CJCP
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1999 Vol.  1 No.  04
Published: 1999-04-15
OTHER
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Objective To review the clinical experience of cardiopulmonary bypass (CPB) in 186 infants with a body weight of less than 10 kg (8.4±0.67 kg ) during the open heart operation.Methods All patients received the congenital heart disease correction operation with cardiopulmonary bypass. The prime volume was 750～1 150 ml, HCT was 23.5±1%, and total plasma protein was 35.5±5 g/L. The average total CPB time and aortic cross clumping time were 62±5.7 min and 35.8±17 min respectively. In 30 infants, who had complex cardiac malformation, moderate hypothermia was used at a rectum temperature of 23～25℃ with a lower perfusion flow of 0.82±0.1 L/m 2(37.6±5.5 ml/kg per min) per min. Results All patients smoothly passed CPB. Twelve cases (12/186) died due to low heart output syndrome after operation. Three of them (3/12) suffered from neurologic complications.Conclusions The cardiopulmonary bypass is an adequate strategy for open heart surgery in infants with a body weight of less than 10 kg.
1999 Vol. 1 (04): 0-0 [Abstract] ( 2173 ) [HTML 1KB] [PDF 0KB] ( null )
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Objective To compare the effects of two different types of coil on patent ductus arteriosus (PDA) closure.Methods The detachable coil was used in 13 PDA cases and the gianturco coil was used in 5 cases as control. The transcatheter was performed in all the 18 cases.Results PDA was successfully closed in all cases who used the detachable coil (11 with one coil and 2 with a second coil), while success was obtained in 2 cases who used the gianturco coil. Conclusions The percutaneous transcatheter detachable coil for small PDA clousre is safer, more effective, easier to handle and less invasive.
1999 Vol. 1 (04): 0-0 [Abstract] ( 1447 ) [HTML 1KB] [PDF 0KB] ( null )
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Objective To study the effect of early education on infants intellectual development in urban communities. Methods Seventy-nine normal infants born in Fang Zhuang Community from July 1997 to Jan. 1998 were set as the early education group. Eighty-six healthy infants with conventional care who were born in the same community from Jan. 1996 to May 1997 were set as the control group. Parents were taught to carry out the early educational program beginning from the newborn period, which included motor, cognitive, speech development and social behavior. At the age of one and a half, all infants in the two groups received infant development tests of Child Development Center of China (CDCC).Results There were no significant difference in physical development, and cultural and social factors between the two groups. Intelligence tests at the age of one and a half showed that the average mental development index (MDI) and psychomotor mental development index (PDI) in the early educational group were 19.6 and 10.1 higher than those in the control group respectively. There were 31 infants (39.2%) with MDI≥130 (superexcellent) in the early educational group while there were only 5 superexcellent infants (5.8%) in the control group.Conclusions Early education for newborn infants is effective and feasible in urban communities.
1999 Vol. 1 (04): 0-0 [Abstract] ( 1432 ) [HTML 1KB] [PDF 0KB] ( null )
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Objective To study the condition of onset of child insulin-dependent diabetes mellitus (IDDM)in Guilin. Methods According to the register method of the WHO DIAMOND plan, the survey was conducted with the capture and recapture method in 1 672 257 children. Results The morbidities in children under 15 years in 1989～1998 were 0.58/100 000 (male) and 0.62/100 000 (female). The total morbidity was 0.6/100 000. Conclusions The morbidity of IDDM in children in Guilin is consistent with the multinational morbidity obtained by the WHO DIAMOND plan and is similar to that in the Orrient and other regions in China.
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Objective To measure bcl-2 and bax protein expression and explore the clinical significance in children with acute leukemia (AL). Methods Bcl-2 and bax protein were detected with a specific monoclonal antibody and flow cytometry. Results ①All 41 AL patients showed bcl-2 and bax expression with various levels.The incidence of bcl-2 and bax protein positive was 5.5%～52.4% and 4.8%～42.7% respectively. It was not correlated with AL subtypes (P>0.05). ②The high bcl-2 level (≥21%) was associated with high white blood cell (WBC) count. ③ The bcl-2 protein level of the incomplete remission and relapse group was obviously higher than that of the complete remission and previously untreated group (P<0.01). ④ The complete remission rate in the patients with bcl-2/bax protein ratio <1 was higher than that in those with a ratio ≥1 (P<0.01). Conclusions Bcl-2 protein displays an overexpression in AL and it is correlated with the prognosis and therapy reaction.
