Multisystem inflammatory syndrome in children in the context of coronavirus disease 2019 pandemic

ZHOU Bin; HUANG Yu-Kun; HONG Shao-Xian; JIAO Fu-Yong; XIE Kai-Sheng

doi:10.7499/j.issn.1008-8830.2306093

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Chinese Journal of Contemporary Pediatrics ›› 2024, Vol. 26 ›› Issue (1) : 98-102. DOI: 10.7499/j.issn.1008-8830.2306093

REVIEW

Multisystem inflammatory syndrome in children in the context of coronavirus disease 2019 pandemic

ZHOU Bin, HUANG Yu-Kun, HONG Shao-Xian, JIAO Fu-Yong, XIE Kai-Sheng

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Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a complex syndrome characterized by multi-organ involvement that has emerged in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak. The clinical presentation of MIS-C is similar to Kawasaki disease but predominantly presents with fever and gastrointestinal symptoms, and severe cases can involve toxic shock and cardiac dysfunction. Epidemiological findings indicate that the majority of MIS-C patients test positive for SARS-CoV-2 antibodies. The pathogenesis and pathophysiology of MIS-C remain unclear, though immune dysregulation following SARS-CoV-2 infection is considered a major contributing factor. Current treatment approaches for MIS-C primarily involve intravenous immunoglobulin therapy and symptomatic supportive care. This review article provides a comprehensive overview of the definition, epidemiology, pathogenesis, clinical presentation, diagnosis, treatment, and prognosis of MIS-C.

Key words

Multisystem inflammatory syndrome in children / Coronavirus disease 2019 / Severe acute respiratory syndrome coronavirus 2 / Child

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ZHOU Bin, HUANG Yu-Kun, HONG Shao-Xian, JIAO Fu-Yong, XIE Kai-Sheng. Multisystem inflammatory syndrome in children in the context of coronavirus disease 2019 pandemic[J]. Chinese Journal of Contemporary Pediatrics. 2024, 26(1): 98-102 https://doi.org/10.7499/j.issn.1008-8830.2306093

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