CJCP
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2010 Vol.  12 No.  12
Published: 2010-12-15
CLINICAL RESEARCH
EXPERIMENTAL RESEARCH
CLINICAL EXPERIENCE
CASE REPORT
REVIEW
CLINICAL RESEARCH
933 ZHU Deng-Na, WANG Jun, JIA Yan-Jie, NIU Guo-Hui, SUN Li, XIONG Hua-Chun, ZHAI Hong-Yin, CHEN Hai, LI Lin-Chen
Clinical analysis of 322 cases of non-epileptic cerebral palsy
OBJECTIVE: To study the clinical features of non-epileptic seizures associated with cerebral palsy (CP) in children. METHODS: A total of 1 198 children with CP (age: 9 months to 6 years) were enrolled. The children with paroxysmal events were monitored by 24 hrs video-EEG (VEEG) to make sure the seizures were epileptic or non-epileptic. The symptoms, age, CP types and EEG features were observed in children with non-epileptic CP. RESULTS: Five hundred and seventy-eight children (48.24%) presented paroxysmal events. The seizures were epileptic in 231 children (19.28%) and non-epileptic in 322 cases (26.88%). In the 322 cases of non-epileptic CP, the paroxysmal events were of various kinds, including non-epileptic seizure tonic, seizure shake head, shrug shoulder or head hypsokinesis, cry or scream, panic attacks, sleep myoclonic and stereotyped movement. One hundred and fifty-eight (49.1%) out of the 322 children demonstrated nonspecific EEG abnormalities. One hundred and eleven children (34.5%) were misdiagnosed as epilepsy in primary hospitals. The CP children less than one year old showed higher frequency of non-epileptic seizures than the age groups over 1 year and 3 to 6 years. The frequency of nonepileptic seizures was the highest in children with spastic CP (168 cases, 52.2%), followed by dyskinetic CP (69 cases, 21.4%) and mixed type CP (65 cases, 20.2%). CONCLUSIONS: The paroxysmal events in children with CP partially are non-epileptic seizures and it is important to differentiate non-epileptic from epileptic seizures. The frequencies of non-epileptic seizures may be associated with a child’s age and CP type.［Chin J Contemp Pediatr, 2010, 12 (12):933-935］
2010 Vol. 12 (12): 933-935 [Abstract] ( 5348 ) [HTML 1KB] [PDF 1075KB] ( 1436 )
936 YING Yan-Fen, CHEN Shang-Qin, HU Xiao-Ya, WANG Neng-Li, LIU Hua-Lan, HU Shu-Ying, LIN Zhen-Lang
Risk factors for ventilator-associated pneumonia in neonates and the changes of isolated pathogens
OBJECTIVE: To study the risk factors for neonatal ventilator-associated pneumonia (VAP) and the changes of isolated pathogens in the last eight years. METHODS: The clinical data of 230 neonates who were admitted into the neonatal intensive care unit (NICU) and received mechanical ventilation for equal to or longer than 48 hrs in 2008 were retrospectively reviewed. The isolated pathogens were compared with those of eight years ago. RESULTS: The incidence of VAP (25.2%) in the year 2008 was lower than that of eight years ago (36.1%; P<0.05). The development of VAP was negatively correlated with the gestational age and the birth weight, but positively correlated with the duration of mechanical ventilation, intubation times, duration of hospitalization, presence of gastrointestinal bleeding and need for blood products transfusion. The main isolated pathogens were opportunistic antibiotics resistant bacteria, and the majority was gram negative bacilli (77%). The most frequently detected gram negative bacilli were Klebsiella (20%), Stenotrophomonas maltophilia (18%) and Acinetobacter (13%). Streptococcus mitis was the most frequently detected gram positive bacilli (14%). The distribution pattern of pathogens isolated in the same NICU eight years ago was somewhat different: Klebsiella (23%), Pseudomonas aeruginosa (17%), Acinetobacter (16%), Streptococcus mitis (11%), Fungi (1%) and Candida albicans (1%). CONCLUSIONS: The incidence of VAP is correlated with gestational age, birth weight, duration of mechanical ventilation and hospitalization, intubation times, presence of gastrointestinal bleeding and need for blood products transfusion. The main isolated pathogens are usually antibiotic resistant opportunistic bacteria. The detection rate of Stenotrophomonas maltophilia increased and that of Pseudomonas aeruginosa decreased when compared with eight years ago.［Chin J Contemp Pediatr, 2010, 12 (12):936-939］
