以骨髓噬血为特征的汉赛巴尔通体脑膜炎1例

杜文清, 刘玲娟, 张路, 唐瑜芬, 刘利群, 李杏芳, 肖阳阳

中国当代儿科杂志 ›› 2026, Vol. 28 ›› Issue (5) : 618-623.

PDF(623 KB)
HTML
PDF(623 KB)
HTML
中国当代儿科杂志 ›› 2026, Vol. 28 ›› Issue (5) : 618-623. DOI: 10.7499/j.issn.1008-8830.2510033
病例报告

以骨髓噬血为特征的汉赛巴尔通体脑膜炎1例

作者信息 +

A case of Bartonella henselae meningitis characterized by bone marrow hemophagocytosis

Author information +
文章历史 +

摘要

该文报道1例13岁男性汉赛巴尔通体脑膜炎病例。患儿以反复发热起病,无猫抓伤史,无淋巴结肿大。脑脊液检查提示白细胞数升高,经宏基因组二代测序确诊为汉赛巴尔通体感染。患儿骨髓象可见以吞噬有核红细胞为主的噬血现象,该骨髓形态学改变为全球首次报道的与汉赛巴尔通体感染相关的异常表现。患儿病程中出现一过性双髋关节疼痛,考虑为感染所致关节受累。经治疗后好转,无神经系统后遗症。该病例拓展了汉赛巴尔通体感染的临床与骨髓表现谱,提示临床上对缺乏典型淋巴结肿大的感染性发热,需警惕该病原体侵犯中枢神经系统及骨髓的可能。

Abstract

A 13-year-old boy with Bartonella henselae meningitis is reported. He presented with recurrent fever with no history of cat scratches and no lymphadenopathy. Cerebrospinal fluid analysis showed an elevated white blood cell count, and Bartonella henselae infection was confirmed by metagenomic next-generation sequencing. Bone marrow examination revealed hemophagocytosis predominantly involving nucleated erythrocytes; to our knowledge, this bone marrow morphological abnormality is the first reported worldwide in association with Bartonella henselae infection. Transient bilateral hip pain occurred during the illness and was considered infection-related joint involvement. The patient improved with treatment and had no neurological sequelae. This case expands the spectrum of clinical and bone marrow manifestations of Bartonella henselae infection and warrants vigilance for possible central nervous system and bone marrow involvement in cases of fever of infectious etiology presenting without typical lymphadenopathy.

关键词

汉赛巴尔通体脑膜炎 / 宏基因组二代测序 / 儿童

Key words

Bartonella henselae meningitis / Metagenomic next-generation sequencing / Child

引用本文

导出引用
杜文清, 刘玲娟, 张路, . 以骨髓噬血为特征的汉赛巴尔通体脑膜炎1例[J]. 中国当代儿科杂志. 2026, 28(5): 618-623 https://doi.org/10.7499/j.issn.1008-8830.2510033
Wen-Qing DU, Ling-Juan LIU, Lu ZHANG, et al. A case of Bartonella henselae meningitis characterized by bone marrow hemophagocytosis[J]. Chinese Journal of Contemporary Pediatrics. 2026, 28(5): 618-623 https://doi.org/10.7499/j.issn.1008-8830.2510033

