglobin and platelets (P>0.05). Conclusions There is a higher proportion of individuals with hypertension among the children with LN and TMA, as well as more severe tubulointerstitial damage. These children have a higher SLEDAI score and a higher cholesterol level.

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	CHENG Xue-Qin
	ZHAO Fei
	DING Gui-Xia
	ZHAO San-Long
	CHEN Qiu-Xia
	ZHU Chun-Hua

Key words： Lupus nephritis Thrombotic microangiopathy Clinical characteristic Child

Received: 07 June 2023

Cite this article:

CHENG Xue-Qin,ZHAO Fei,DING Gui-Xia et al. Clinical characteristics and prognosis of 12 cases of lupus nephritis complicated with thrombotic microangiopathy[J]. CJCP, 2023, 25(11): 1118-1123.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2306029 OR http://www.zgddek.com/EN/Y2023/V25/I11/1118

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