输血依赖型地中海贫血患者生长障碍和内分泌功能的监测及干预

doi:10.7499/j.issn.1008-8830.2501080

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Abstract Transfusion-dependent thalassemia (TDT) is a severe genetic chronic hemolytic disease, and growth retardation is a common clinical feature in patients with TDT. Due to the need for regular blood transfusions, these patients often experience iron overload, which leads to various endocrine dysfunctions, including abnormalities in the growth hormone/insulin-like growth factor axis, hypothyroidism, hypoparathyroidism, hypogonadism, adrenal insufficiency, and decreased bone density. This paper reviews the clinical monitoring and intervention measures for growth disorders and related endocrine functions in patients with TDT, providing references for clinicians.

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	FAN Xin
	HUANG Yi-Yun

Key words： Thalassemia Endocrine dysfunction Growth and development Iron overload Recombinant human growth hormone

Received: 10 January 2025

Cite this article:

FAN Xin,HUANG Yi-Yun. Monitoring and interventions of growth disorders and endocrine function in children with transfusion-dependent thalassemia[J]. CJCP, 2025, 27(4): 389-394.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2501080 OR http://www.zgddek.com/EN/Y2025/V27/I4/389

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