参考文献

[1]
Acar A, Çakar Özdal P, Başarır B, et al. A case series of cat-scratch disease with ocular manifestations: clinical findings and treatment approach[J]. Turk J Ophthalmol, 2023, 53(4): 226-233. PMCID: PMC10442748. DOI: 10.4274/tjo.galenos.2022.44692 .
[2]
Klotz SA, Ianas V, Elliott SP. Cat-scratch disease[J]. Am Fam Physician, 2011, 83(2): 152-155.
[3]
Hahn JS, Sum JM, Lee KP. Unusual MRI findings after status epilepticus due to cat-scratch disease[J]. Pediatr Neurol, 1994, 10(3): 255-258. DOI: 10.1016/0887-8994(94)90035-3 .
[4]
Samarkos M, Antoniadou V, Vaiopoulos AG, et al. Encephalopathy in an adult with cat-scratch disease[J]. BMJ Case Rep, 2018, 2018: bcr2017223647. PMCID: PMC5847957. DOI: 10.1136/bcr-2017-223647 .
[5]
Suzuki NN, Mitsuushi GN, Dos Santos LS, et al. Parinaud's oculoglandular syndrome: coinfection by Bartonella henselae and Sporothrix brasiliensis [J]. Acta Trop, 2024, 257: 107297. DOI: 10.1016/j.actatropica.2024.107297 .
[6]
Aslan Tuncay S, Akkoc G, Yilmaz S, et al. Unusual presentation of cat scratch disease: case report[J]. Eur J Clin Microbiol Infect Dis, 2024, 43(8): 1661-1665. PMCID: PMC11271358. DOI: 10.1007/s10096-024-04872-1 .
[7]
Kelly PJ. A review of bacterial pathogens in Ctenocephalides felis in New Zealand[J]. N Z Vet J, 2004, 52(6): 352-357. DOI: 10.1080/00480169.2004.36451 .
[8]
Gerber JE, Johnson JE, Scott MA, et al. Fatal meningitis and encephalitis due to Bartonella henselae bacteria[J]. J Forensic Sci, 2002, 47(3): 640-644.
[9]
Fouch B, Coventry S. A case of fatal disseminated Bartonella henselae infection (cat-scratch disease) with encephalitis[J]. Arch Pathol Lab Med, 2007, 131(10): 1591-1594. DOI: 10.5858/2007-131-1591-ACOFDB .
[10]
James L, Keshwani N, Haffner D, et al. Scratching past lymphadenopathy: a case of Bartonella henselae encephalitis[J]. Pediatr Ann, 2020, 49(8): e359-e362. DOI: 10.3928/19382359-20200713-01 .
[11]
Cerpa Polar R, Orellana G, Silva Caso W, et al. Encephalitis with convulsive status in an immunocompetent pediatric patient caused by Bartonella henselae [J]. Asian Pac J Trop Med, 2016, 9(6): 610-613. DOI: 10.1016/j.apjtm.2016.03.030 .
[12]
Kusumanto YH, Veenhoven RH, Bokma JA, et al. 2 patients with atypical manifestations of cat-scratch disease[J]. Ned Tijdschr Geneeskd, 1997, 141(8): 385-387.
[13]
Rondet B, Sarret C, Lacombe P, et al. Neurological symptoms with Bartonella henselae infection: report on 2 pediatric cases[J]. Arch Pediatr, 2012, 19(8): 823-826. DOI: 10.1016/j.arcped.2012.05.011 .
[14]
Cherinet Y, Tomlinson R. Cat scratch disease presenting as acute encephalopathy[J]. Emerg Med J, 2008, 25(10): 703-704. DOI: 10.1136/emj.2008.060616 .
[15]
Genizi J, Kasis I, Schif A, et al. Effect of high-dose methyl-prednisolone on brainstem encephalopathy and basal ganglia impairment complicating cat scratch disease[J]. Brain Dev, 2007, 29(6): 377-379. DOI: 10.1016/j.braindev.2006.11.001 .
[16]
Brenneis C, Scherfler C, Engelhardt K, et al. Encephalitis lethargica following Bartonella henselae infection[J]. J Neurol, 2007, 254(4): 546-547. DOI: 10.1007/s00415-006-0319-4 .
[17]
Nakamura M, Ura S, Yabe I, et al. Cat scratch disease-associated encephalitis followed by parkinsonism[J]. Intern Med, 2022, 61(20): 3115-3120. PMCID: PMC9646356. DOI: 10.2169/internalmedicine.9047-21 .
[18]
Fan J, Ali H. Cat scratch disease causing encephalitis[J]. Proc (Bayl Univ Med Cent), 2020, 33(3): 440-441. PMCID: PMC7340468. DOI: 10.1080/08998280.2020.1756141 .
[19]
Marienfeld CB, Dicapua DB, Sze GK, et al. Expressive aphasia as a presentation of encephalitis with Bartonella henselae infection in an immunocompetent adult[J]. Yale J Biol Med, 2010, 83(2): 67-71. PMCID: PMC2892771.
[20]
Nhan J, Deshpande S, Futterman C, et al. Bartonella henselae infection-mediated shunt nephritis[J]. Clin Nephrol Case Stud, 2024, 12: 1-5. PMCID: PMC10783168. DOI: 10.5414/CNCS111233 .

脚注

所有作者均声明无利益冲突。


版权

版权所有 © 2023中国当代儿科杂志
PDF(623 KB)
HTML

Accesses

Citation

Detail

段落导航
相关文章

/