1999 Vol. 1 (04): 0-0 [Abstract] ( 1293 ) [HTML 1KB] [PDF 0KB] ( null )
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Objective To study the change of nitric oxide (NO), nitric oxide synthetase (NOS), malondialdehyde (MDA) and superoxide dismutase (SOD) level in cerebrospinal fluid (CSF) of children with viral encephalitis.Methods CSF NO, NOS, MDA and SOD were measured using colorimetric methods and the levels were compared between acute and recovery stages in children with viral encephalits.Results CSF NO ( 59.8±15.0 μmol/L),NOS (2.73±0.59 μmol/L) and SOD (28.9±12.9 NU/ml) levels in the acute stage were higher than those observed either in the recovery stage of the patients or in the normal control children (P<0.01). MDA (13.2±2.20 nmol/ml) reduced in the recovery stage but the level still was higher than normal (P<0.01). NO and MDA levels were higher in the patients with positive MRI examination than in the patients with negative MRI (P<0.01). Conclusions NO may be involved in the formation of cerebral edema and the destruction process of myelin sheath in the viral encephalitis. Thus, appropriate mannitol and antioxidative therapy for the encephalitis has to be taken into consideration.
1999 Vol. 1 (04): 0-0 [Abstract] ( 1179 ) [HTML 1KB] [PDF 0KB] ( null )
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Objective To observe the relationship between nitric oxide (NO) and glomerulus diseases.Methods The serum nitrite/nitrate (NO 2 -/NO 3 -) ratio was determined through Griess nitrate reduction in 94 children with renal disease as the patient group, including 44 cases of acute nephritis (AN) and 32 cases of nephrotic syndrome (NS) and in addition 28 healthy children as the control group. Results The serum NO 2 -/NO 3 - ratio found in the patient group (AN 70.8±34.7 μmol/L, NS 66.6±27.9 μmol/L, PN 47.4±21.4 μmol/L) were obviously higher than those seen in the control group (30.3±8 μmol/L, (P<0.01) and the ratio was higher in the acute active phase than in the remission phase of glomerulus diseases (P<0.05).Furthermore, NO 2 -/NO 3 - ratio was higher in patients with infection (93.5±32.9 μmol/L) than in the patients without infection (48.7±14 μmol/L, (P<0.01). The serum NO 2 -/NO 3 - ratio in children suffering from nephritic syndrome was negatively correlative with the concentration of the blood cholesterol (P<0.01),while it was correlative with neither plasma albumin level nor the uric protein quantity (P>0.05).Conclusions Nitric oxide seems to be involved in the pathologic process of acute nephritis, nephritic syndrome and purpuric nephritis.
1999 Vol. 1 (04): 0-0 [Abstract] ( 1237 ) [HTML 1KB] [PDF 0KB] ( null )
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Objective To investigate the change of myelin basic protein (MBP) in serum and CSF in children with central nervous system (CNS) diseases and its clinic significance, and to find a biochemistry index for CNS damage.Methods The ELISA method was used to determine the level of MBP in the serum and CSF of 85 cases of CNS diseases (58 males and 27 females, 1m～13y in age), including CNS infection, convalescence of HIE, delayed Vitmine K deficiency-induced intracranial hemorrhage, febrile convulsion and CNS tumor.Results Both means of MBP in serum and CSF were apparently higher in the CNS diseases group those of the control group. Conclusions There are different degree increase of MBP in serum and CSF in different CNS diseases, indicating a demyelinating pathological course and injurg of blood-brain barrier. The level of MBP in serum and CSF may taken as a biochemical index of reflecting CNS injury.
1999 Vol. 1 (04): 0-0 [Abstract] ( 1337 ) [HTML 1KB] [PDF 0KB] ( null )
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Objective To understand the status of chlamydia pneumoniae (CP) infection in children with or without respiratary tract infection in Nanning area. Methods The specific serum IgG, IgM antibodies against CP were detected in 149 children with acute respiratory disease and in 111 control cases (55 with non-respiratory disorders and 56 healthy children). Results The positive IgG was 26% in children with acute respiratory disease and 12% in control children (P<0.01). The total positive rate of the specific serum IgG was 20%. The positive IgG rates in groups at age <3, 3～, 6～, and 12～15 years were 16%, 15%, 24%, and 43%, respectively. Twenty-four of the 149 patients (16%) had acute CP infection. Conclusions CP infection is widely present in all age groups of children in Nanning area and the infection rate increases with age.
