Risk factors for bronchopulmonary dysplasia in twin preterm infants: a multicenter study
FAN Yu-Wei, ZHANG Yi-Jia, WEN He-Mei, YAN Hong, SHEN Wei, DING Yue-Qin, LONG Yun-Feng, ZHANG Zhi-Gang, LI Gui-Fang, JIANG Hong, RAO Hong-Ping, QIU Jian-Wu, WEI Xian, ZHANG Ya-Yu, ZENG Ji-Bin, ZHAO Chang-Liang, XU Wei-Peng, WANG Fan, YUAN Li, YANG Xiu-Fang, LI Wei, LIN Ni-Yang, CHEN Qian, XIA Chang-Shun, ZHONG Xin-Qi, CUI Qi-Liang
Department of Pediatrics, Third Affiliated Hospital of Guangzhou Medical University/Guangdong Provincial Key Laboratory of Major Obstetric Diseases/Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology/Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangzhou 510150, China
Abstract Objective To investigate the risk factors for bronchopulmonary dysplasia (BPD) in twin preterm infants with a gestational age of <34 weeks, and to provide a basis for early identification of BPD in twin preterm infants in clinical practice. Methods A retrospective analysis was performed for the twin preterm infants with a gestational age of <34 weeks who were admitted to 22 hospitals nationwide from January 2018 to December 2020. According to their conditions, they were divided into group A (both twins had BPD), group B (only one twin had BPD), and group C (neither twin had BPD). The risk factors for BPD in twin preterm infants were analyzed. Further analysis was conducted on group B to investigate the postnatal risk factors for BPD within twins. Results A total of 904 pairs of twins with a gestational age of <34 weeks were included in this study. The multivariate logistic regression analysis showed that compared with group C, birth weight discordance of >25% between the twins was an independent risk factor for BPD in one of the twins (OR=3.370, 95%CI: 1.500-7.568, P<0.05), and high gestational age at birth was a protective factor against BPD (P<0.05). The conditional logistic regression analysis of group B showed that small-for-gestational-age (SGA) birth was an independent risk factor for BPD in individual twins (OR=5.017, 95%CI: 1.040-24.190, P<0.05). Conclusions The development of BPD in twin preterm infants is associated with gestational age, birth weight discordance between the twins, and SGA birth.
Corresponding Authors:
Cui Q-L,E-mail:cuiql_gysy@163. com
E-mail: cuiql_gysy@163.com
Cite this article:
FAN Yu-Wei,ZHANG Yi-Jia,WEN He-Mei et al. Risk factors for bronchopulmonary dysplasia in twin preterm infants: a multicenter study[J]. CJCP, 2024, 26(6): 611-618.
FAN Yu-Wei,ZHANG Yi-Jia,WEN He-Mei et al. Risk factors for bronchopulmonary dysplasia in twin preterm infants: a multicenter study[J]. CJCP, 2024, 26(6): 611-618.
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