目的 分析佛山地区新生儿登革热的临床特点、治疗和转归。 方法 回顾性收集2024年6—11月佛山市8家医院49例登革热新生儿病例，分析其临床特点和转归，并按确诊日龄分为早发组（≤7 d；n=32）与迟发组（7 d；n=17），比较两组的临床特点。 结果 49例患儿中，发热为主要症状（45例，92%），其次为出血倾向（12例，24%）、呼吸急促（11例，22%）和黄疸（5例，10%）；30例患儿（61%）的母亲发生围产期登革热感染。早发组新生儿母亲围产期发热、孕期确诊登革热及围产期登革热感染的比例均高于迟发组（P0.05）；早发组住院时间更长（P0.05）；迟发组谷丙转氨酶水平高于早发组（P0.05）。49例患儿给予短期止血、鼻导管给氧或无创正压通气等对症治疗后，预后良好，未出现重症或死亡病例。 结论 佛山地区新生儿登革热与母体围产期登革热暴露存在相关性。患儿以发热为主要临床表现，不同确诊日龄病例临床特征存在差异，整体预后良好。登革热流行季节应强化孕产妇围产期登革热的防护与筛查，针对高危新生儿尽早进行病原学、血生化等实验室检查。

Objective To study the clinical characteristics, treatment, and outcomes of neonatal dengue fever in Foshan. Methods A retrospective study was conducted on 49 neonatal dengue fever cases collected from eight hospitals in Foshan between June and November 2024. Clinical characteristics and outcomes were evaluated. Cases were divided into an early-onset group (diagnosed ≤7 days of age; n=32) and a late-onset group (diagnosed 7 days of age; n=17) for comparison of clinical characteristics. Results Among the 49 neonates, fever was the predominant symptom (45 cases, 92%), followed by bleeding tendency (12 cases, 24%), tachypnea (11 cases, 22%), and jaundice (5 cases, 10%). The mothers of 30 neonates (61%) had perinatal dengue infection. Rates of maternal peripartum fever, confirmed maternal dengue fever during pregnancy, and perinatal dengue infection were significantly higher in the early-onset group than in the late-onset group (P0.05). The early-onset group had a longer hospital stay than the late-onset group (P0.05). Alanine aminotransferase levels were significantly higher in the late-onset group than in the early-onset group (P0.05). Symptomatic treatments, including short-term hemostatic therapy, nasal cannula oxygen supplementation, and noninvasive positive pressure ventilation when indicated, resulted in favorable outcomes without severe cases or deaths. Conclusions Neonatal dengue fever in Foshan is associated with maternal perinatal dengue infection. Fever is the predominant clinical manifestation. Clinical characteristics differ by age at diagnosis, but overall prognosis is good. During dengue epidemic seasons, prevention and screening of perinatal dengue fever in pregnant women should be strengthened, and early laboratory tests such as pathogen detection and blood biochemistry should be performed on high-risk neonates.