2010 Vol. 12 (12): 936-939 [Abstract] ( 6376 ) [HTML 1KB] [PDF 949KB] ( 1689 )
940 HU Hong-Bo, HU Qun
ID4 methylation patterns in childhood T line and B line lymphocytic leukemia
OBJECTIVE: To study the relationship of methylation of inhibitor of DNA binding 4 (ID4) gene core promoter region with childhood T line, B line and T/B acute lymphocytic leukemia (ALL). METHODS: Methylation-specific polymerase chain reaction (MS-PCR) was used to detect the methylation status of ID4 promoter region in 18 children with newly-diagnosed ALL (2 cases of T-ALL, 13 cases of B-ALL and 3 cases of T/B-ALL). Thirty-four hospitalized children with non-tumor disease served as the control group. RESULTS: The complete methylation rate of ID4 gene promoter region (15/18, 83%) was significantly higher than the partial methylation rate (3/18, 17%) in the 18 ALL children (P<0.05). The complete methylation rate of ID4 gene promoter region in children with T-ALL, B-ALL and T/B-ALL (50%, 85% and 100% respectively) was significantly higher than that in the control group (18%; P<0.05). In contrast, the partial methylation rate and non-methylation rate in the three ALL groups were significantly lower than those in the control group (P<0.05). There were no statistically significant differences in the methylation patterns among the B-ALL, T-ALL and T/B-ALL cases. CONCLUSIONS: The methylation of ID4 promoter region may be related to the pathogenesis of childhood ALL. The methylation patterns of ID4 promoter region are identical in BALL, TALL and T/BALL.［Chin J Contemp Pediatr, 2010, 12 (12):940-942］
2010 Vol. 12 (12): 940-942 [Abstract] ( 4695 ) [HTML 1KB] [PDF 936KB] ( 1152 )
943 PENG Yan-Fen, CHENG Qian
Validity and reliability of the Chinese version of Pediatric Quality of Life Inventory Version 3.0 Asthma Module
OBJECTIVE: To evaluate the reliability and validity of parent proxyreport scales of Pediatric Quality of Life Inventory Version 3.0 (PedsQLTM) Asthma Module (Chinese version). METHODS: Two hundred and thirty-three asthmatic children and their parents from the Children's Hospital of Chongqing Medical University were enrolled. Health related quality of life was assessed using the above mentioned PedsQLTM Asthma Module. The internal consistency was assessed using Cronbach's α coefficient, while its validity was tested through correlation analysis and exploratory factor analysis. RESULTS: The internal consistency reliability for Total Scale Summary Score (Cronbach's α=0.86), Asthma Score (Cronbach's α=0.80), Treatment Score (Cronbach's α=0.78), Worry Score (Cronbach's α=0.89) and Communication Score (Cronbach's α=0.93) were excellent. Seven major factors were extracted by factor analysis which basically matched the designed structure of the original version accounting for nearly 66% of the variance. Moderate to high correlations between items and the subscales were found, and the correlation coefficients ranged from 0.41 to 0.92(P＜0.01). CONCLUSIONS: The reliability and validity of the parent proxy-report scales of PedsQLTM 3.0 Asthma Module of the Chinese version are as good as the original version.［Chin J Contemp Pediatr, 2010, 12 (12):943-946］
2010 Vol. 12 (12): 943-946 [Abstract] ( 4845 ) [HTML 1KB] [PDF 944KB] ( 1483 )
947 OU Wan-Xing, CHA Cai-Hui, WANG Ling-Hua
Mental health state of parents of children with autism
