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以骨髓噬血为特征的汉赛巴尔通体脑膜炎1例
杜文清, 刘玲娟, 张路, 唐瑜芬, 刘利群, 李杏芳, 肖阳阳
中国当代儿科杂志 ›› 2026, Vol. 28 ›› Issue (5) : 618-623.
PDF(623 KB)
PDF(623 KB)
以骨髓噬血为特征的汉赛巴尔通体脑膜炎1例
A case of Bartonella henselae meningitis characterized by bone marrow hemophagocytosis
该文报道1例13岁男性汉赛巴尔通体脑膜炎病例。患儿以反复发热起病,无猫抓伤史,无淋巴结肿大。脑脊液检查提示白细胞数升高,经宏基因组二代测序确诊为汉赛巴尔通体感染。患儿骨髓象可见以吞噬有核红细胞为主的噬血现象,该骨髓形态学改变为全球首次报道的与汉赛巴尔通体感染相关的异常表现。患儿病程中出现一过性双髋关节疼痛,考虑为感染所致关节受累。经治疗后好转,无神经系统后遗症。该病例拓展了汉赛巴尔通体感染的临床与骨髓表现谱,提示临床上对缺乏典型淋巴结肿大的感染性发热,需警惕该病原体侵犯中枢神经系统及骨髓的可能。
A 13-year-old boy with Bartonella henselae meningitis is reported. He presented with recurrent fever with no history of cat scratches and no lymphadenopathy. Cerebrospinal fluid analysis showed an elevated white blood cell count, and Bartonella henselae infection was confirmed by metagenomic next-generation sequencing. Bone marrow examination revealed hemophagocytosis predominantly involving nucleated erythrocytes; to our knowledge, this bone marrow morphological abnormality is the first reported worldwide in association with Bartonella henselae infection. Transient bilateral hip pain occurred during the illness and was considered infection-related joint involvement. The patient improved with treatment and had no neurological sequelae. This case expands the spectrum of clinical and bone marrow manifestations of Bartonella henselae infection and warrants vigilance for possible central nervous system and bone marrow involvement in cases of fever of infectious etiology presenting without typical lymphadenopathy.
Bartonella henselae meningitis / Metagenomic next-generation sequencing / Child
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