川崎病（Kawasaki disease, KD）是一种急性全身性免疫性血管炎，可并发冠状动脉病变，其病因机制尚不明确，可能涉及多种信号通路参与的免疫反应、炎症反应、血管内皮损伤等。近年来，环鸟苷酸-腺苷酸合成酶-干扰素基因刺激因子（cyclic GMP⁃AMP synthase⁃stimulator of interferon genes, cGAS⁃STING）信号通路因其在感染、自身免疫性疾病及炎症性疾病中的关键作用受到广泛关注。该通路通过激活Ⅰ型干扰素及促炎因子，参与炎症级联反应。该文综述cGAS⁃STING信号通路在KD中的作用机制与临床应用前景，旨在为该疾病的基础研究及临床干预提供新视角。

Kawasaki disease (KD) is an acute systemic immune‑mediated vasculitis that can lead to coronary artery lesions. Its etiology remains unclear and may involve immune responses, inflammatory reactions, and vascular endothelial injury mediated by multiple signaling pathways. In recent years, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway has attracted widespread attention for its pivotal role in infection, autoimmune diseases, and inflammatory diseases. By activating type I interferons and pro-inflammatory mediators, this pathway participates in the inflammatory cascade. This review summarizes the mechanistic roles of the cGAS-STING pathway in KD and the prospects for clinical application, providing a new perspective for basic research and clinical intervention.