OBJECTIVE: To study the mental health state of parents of children with autism. METHODS: The mental health state was evaluated by conducting the Symptom Checklist (SCL-90) on parents of 34 children with autism and of 35 healthy children. RESULTS: The SCL-90 total scores in the fathers (162.5±34.0) and mothers of autistic children (175.1±51.0) were significantly higher than those in healthy children's parents (142.4±42.8 and 152.3±40.6, respectively) (P<0.05). The SCL-90 scores of obsessive-compulsive symptoms, depression, anxiety and paranoia in the fathers of autistic children were significantly higher than those in the fathers of healthy children (P<0.05). The SCL-90 scores of obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, paranoia, psychotic symptoms, hostility and sleep/diet were significantly higher in the mothers of autistic children than those in the mothers of healthy children (P<0.05). The mothers of autistic children presented higher SCL-90 factor scores in interpersonal sensitivity, anxiety and psychotic symptoms than the fathers (P<0.05). CONCLUSIONS: We should pay more attention to the mental health of parents of autistic children.［Chin J Contemp Pediatr, 2010, 12 (12):947-949］
2010 Vol. 12 (12): 947-949 [Abstract] ( 5584 ) [HTML 1KB] [PDF 925KB] ( 1720 )
CHILD HEALTH CARE
950 XUE Hong-Li, LI Zhi-Lan, XIE Peng-Min, LIU Hong, JIN Na, MA Guo-Yan
Survey on the influencing factors of malnutrition in rural children under 7 years of age in Gansu Province

OBJECTIVE: To study the status and influencing factors of malnutrition in rural children under 7 years of age in Gansu Province. METHODS: By stratified random cluster sampling, 9 390 rural children under 7 years of age from 4 counties of Gansu Province were enrolled. A cross-sectional investigation on children's nutritional status was performed. The major influencing factors of malnutrition were evaluated by logistic regression analysis. RESULTS: The detection rate of under-weight was 3.60% (338 cases). The growth retardation occurred in 992 cases (10.56%). Athrepsy was found in 196 cases (2.49%) out of 7 868 children under 5 years of age. Gender, age, birth weight, life style, parents' educational level and family income were influencing factors of malnutrition. CONCLUSIONS: More attention should be paid to the issue of malnutrition of rural children under 7 years of age in Gansu Province. The prevalence of malnutrition may be reduced through increasing family income and nutrition education, and improving parents' education level and children's life style.［Chin J Contemp Pediatr, 2010, 12 (12):950-953］
2010 Vol. 12 (12): 950-953 [Abstract] ( 5669 ) [HTML 1KB] [PDF 939KB] ( 1580 )
EXPERIMENTAL RESEARCH
954 LIU Feng, ZHENG Jia, LEI Min-Xiang, CHEN Hui-Ling
Expression of imprinted genes during the course of differentiation from mouse embryonic stem cells to islet-like cells in vitro

OBJECTIVE: To study the effects of in vitro inducement on the expression of SF1-G imprinted genes, Kcnq1 and Cdkn1c during the course of differentiation from mouse embryonic stem (ES) cells to islet-like cells. METHODS: Mouse ES cells were induced to differentiate into islet-like cells in vitro. The expression of islet specific markers was tested by RT-PCR or immunofluorescence. RT-PCR/RFLP was used to test the imprinted genes parental expression in cells at different stages. RESULTS: Islet specific genes, such as Insulin, Glucagon, Somatostatin, IAPP and Glut2, were expressed in differentiated cells. The proteins of insulin, C-peptide and Somastatin were expressed in the final stage cells. Imprinted gene Kcnq1 and Cdkn1c were biallelicly expressed in islet-like cells. CONCLUSIONS: Mouse ES cells can be successfully induced into islet-like cells in vitro. Gene imprinting status of Kcnq1 and Cdkn1c may be changed in differentiated cells (causing loss of imprinting) during the in vitro inducement.［Chin J Contemp Pediatr, 2010, 12 (12):954-958］