1999 Vol. 1 (04): 0-0 [Abstract] ( 1441 ) [HTML 1KB] [PDF 0KB] ( null )
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Objective To set up an animal model of subthreshold convulsant discharges (SCD) and to study the effects of SCD on learning and memory ability of space changes in rats.Methods Chronic electrodes were placed in the anterior frontal cortex of 18 male Wistar rats. Under continuous ECoG recording, electrial stimulation was given to the anterior frontal cortex of the rats. Changes of behaviors and ECoG of the rats were observed simultaneously. Results Epileptiform EEG discharges in the cortex and hippocampus were induced without seizure during the subconvulant electric stimulation (SES) to the anterior frontal cortex. Conclusions The anterior frontal cortex SES can cause SCD in the cortex and hippocampus.
1999 Vol. 1 (04): 0-0 [Abstract] ( 1197 ) [HTML 1KB] [PDF 0KB] ( null )
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Objective To study the effect of Lovastatin on experimental glomerular injury. Methods After nephritic syndrome model was induced with adriamycin, 16 male Wistar rats were fed with high lipid diet and divided randomly into the control group and treatment group. A dose of 4 mg/kg of Lovastatin was given daily only in the treatment group. The 24-hour urinary protein was measured every two weeks, and the serum lipid and protein were determined every four weeks. After 12 weeks, renal tissues were examined by light microscopy. Results The level of pathomorphologic score and percentage of glomerules with foam cell were 1.81±0.11 and 43.21±4.89% respectively in the control group, and 0.91±0.17 and 21.09±3.31% in the treatment group.Both pathomorphologic score and percentage of glomerules with foam cells were significantly lower in the treatment group than in the control group (P<0.01). The values of the 24-hour urinary protein excretion in the treatment group (10 weeks: 208.9±60.4 g/L; 12 weeks: 160.5±48.6 g/L) were lower than those seen in the control group (10 weeks: 276.1±57.3 g/L ; 12 weeks: 262.4±72.7 g/L) (P<0.05 and P<0.01) after ten weeks. Conclusions Lovastatin seems to significantly alleviate lipidemia, to ameliorate hyperlipidemia-induced glomerrular injury and to decrease urinary protein excretion.
1999 Vol. 1 (04): 0-0 [Abstract] ( 1162 ) [HTML 1KB] [PDF 0KB] ( null )
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Objective To determine the protective effects of Danshen complex injection against hypoxia-mediated injury in myocaridium.Methods Twenty-five mice were divided into normal control (CON) , hypoxia (HYP) , and Danshen (DAN) treatment groups. Myocardium samples were taken at two weeks after the start of experimental challenge. Myocardium succinic dehyrogenase (SDH), adenosine triphosphatase (ATP) and lactic dehydrogenase (LDH) were measured. Pathologic changes of myocardium were observed under the light and electric microscopes.Results In HYP, SDH and ATP drecrease and LDH increase were observed ; in addition, the mesenchyma of the myocardium was edematous and mitochondrions of myocardial cells were enlarged ; the arragement of filaments was irregular. However, there was no significant difference in myocardium enzyme levels and morphological structure between DAN and CON groups.Conclusions Enzymohistochemical and morphological findings in this study suggest that hypoxia causes myocardium impairment in mice and that Danshen can protect myocardium against hypoxia-induced injury.
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Objective To report and evaluate the ten-year work and effect of the Neonatal Transport Network (NTN) in Pearl River (Zhujiang) Delta in Guangdong Province. Methods The NTN means of transportation were introduced and the clinic advantages of the transportation were analyzed.Results The NTN covers 87 hospitals in this area. 8 124 newborns were transported through the NTN in the past 10 years with a mortality of 0.43% on the road. 8 089 newborns were hospitalized in the third level neonatal intensive care unit (NICU), whose mortality was 4.50%. The mortality of the whole NTN hospitals was 2.07‰.Conclusions The working mechanism of the NTN is reasonable and applicable, which improves the neonatological treatment skills of NTN participants including the third level NICU. The NTN is an important step to the reduction of the mortality of neonates.
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