新型冠状病毒感染流行背景下的儿童多系统炎症综合征

doi:10.7499/j.issn.1008-8830.2306093

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Abstract Multisystem inflammatory syndrome in children (MIS-C) is a complex syndrome characterized by multi-organ involvement that has emerged in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak. The clinical presentation of MIS-C is similar to Kawasaki disease but predominantly presents with fever and gastrointestinal symptoms, and severe cases can involve toxic shock and cardiac dysfunction. Epidemiological findings indicate that the majority of MIS-C patients test positive for SARS-CoV-2 antibodies. The pathogenesis and pathophysiology of MIS-C remain unclear, though immune dysregulation following SARS-CoV-2 infection is considered a major contributing factor. Current treatment approaches for MIS-C primarily involve intravenous immunoglobulin therapy and symptomatic supportive care. This review article provides a comprehensive overview of the definition, epidemiology, pathogenesis, clinical presentation, diagnosis, treatment, and prognosis of MIS-C.

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	ZHOU Bin
	HUANG Yu-Kun
	HONG Shao-Xian
	JIAO Fu-Yong
	XIE Kai-Sheng

Key words： Multisystem inflammatory syndrome in children Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Child

Received: 19 June 2023

Cite this article:

ZHOU Bin,HUANG Yu-Kun,HONG Shao-Xian et al. Multisystem inflammatory syndrome in children in the context of coronavirus disease 2019 pandemic[J]. CJCP, 2024, 26(1): 98-102.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2306093 OR http://www.zgddek.com/EN/Y2024/V26/I1/98

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