2010 Vol. 12 (12): 954-958 [Abstract] ( 5224 ) [HTML 1KB] [PDF 1417KB] ( 1541 )
959 LIN Hai-Long, CHEN Jie, HUANG Le-Ting, CHEN Yi-Ping
Efficacy of microencapsulated HepG2 cells transplantation in rats with hepatolenticular degeneration
OBJECTIVE: To evaluate the efficacy of intraperitoneal transplantation of microencapsulated HepG2 cells in rats with hepatolenticular degeneration (HLD). METHODS: HLD was induced by copper-overloaded diet with forage containing 1 g/kg copper sulfate and water with 0.185% copper sulfate for 12 weeks in rats. One hundred and twenty three-month-old male Wistar rats were randomly intraperitoneal injected with normal saline (NS), microencapsulated HepG2 cells or non-microencapsulated HepG2 cells 9 weeks after copper-overloaded diet. Blood or liver samples were obtained at five time points: 3, 7, 14, 21 and 28 days after transplantation (n=8). The other 8 rats receiving normal diet were used as the control group. Serum levels of ALT, AST, albumin and Cu and liver Cu contents were measured. RESULTS: Serum ALT, AST and Cu levels and liver Cu contents in the NS-treated HLD, microencapsulated HepG2 cells and non-microencapsulated HepG2 cells transplantation groups increased significantly at all time points, in contrast, serum albumin levels decreased significantly in the NS-treated HLD and non-microencapsulated HepG2 cells transplantation groups compared with those in the control group at all time points (P<0.05), but serum albumin levels in the microencapsulated HepG2 cells transplantation restored to the level of the control group 28 days after transplantation. Serum ALT, AST and Cu levels and liver Cu contents in the microencapsulated HepG2 cells and non-microencapsulated HepG2 cells transplantation groups were significantly lower, in contrast, albumin levels were higher than those in the NS-treated HLD group on almost time points (P<0.05). Serum levels of ALT, AST and Cu and liver Cu contents in the microencapsulated HepG2 cells transplantation group decreased 7 or 14 days after transplantation, while serum albumin levels increased significantly 14 days after transplantation compared with those in the non-microencapsulated HepG2 cells transplantation group (P<0.05). CONCLUSIONS: Intraperitoneal transplantation of microencapsulated HepG2 cells can relieve hepatic damage, reduce serum and liver Cu levels, and improve copper metabolism, therefore it is promising for the treatment of HLD.［Chin J Contemp Pediatr, 2010, 12 (12):959-962］
2010 Vol. 12 (12): 959-962 [Abstract] ( 4690 ) [HTML 1KB] [PDF 947KB] ( 1211 )
963 HEI Ming-Yan, HUANG Wei-Qing, LIU Fu-Rong
Effect of rhIGF-1 on cytochrome C and caspase-3 expression in neonatal rats with hypoxic-ischemic brain damage in vivo
OBJECTIVE: To study the effect of rhIGF-1on the mRNA and protein expression of cytochrome C (Cyt-C) and caspase-3 in neonatal rats with hypoxic-ischemic brain damage (HIBD). METHODS: Ninety neonatal Sprague-Dawley rats were randomly divided into three groups: normal control, HIBD, and HIBD+rhIGF-1 (rhIGF-1 was given intraperitoneally right after HI). Rat HIBD model was prepared according the Rice-Vannucci method. RT-PCR and Western blot methods were used to measure the mRNA and protein expression of Cyt-C and caspase-3 24, 48 and 72 hrs after HI (n=10 each time point). RESULTS: At all time points, both Cyt-C mRNA and caspase-3 mRNA expression levels in the HIBD group increased compared with those in the normal control group, and those in the HIBD+rhIGF-1 group also increased compared with that in the normal control group but decreased compared with that in the HIBD group. There were statistical significances among the