先天性心脏病儿童的神经发育评估：基于贝利婴儿发展量表和韦氏智力量表的Meta分析

孙梦婷; 罗曼君; 唐嘉鹏; 陈烨; 陈可彬; 邹琪; 阮霄睿; 彭辕; 李詹雯; 文宇婷; 周成璐; 王婷婷; 秦家碧

doi:10.7499/j.issn.1008-8830.2503068

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中国当代儿科杂志 ›› 2026, Vol. 28 ›› Issue (1) : 30-41. DOI: 10.7499/j.issn.1008-8830.2503068

论著·临床研究

先天性心脏病儿童的神经发育评估：基于贝利婴儿发展量表和韦氏智力量表的Meta分析

孙梦婷 ¹ ,
罗曼君 ¹ ,
唐嘉鹏 ¹ ,
陈烨 ¹ ,
陈可彬 ¹ ,
邹琪 ¹ ,
阮霄睿 ¹ ,
彭辕 ¹ ,
李詹雯 ¹ ,
文宇婷 ¹ ,
周成璐 ¹ ,
王婷婷 ¹ ,
秦家碧 ²

作者信息 +

Neurodevelopmental assessment of children with congenital heart disease: a Meta analysis based on the Bayley Scales of Infant Development and Wechsler Intelligence Scale

Author information +

文章历史 +

摘要

目的系统评估先天性心脏病（congenital heart disease, CHD）患儿与健康对照儿童的神经发育差异。方法全面检索Web of Science、PubMed、Embase、万方数据库、中国知网、中国生物医学文献数据库和维普数据库，共筛选出从建库至2025年2月公开发表的、关于采用贝利婴儿发展量表（Bayley Scales of Infant Development, BSID）和韦氏智力量表评估CHD患儿（CHD组）与健康对照儿童（对照组）的神经发育状况的33篇文献，共计3 316例儿童。以Hedges' g作为效应量指标。采用Stata/SE 17.0软件进行Meta分析、亚组分析、敏感性分析和发表偏倚分析。结果 BSID-Ⅱ量表评估显示，与对照组相比，CHD组的智力发育指数（Hedges' g=-1.09）和精神运动发育指数（Hedges' g=-1.22）显著降低（均P<0.001）；BSID-Ⅲ量表评估显示，与对照组相比，CHD组的认知（Hedges' g=-0.78）、语言（Hedges' g=-0.65）和运动能力（Hedges' g=-0.98）得分均明显降低（均P<0.001）；韦氏智力量表评估显示，与对照组相比，CHD组的总智商（Hedges' g=-0.74）、言语智商（Hedges' g=-0.86）和操作智商（Hedges' g=-0.67）均显著低于对照组（均P<0.001）。结论 CHD患儿在认知、语言、运动功能及智力水平方面存在发育迟缓。

Abstract

Objective To systematically evaluate neurodevelopmental differences between children with congenital heart disease (CHD) and healthy controls. Methods A comprehensive search was conducted in Web of Science, PubMed, Embase, Wanfang Data, China National Knowledge Infrastructure, Chinese Biomedical Literature Service System, and VIP Database to identify studies published from database inception to February 2025 that assessed the neurodevelopment of children with CHD (CHD group) and healthy controls (control group) using the Bayley Scales of Infant Development (BSID) and the Wechsler Intelligence Scale. In total, 33 studies involving 3 316 children were included. Hedges' g was used as the effect size. Meta analysis, subgroup analysis, sensitivity analysis, and publication bias analysis were performed using STATA/SE 17.0. Results Based on BSID-II, compared with the control group, the CHD group had significantly lower mental development index (Hedges' g=-1.09) and psychomotor development index (Hedges' g=-1.22) scores (both P<0.001). Based on BSID-III, compared with the control group, the CHD group had markedly lower scores in cognition (Hedges' g=-0.78), language (Hedges' g=-0.65), and motor (Hedges' g=-0.98) (all P<0.001). The Wechsler Intelligence Scale indicated that, compared with the control group, the CHD group had significantly lower full-scale intelligence quotient (Hedges' g=-0.74), verbal intelligence quotient (Hedges' g=-0.86), and performance intelligence quotient (Hedges' g=-0.67) (all P<0.001). Conclusions Children with CHD exhibit developmental delays in cognition, language, motor function, and intelligence.

导出引用

孙梦婷, 罗曼君, 唐嘉鹏, 等. 先天性心脏病儿童的神经发育评估：基于贝利婴儿发展量表和韦氏智力量表的Meta分析[J]. 中国当代儿科杂志. 2026, 28(1): 30-41 https://doi.org/10.7499/j.issn.1008-8830.2503068

Meng-Ting SUN, Man-Jun LUO, Jia-Peng TANG, et al. Neurodevelopmental assessment of children with congenital heart disease: a Meta analysis based on the Bayley Scales of Infant Development and Wechsler Intelligence Scale[J]. Chinese Journal of Contemporary Pediatrics. 2026, 28(1): 30-41 https://doi.org/10.7499/j.issn.1008-8830.2503068

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