Abstract Primary mediastinal choriocarcinoma is a very rare malignant tumor unrelated to pregnancy. Here a case of primary mediastinal choriocarcinoma was reported. The patient was a 13-year-old boy. He presented with shortness of breath, chest pain, fever, irritable cough and weight loss. The imaging examination showed a huge space-occupying lesion at the right edge of mediastinum. The autopsy results showed right lung and mediastinal choriocarcinoma cell carcinoma. After the introduction of the case, this paper reviewed the clinical characteristics, diagnosis and treatment of primary mediastinal choriocarcinoma.［Chin J Contemp Pediatr, 2009, 11 (7):517-520］
［1］Ueno T, Tanaka YO, Nagata M, Tsunoda H, Anno I, Ishikawa S,et al. Spectrum of germ cell tumors: from head to toe［J］. Radiographics, 2004, 24(2):387-404.
［2］Kageji T, Nagahiro S, Matsuzaki K, Kanematsu Y, Nakatani M, Okamoto Y, et al. Successful neoadjuvant synchronous chemo-and radiotherapy for disseminated primary intracranial choriocarcinoma: case report［J］. J Neurooncol, 2007, 83(2):199-204.
［3］Sullivan LG.Primary choriocarcinoma of the lung in a man［J］.Arch Pathol Lab Med, 1989, 113(1):82-83.
［4］Blokh I, Oiseth SJ, Fuks J, Jain D, Eapen S, Koulova L, et al. Metastatic choriocarcinoma in a middle-aged man presenting as a right thigh mass with venous thrombosis: a case report［J］.Med Oncol, 2003, 20(2):189-194.
［6］Takeda S, Miyoshi S, Ohta M, Minami M, Masaoka A, Matsuda H.Primary germ cell tumors in the mediastinum: a 50-year experience at a single Japanese institution［J］. Cancer, 2003, 97(2):367-376.
［7］Chen F, Tatsumi A, Numoto S. Combined choriocarcinoma and adenocarcinoma of the lung occurring in a man: case report and review of the literature［J］. Cancer, 2001, 91(1):123-129.
3.0.CO;2-3 target="_blank">