three groups (P<0.01). At all time points, the changes of both Cyt-C and caspase-3 protein expression in the three groups were similar to those of the mRNA expression: both Cyt-C and caspase-3 protein expression levels increased in the HIBD group compared with those in the normal control group, and those in the HIBD+rhIGF-1 group also increased compared with those in the normal control group but decreased compared with those in the HIBD group. There were statistical significances among the three groups (P<0.01).Pearson correlation analysis showed that mRNA and protein expression of Cyt-C were positively correlated to casapse-3 mRNA and protein expression in the HIBD and the HIBD+rhIGF-1 groups. CONCLUSIONS: rhIGF-1 may inhibit the Cyt-C release and caspase-3 expression, and thus provides neuroprotection against HIBD in neonatal rats.［Chin J Contemp Pediatr, 2010, 12 (12):963-966］
2010 Vol. 12 (12): 963-966 [Abstract] ( 5326 ) [HTML 1KB] [PDF 1074KB] ( 1265 )
967 ZHAO Ya-Juan, FU Jian-Hua, SUN Mei
Effects of glutamine on platelet-derived growth factor and its receptor following septic brain damage in rats
OBJECTIVE: This study investigated the expression of platelet-derived growth factor-B (PDGF-B) and its receptor-β (PDGFR-β) in rat cerebral cortex following sepsis and explored the possible underlying mechanism of neuro-protective effect of glutamine (Gln). METHODS: One hundred and twenty 10-day-old Wistar rats were randomly divided into three groups: a control group that received an intraperitoneal injection of normal saline (1 mL/kg), a sepsis group that received an intraperitoneal injection of lipopolysaccharide (LPS, 5 mg/kg), and a Gln treatment group that was administered with Gln (1.346 g/kg) 1 hr before LPS injection. The rats were subdivided into 5 groups sacrificed at 2, 6, 12, 24 and 72 hrs after LPS or normal saline injection (n=8). The distribution and expression of PDGF-B and PDGFR-β in the cerebral cortex were ascertained by immunohistochemistry and Western blot. RESULTS: The immunohistochemistry results showed that the PDGF-B and PDGFR-β expression in the cerebral cortex increased significantly in the Gln treatment group 72 hrs after LPS injection compared with that in the control and the sepsis groups. The Western blot results showed that the PDGF-B expression in the brain tissue in the sepsis and the Gln treatment groups were significantly lower than that in the control group 2, 6, and 12 hrs after LPS injection, while the Gln treatment group had increased PDGF-B expression compared with the sepsis group 12 and 72 hrs after LPS injection. Compared with the control group, the PDGFR-β expression in the brain tissue in the sepsis group increased 2 and 6 hrs after LPS injection but decreased significantly 72 hrs after LPS injection. There were no significant differences in the PDGFR-β expression between the Gln treatment and the control groups at all different time points. CONCLUSIONS: Gln can increase the PDGF-B and PDGFR-β expression in the brain tissue of rats with sepsis. The increased PDGF-B and PDGFR-β expression might contribute to neuro-protective effects of Gln.［Chin J Contemp Pediatr, 2010, 12 (12):967-971］
2010 Vol. 12 (12): 967-971 [Abstract] ( 5043 ) [HTML 1KB] [PDF 1293KB] ( 1362 )
972 LI Yao, XIN Ying
Expression of insulin receptor substrates in pancreas of rats with intrauterine growth retardation
