患儿，男，12岁，反复腹痛5月余，肛周肿块10 d。胃肠镜检查显示回肠末端、结肠多发溃疡，结合组织病理学结果，该患儿诊断为克罗恩病。患儿合并特应性皮炎，既往已使用乌帕替尼治疗，诊断克罗恩病后，继续使用乌帕替尼治疗，共随访100周。随访期间，患儿维持临床缓解，未见严重不良反应。该病例为国内首次关于乌帕替尼治疗儿童克罗恩病的报道，对乌帕替尼治疗儿童克罗恩病具有指导意义。

A 12-year-old boy presented with recurrent abdominal pain for more than 5 months and a perianal mass for 10 days. Gastrointestinal endoscopy revealed multiple ulcers in the terminal ileum and colon, and Crohn's disease was diagnosed based on histopathology. The patient had atopic dermatitis and had previously received upadacitinib; after the diagnosis of Crohn's disease, upadacitinib was continued. During a total follow-up of 100 weeks, the patient maintained clinical remission without serious adverse reactions. This is the first report from China on upadacitinib treatment for pediatric Crohn's disease and provides guidance for its use in this population.