A prospective randomized controlled study of neurofeedback combined with learning style profile intervention training in children with high-functioning autism
HUANG Ming-Xin, YU Qing, LI Yuan-Yuan
Department of Psychology, Tianjing Children's Hospital/Children's Hospital, Tianjin University, Tianjing 300134, China
Abstract Objective To explore the application of neurofeedback (NFB) combined with learning style profile (LSP) intervention training in children with high-functioning autism (HFA). Methods A prospective study was conducted to select 86 children with HFA admitted to the hospital from February 2022 to February 2024. They were divided into two groups according to the random number table method, with 43 cases in each group. In this double-blind study, the control group was given LSP intervention training, and the observation group was given NFB intervention on the basis of the treatment used in the control group. Both groups were treated for 6 months. The scores of Autism Behavior Checklist (ABC), Autism Treatment Evaluation Checklist (ATEC), Social Responsiveness Scale (SRS), and Pediatric Quality of Life (PedsQL) were compared between the two groups before intervention and at 6 months after intervention. The relationship of PedsQL score with ABC, ATEC, and SRS scores was analyzed in children with HFA. Results After 6 months of intervention, the scores of ABC, ATEC, and SRS in the observation group were significantly lower than those in the control group, while the PedsQL score in the observation group was significantly higher than that in the control group (P<0.05). The PedsQL score was negatively correlated with the ABC, ATEC, and SRS scores in children with HFA (r=-0.238, -0.381, -0.219 respectively; P<0.001). Conclusions NFB combined with LSP can effectively improve the clinical symptoms and social ability, control the development of the disease, and improve the quality of life in children with HFA.
HUANG Ming-Xin,YU Qing,LI Yuan-Yuan. A prospective randomized controlled study of neurofeedback combined with learning style profile intervention training in children with high-functioning autism[J]. CJCP, 2024, 26(10): 1066-1071.
HUANG Ming-Xin,YU Qing,LI Yuan-Yuan. A prospective randomized controlled study of neurofeedback combined with learning style profile intervention training in children with high-functioning autism[J]. CJCP, 2024, 26(10): 1066-1071.
Quinn MM, Smith T, Kalmar EL, et al. What type of learner are your students? Preferred learning styles of undergraduate gross anatomy students according to the index of learning styles questionnaire[J]. Anat Sci Educ, 2018, 11(4): 358-365. PMID: 29096042. DOI: 10.1002/ase.1748.
Matsuzaki J, Kagitani-Shimono K, Aoki S, et al. Abnormal cortical responses elicited by audiovisual movies in patients with autism spectrum disorder with atypical sensory behavior: a magnetoencephalographic study[J]. Brain Dev, 2022, 44(2): 81-94. PMID: 34563417. DOI: 10.1016/j.braindev.2021.08.007.
Moreno-García I, Cano-Crespo A, Rivera F. Results of neurofeedback in treatment of children with ADHD: a systematic review of randomized controlled trials[J]. Appl Psychophysiol Biofeedback, 2022, 47(3): 145-181. PMID: 35612676. DOI: 10.1007/s10484-022-09547-1.
Direito B, Mouga S, Sayal A, et al. Training the social brain: clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback phase IIa clinical trial in autism[J]. Autism, 2021, 25(6): 1746-1760. PMID: 33765841. DOI: 10.1177/13623613211002052.
Sun PP, Teng LS. Profiling perceptual learning styles of Chinese as a second language learners in university settings[J]. J Psycholinguist Res, 2017, 46(6): 1529-1548. PMID: 28639174. DOI: 10.1007/s10936-017-9506-y.
Haem E, Doostfatemeh M, Firouzabadi N, et al. A longitudinal item response model for aberrant behavior checklist (ABC) data from children with autism[J]. J Pharmacokinet Pharmacodyn, 2020, 47(3): 241-253. PMID: 32285302 DOI: 10.1007/s10928-020-09686-0.
Ceranoglu TA, Cassano P, Hoskova B, et al. Transcranial photobiomodulation in adults with high-functioning autism spectrum disorder: positive findings from a proof-of-concept study[J]. Photobiomodul Photomed Laser Surg, 2022, 40(1): 4-12. PMID: 34941429. DOI: 10.1089/photob.2020.4986.
Ma CH, Chen LY, Li MF, et al. Treatment of preschool children with autism spectrum disorder: a trial to evaluate a learning style profile intervention program in China[J]. Front Pediatr, 2022, 10: 831621. PMID: 35372141. PMCID: PMC8966376. DOI: 10.3389/fped.2022.831621.
Varela Barrenechea F. Efficacy of neurofeedback as a treatment for people with subjective tinnitus in reducing the symptom and related consequences: a systematic review from 2010 to 2020[J]. Acta Otorrinolaringol Esp (Engl Ed), 2023, 74(4): 253-262. PMID: 36257576. DOI: 10.1016/j.otoeng.2022.10.003.
Rosello R, Martinez-Raga J, Tomas JM, et al. Cognitive and behavioral profiles in children with autism spectrum disorder with and without attention-deficit/hyperactivity disorder[J]. Child Adolesc Ment Health, 2023, 28(2): 269-276. PMID: 35441444. DOI: 10.1111/camh.12562.
Werneck-Rohrer SG, Lindorfer TM, Waleew C, et al. Effects of an intensive slow cortical potentials neurofeedback training in female and male adolescents with autism spectrum disorder: are there sex differences?[J]. Wien Klin Wochenschr, 2022, 134(Suppl 1): 60-68. PMID: 34910250. PMCID: PMC8671879. DOI: 10.1007/s00508-021-01989-7.
Kl?bl M, Prillinger K, Diehm R, et al. Individual brain regulation as learned via neurofeedback is related to affective changes in adolescents with autism spectrum disorder[J]. Child Adolesc Psychiatry Ment Health, 2023, 17(1): 6. PMID: 36635760. PMCID: PMC9837918. DOI: 10.1186/s13034-022-00549-9.