OBJECTIVE: To study the expression of insulin receptor substrate-1(IRS-1) and insulin receptor substrate-2 (IRS-2) in pancreas of rats with intrauterine growth retardation (IUGR). METHODS: An IUGR rat model was prepared by protein malnutrition during pregnancy. The pancreas samples of the IUGR pups were obtained at birth, and 3 weeks and 8 weeks of age. The expression of IRS-1 and IRS-2 mRNA were ascertained by RT-PCR. Western blot was used to measure the protein expression of IRS-1 and IRS-2. The rat pups born from the mother rats who received normal diet during pregnancy severed as the control group. RESULTS: The expression levels of IRS-2 mRNA and protein in pancreas of the IUGR group were significantly lower than those in the control group at all three time points (P<0.05). There were no significant differences in the expression levels of IRS-1 mRNA and protein in pancreas between the IUGR and the control groups. CONCLUSIONS: The IRS-2 expression levels in pancreas in IUGR rats decrease significantly at birth, and 3 weeks and 8 weeks of age. This might be one of the molecular mechanisms for the development of metabolic syndrome in later life in IUGR individuals.［Chin J Contemp Pediatr, 2010, 12 (12):972-975］
2010 Vol. 12 (12): 972-975 [Abstract] ( 4655 ) [HTML 1KB] [PDF 1011KB] ( 1168 )
976 YANG Ling-Yun, CHU Bo, JIANG Li-Rong
Effects of vitamin A on the immune function of intestinal mucosa lymphocytes in mice
OBJECTIVE: To study the effects of vitamin A on the development of T lymphocytes in peripheral blood and small intestine and on the cytokine response of intestinal mucosa in mice. METHODS: Twenty young mice were randomly fed with forage containing vitamin A 250 or 4 IU/g (n=10 each). Three weeks later, the levels of CD4+ CD25+ T subsets in peripheral blood and intestinal mucosa were measured by flow cytometry. The levels of cytokines IFN-γ, IL-4, IL-17 and IL-23 in stool were measured using ELISA. RESULTS: The levels of CD4+ CD25+ T subsets in peripheral blood and intestinal mucosa in the 250 IU/g vitamin A group were significantly higher than those in the 4 IU/g vitamin A group (P<0.05). The IL-4 level in stool increased, in contrast, the IL-23 level in stool decreased significantly in the 250 IU/g vitamin A group when compared with the 4 IU/g vitamin A group (P<0.05). CONCLUSIONS: vitamin A may promote the development of CD4+ CD25+ T lymphocytes in peripheral blood and small intestine. Moreover, it may be involved in intestinal mucosa-associated immune response by regulating cytokines IL-4 and IL-23.［Chin J Contemp Pediatr, 2010, 12 (12):976-978］
2010 Vol. 12 (12): 976-978 [Abstract] ( 5306 ) [HTML 1KB] [PDF 930KB] ( 1332 )
979 WANG Yu-Mei, SHENG Guang-Yao
Cell proliferation and signal pathway after knockdown and RESC concurrent rescue of RNAi lentiviral vector on human PTEN gene in T-lymphocytes
OBJECTIVE: To construct the lentiviral expression vectors of human PTEN gene for RNA interference (RNAi) and concurrent rescue of RNAi escape strategy construct (RESC) and to observe the changes of signal pathway, cell proliferation and cell cycle after PTEN gene knockdown and RESC concurrent rescue in human T-lymphocytes, in order to provide an experimental basis for a further research into the pathogenesis of acute lymphoblastic leukemia in children. METHODS: Using lentiviral vector systems to construct lentiviral vectors of human PTEN gene for RNAi and its RESC concurrent rescue, human T-lymphocytes were transfected with the lentiviruses. The cell models were established with PTEN gene knockdown (T-LC-shPTEN) and RESC concurrent rescue (T-LC-rrshPTEN). After knockdown and RESC concurrent rescue of PTEN gene, the expression of PTEN protein and the activation of AKT signal pathway, cell proliferation and cell cycle were detected by Western blot, MTT assay and flow cytometry respectively. RESULTS: The RNAi-mediated lentiviruses can down-regulate the expression of the human PTEN gene effectively. After the downregulation of PTEN gene, the T-lymphocytes grew faster. The phase G0/G1 cells decreased and the phases S and G2/M cells increased significantly. The PI3K/AKT signal pathway was activated. All RNAi phenomenon caused by PTEN gene knockdown were recovered fully by RESC concurrent rescue of RNAi. CONCLUSIONS: The lentiviral expression vectors of human PTEN gene for RNAi and RESC concurrent rescue of RNAi are constructed successfully. The PI3K/AKT signal pathway can be activated and the proliferation of human T-lymphocytes can be promoted after PTEN gene knockdown.［Chin J Contemp Pediatr, 2010, 12 (12):979-983］
