妊娠期肥胖母体肠道菌群对子代的影响及潜在机制研究进展

贾琼, 于彦红, 吴玉婕, 韩彤妍

中国当代儿科杂志 ›› 2026, Vol. 28 ›› Issue (5) : 624-628.

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中国当代儿科杂志 ›› 2026, Vol. 28 ›› Issue (5) : 624-628. DOI: 10.7499/j.issn.1008-8830.2509116
综述

妊娠期肥胖母体肠道菌群对子代的影响及潜在机制研究进展

作者信息 +

Research progress on the effects of maternal gut microbiota in gestational obesity on offspring and potential mechanisms

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文章历史 +

摘要

妊娠期肥胖女性的数量逐年增加,是全球面临的严峻挑战之一。母体妊娠期肥胖不仅会导致母体自身妊娠糖尿病、高血压、早产、流产等,也严重影响子代生后生长发育,增加子代肥胖和患其他代谢疾病的风险。母体妊娠期肠道菌群变化在妊娠和分娩过程中起重要作用,且肠道菌群的代谢产物也与肥胖的代谢调节密切相关。该文综述妊娠期肥胖母体肠道菌群对子代影响的潜在机制,旨在探索和深化对母体肠道菌群影响子代机制的认识,为临床干预提供研究靶点和思路。

Abstract

The number of women with gestational obesity has been increasing year by year and is a serious global challenge. Maternal obesity during pregnancy not only leads to gestational diabetes, hypertension, preterm birth, and miscarriage, but also adversely affects offspring growth and development after birth by increasing the risk of offspring obesity and other metabolic diseases. Changes in the maternal gut microbiota during pregnancy and delivery play important roles, and microbiota-derived metabolites are closely related to the metabolic regulation of obesity. This review summarizes the potential mechanisms by which the maternal gut microbiota in gestational obesity influences offspring, aiming to deepen understanding of how maternal gut microbiota affects offspring and to provide research targets and ideas for clinical intervention.

关键词

妊娠期肥胖 / 肠道菌群 / 子代肥胖 / 炎症 / 激素

Key words

Gestational obesity / Gut microbiota / Offspring obesity / Inflammation / Hormone

引用本文

导出引用
贾琼, 于彦红, 吴玉婕, . 妊娠期肥胖母体肠道菌群对子代的影响及潜在机制研究进展[J]. 中国当代儿科杂志. 2026, 28(5): 624-628 https://doi.org/10.7499/j.issn.1008-8830.2509116
Qiong JIA, Yan-Hong YU, Yu-Jie WU, et al. Research progress on the effects of maternal gut microbiota in gestational obesity on offspring and potential mechanisms[J]. Chinese Journal of Contemporary Pediatrics. 2026, 28(5): 624-628 https://doi.org/10.7499/j.issn.1008-8830.2509116

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脚注

所有作者声明无利益冲突。

基金

国家重点研发计划(2022YFA1303900)
北京市自然科学基金(7214270)
北京大学第三医院临床重点项目

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