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PDF(562 KB)
PDF(562 KB)
妊娠期肥胖母体肠道菌群对子代的影响及潜在机制研究进展
Research progress on the effects of maternal gut microbiota in gestational obesity on offspring and potential mechanisms
妊娠期肥胖女性的数量逐年增加,是全球面临的严峻挑战之一。母体妊娠期肥胖不仅会导致母体自身妊娠糖尿病、高血压、早产、流产等,也严重影响子代生后生长发育,增加子代肥胖和患其他代谢疾病的风险。母体妊娠期肠道菌群变化在妊娠和分娩过程中起重要作用,且肠道菌群的代谢产物也与肥胖的代谢调节密切相关。该文综述妊娠期肥胖母体肠道菌群对子代影响的潜在机制,旨在探索和深化对母体肠道菌群影响子代机制的认识,为临床干预提供研究靶点和思路。
The number of women with gestational obesity has been increasing year by year and is a serious global challenge. Maternal obesity during pregnancy not only leads to gestational diabetes, hypertension, preterm birth, and miscarriage, but also adversely affects offspring growth and development after birth by increasing the risk of offspring obesity and other metabolic diseases. Changes in the maternal gut microbiota during pregnancy and delivery play important roles, and microbiota-derived metabolites are closely related to the metabolic regulation of obesity. This review summarizes the potential mechanisms by which the maternal gut microbiota in gestational obesity influences offspring, aiming to deepen understanding of how maternal gut microbiota affects offspring and to provide research targets and ideas for clinical intervention.
Gestational obesity / Gut microbiota / Offspring obesity / Inflammation / Hormone
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