Abstract OBJECTIVE: To investigate the biologic features of childhood acute leukemia in the northern region of China through a small cohort study in a single center. METHODS: The medical records of 688 children with acute leukemia (age ≤15 years) who were initially diagnosed at Blood Disease Hospital of Chinese Academy of Medical Sciences from October 2003 to June 2006 were retrospectively studied. RESULTS: Four hundred children were diagnosed as acute lymphoblastic leukemia (ALL), with a peak incidence at ages of 1-4 years. Two hundred and eighteen children were classified into B-cell ALL, and 34 into T-cell ALL. In the 154 patients with cytogenetic data, high hyperdiploidy was presented in 13.0% of patients, low hyperdiploidy in 3.9%, pseudodiploidy in 5.2%, and hypodiploidy in 5.8%. E2A-PBX1 fusion gene was expressed in 3.9% of children with B-cell ALL. Two hundred and twenty-two children were diagnosed as acute myeloid leukemia (AML), with a peak incidence at ages of 10-15 years. AML-M2 was the most common subtype. Acute hybrid leukemia (AHL) was confirmed in 24 children (4.2%), with a median age of 9 years. Seventy-four percent of the children with (AHL) had mainly CD13 and CD33 expression in myeloid antigen integral. CONCLUSIONS: There are differences in the biologic features of childhood acute leukemia between the northern region of China and other regions and races, which suggests that there might be differences in the pathogenesis of childhood acute leukemia in different environmental exposures.［Chin J Contemp Pediatr, 2009, 11 (10):793-796］
GUO Ye,CHEN Yu-Mei,JU Yao et al. Biologic features of 688 cases of childhood acute leukemia—a single centre retrospective study[J]. 中国当代儿科杂志, 2009, 11(10): 793-796.
GUO Ye,CHEN Yu-Mei,JU Yao et al. Biologic features of 688 cases of childhood acute leukemia—a single centre retrospective study[J]. CJCP, 2009, 11(10): 793-796.
［1］Parkin DM, Stiller CA, Draper GJ, Bieber CA. The international incidence of childhood cancer［J］. Int J Cancer, 1988, 42(4):511-520.
［2］竺晓凡.小儿血液学［M］.天津：天津科学技术出版社，2005,424-443.
［3］Gurney JG, Severson PK, Davis S, Robison LL. Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type［J］. Cancer, 1995, 75(8):2186-2195.
3.0.CO;2-F target="_blank">
［4］Blair V, Birch JM. Patterns and temporal trends in the incidence of malignant disease in children: Leukaemia and lymphoma［J］. Eur J Cancer, 1994, 30A(10):1490-1498.
［5］Hjalgrim LL, Rostgaard K, Schmiegelow K, Soderholl S, Kolmannskog S, Vettenranta K,et al.Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries［J］. J Natl Cancer Inst, 2003, 95(20):1539-1544.
［7］Ariffin H, Chen SP, Kwok CS, Quah TC, Lin HP, Yeoh AE. Ethnic differences in the frequency of subtypes of childhood acute lymphoblastic leukemia: results of the Malaysia-Singapore Leukemia Study Group［J］. J Pediatr Hematol Oncol, 2007, 29(1):27-31.
［8］Chang HH, Lu MY, Jou ST, Lin KH, Tien HF, Lin DT.Cytogenetics in childhood acute lymphoblastic leukemia in Taiwan: a single-institutional experience［J］. Pediatr Hematol Oncol, 2006, 23(6):495-506.
［9］Downing JR, Shannon KM. Acute leukemia: a pediatric perspective［J］. Cancer Cell, 2002, 2(6):437-445.
［10］Forestier E, Johansson B, Borgstrom G, Kerndrup G, Johansson J, Heim S; The NOPHO Leukemia Cytogenetic Study Group. Cytogenetic findings in a populationbased series of 787 childhood acute lymphoblastic leukemias from the Nordic countries［J］. Eur J Haematol, 2000, 64(3):194-200.
［11］Belson M, Kingsley B, Holmes A. Risk factors for acute leukemia in children: a review［J］. Environ Health Perspect, 2007, 115(1):138-145.