2010 Vol. 12 (12): 979-983 [Abstract] ( 5507 ) [HTML 1KB] [PDF 1220KB] ( 1446 )
984 GUO Hui, MA Jiao, TONG Yu, QU Yi, MU De-Zhi, MAO Meng
A comparative study on three models of co-culture of neurons and astrocytes
OBJECTIVE: To find a better method for harvesting highly purified neurons by comparing three methods used for co-culture of neurons and astrocytes. METHODS: The co-culture models of neurons and astrocytes were established by primary culture, Banker's co-culture method or Transwell cell-culture inserts. The neurons and astrocytes cultured in vitro were from neonatal rats. RESULTS: The highly purified neurons were not harvested by primary culture because the neurons and astrocytes grew on the same cover slip and it was difficult to control the growth velocity of astrocytes. The highly purified neurons were harvested by Banker's co-culture method or the method using Transwell cell-culture inserts, but the procedure of the former was more complicated than that of the later. CONCLUSIONS: The culture method using Transwell cell-culture inserts is recommended for the establishment of the co-culture system of neurons and astrocytes.［Chin J Contemp Pediatr, 2010, 12 (12):984-987］
2010 Vol. 12 (12): 984-987 [Abstract] ( 8729 ) [HTML 1KB] [PDF 1148KB] ( 2498 )
CLINICAL EXPERIENCE
988 LU Jian-Hong, XU Mei-Yu, SHENG Yu, YANG Wei-Xia
Comparison of the efficacy of 10-day sequential therapy and conventional triple therapy for Helicobacter pylori eradication in children
No abstract available
2010 Vol. 12 (12): 988-990 [Abstract] ( 4142 ) [HTML 1KB] [PDF 928KB] ( 1381 )
991 LU Ying-Hong, WU Ya-Bin
Effect of intravenous immunoglobulin on neutrophil counts in children with Kawasaki disease
No abstract available
2010 Vol. 12 (12): 991-992 [Abstract] ( 3929 ) [HTML 1KB] [PDF 920KB] ( 1225 )
993 TANG Shuo, YOU Jie-Yu, OU Yang-Wen-Xian, ZHAO Hong-Mei, LIU Li
Treatment outcome of cyclic vomiting syndrome in children
No abstract available
2010 Vol. 12 (12): 993-994 [Abstract] ( 4649 ) [HTML 1KB] [PDF 925KB] ( 1611 )
995 ZHU Qi-Qi, LIU Ying, FENG Chen, TANG Suo-Qin
A follow up study on long-term relapse in children with neuroblastoma
No abstract available
2010 Vol. 12 (12): 995-997 [Abstract] ( 4115 ) [HTML 1KB] [PDF 931KB] ( 1209 )
998 ZHU Xiao-Hua, LIU Jian-Mei, CHEN Qiang, LI Lan, ZHANG Gao-Ping, DU Yun, HU Ci-Lang, LI Jian, WU Ai-Min
Clinical diagnosis and treatment of bronchiolitis obliterans in children
No abstract available
2010 Vol. 12 (12): 998-1000 [Abstract] ( 4570 ) [HTML 1KB] [PDF 1006KB] ( 1790 )
1001 WANG Ping, ZENG Xiao-Hui, ZHU Yi-Min, DONG Jing
Plasma hydrogen sulfide levels in children with severe pneumonia
No abstract available
2010 Vol. 12 (12): 1001-1002 [Abstract] ( 3915 ) [HTML 1KB] [PDF 920KB] ( 1021 )
1003 MAI Jing-Yun, CHEN Xian-Wei, LIN Zhen-Lang
Pleural effusion caused by peripherally inserted central catheter: report of 2 cases
No abstract available
2010 Vol. 12 (12): 1003-1004 [Abstract] ( 3694 ) [HTML 1KB] [PDF 967KB] ( 1105 )
CASE REPORT
1005 WEN Fang, SONG Yuan-Zong
A case report of Alagille syndrome
No abstract available
2010 Vol. 12 (12): 1005-1007 [Abstract] ( 5796 ) [HTML 1KB] [PDF 1014KB] ( 1618 )
REVIEW
1008 LI Ping, TONG Yu, MAO Meng
Relationship between telomere/telomerase and the developmental origins of metabolic syndrome
No abstract available
2010 Vol. 12 (12): 1008-1012 [Abstract] ( 4135 ) [HTML 1KB] [PDF 1005KB] ( 1304 )
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