新生儿缺氧缺血性脑病亚低温治疗临床管理专家共识(2026年)

中国医师协会新生儿科医师分会循证专业委员会

中国当代儿科杂志 ›› 2026, Vol. 28 ›› Issue (7) : 779-790.

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中国当代儿科杂志 ›› 2026, Vol. 28 ›› Issue (7) : 779-790. DOI: 10.7499/j.issn.1008-8830.2603030
标准·方案·指南

新生儿缺氧缺血性脑病亚低温治疗临床管理专家共识(2026年)

作者信息 +

Expert consensus on the clinical management of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (2026)

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文章历史 +

摘要

新生儿缺氧缺血性脑病(hypoxic‑ischemic encephalopathy, HIE)是导致新生儿死亡及远期神经发育障碍的重要疾病。亚低温治疗作为改善中、重度HIE新生儿预后的有效措施,其规范管理对改善患儿预后至关重要。中国医师协会新生儿科医师分会循证专业委员会基于国内外相关证据,采用证据推荐分级的评估、制订与评价方法,结合专家意见,围绕亚低温治疗临床管理的执行层面,制定了《新生儿缺氧缺血性脑病亚低温治疗临床管理专家共识(2026年)》。该共识聚焦医护人员关注的亚低温治疗临床实践中的14个关键问题,形成了22条推荐意见,旨在为HIE患儿亚低温的临床管理提供规范、可操作的实践参考与流程指引,促进医护一体化协作,改善患儿预后。

Abstract

Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal death and long-term neurodevelopmental impairment. Therapeutic hypothermia is an effective intervention to improve the prognosis of neonates with moderate to severe HIE, and its standardized management is crucial for optimizing outcomes. Based on domestic and international evidence and expert opinion, the Evidence-Based Medicine Group, Neonatologist Society, Chinese Medical Doctor Association developed the "Expert consensus on the clinical management of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (2026)" using the Grading of Recommendations Assessment, Development, and Evaluation approach. The consensus focuses on 14 key clinical questions related to therapeutic hypothermia that are of concern to medical staff and formulates 22 recommendations. It aims to provide standardized and practical guidance and workflow for the clinical management of therapeutic hypothermia in neonates with HIE, promote integrated collaboration between physicians and nurses, and improve patient outcomes.

关键词

缺氧缺血性脑病 / 亚低温治疗 / 专家共识 / 新生儿

Key words

Hypoxic-ischemic encephalopathy / Therapeutic hypothermia / Expert consensus / Neonate

引用本文

导出引用
中国医师协会新生儿科医师分会循证专业委员会. 新生儿缺氧缺血性脑病亚低温治疗临床管理专家共识(2026年)[J]. 中国当代儿科杂志. 2026, 28(7): 779-790 https://doi.org/10.7499/j.issn.1008-8830.2603030
Evidence-Based Medicine Group, Neonatologist Society, Chinese Medical Doctor Association. Expert consensus on the clinical management of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (2026)[J]. Chinese Journal of Contemporary Pediatrics. 2026, 28(7): 779-790 https://doi.org/10.7499/j.issn.1008-8830.2603030

参考文献

[1]
Huntingford SL, Boyd SM, Mcintyre SJ, et al. Long-term outcomes following hypoxic ischemic encephalopathy[J]. Clin Perinatol, 2024, 51(3): 683-709. DOI: 10.1016/j.clp.2024.04.008 .
[2]
Pappas A, Milano G, Chalak LF. Hypoxic-ischemic encephalopathy: changing outcomes across the spectrum[J]. Clin Perinatol, 2023, 50(1): 31-52. DOI: 10.1016/j.clp.2022.11.007 .
[3]
Bonifacio SL, Liu J, Lee HC, et al. Trends in HIE and use of hypothermia in California: opportunities for improvement[J]. Pediatrics, 2024, 154(3): e2023063032. DOI: 10.1542/peds.2023-063032 .
[4]
Jacobs SE, Berg M, Hunt R, et al. Cooling for newborns with hypoxic ischaemic encephalopathy[J]. Cochrane Database Syst Rev, 2013, 2013(1): CD003311. PMCID: PMC7003568. DOI: 10.1002/14651858.CD003311.pub3 .
[5]
Brouwers MC, Kho ME, Browman GP, et al. AGREE II: advancing guideline development, reporting and evaluation in health care[J]. CMAJ, 2010, 182(18): E839-E842. PMCID: PMC3001530. DOI: 10.1503/cmaj.090449 .
[6]
Aromataris E, Lockwood C, Porritt K, et al. JBI Manual for Evidence Synthesis[M/OL]. [2025-09-27].
[7]
Shea BJ, Reeves BC, Wells G, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both[J]. BMJ, 2017, 358: j4008. PMCID: PMC5833365. DOI: 10.1136/bmj.j4008 .
[8]
Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials[J]. BMJ, 2019, 366: l4898. DOI: 10.1136/bmj.l4898 .
[9]
Wells GA, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses[EB/OL]. [2025-09-27].
[10]
Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations[J]. BMJ, 2008, 336(7650): 924-926. PMCID: PMC2335261. DOI: 10.1136/bmj.39489.470347.AD .
[11]
Brozek JL, Akl EA, Alonso-Coello P, et al. Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions[J]. Allergy, 2009, 64(5): 669-677. DOI: 10.1111/j.1398-9995.2009.01973.x .
[12]
Diamond IR, Grant RC, Feldman BM, et al. Defining consensus: a systematic review recommends methodologic criteria for reporting of Delphi studies[J]. J Clin Epidemiol, 2014, 67(4): 401-409. DOI: 10.1016/j.jclinepi.2013.12.002 .
[13]
Tomimatsu T, Fukuda H, Kanagawa T, et al. Effects of hyperthermia on hypoxic-ischemic brain damage in the immature rat: its influence on caspase-3-like protease[J]. Am J Obstet Gynecol, 2003, 188(3): 768-773. DOI: 10.1067/mob.2003.163 .
[14]
Queensland Clinical Guidelines. Hypoxic ischaemic encephalopathy (HIE)[EB/OL]. [2025-06-06].
[15]
邵肖梅, 叶鸿瑁, 丘小汕. 实用新生儿学[M]. 5版. 北京: 人民卫生出版社, 2019.
[16]
中华医学会儿科学分会新生儿学组, 中华儿科杂志编辑委员会. 亚低温治疗新生儿缺氧缺血性脑病专家共识(2022)[J]. 中华儿科杂志, 2022, 60(10): 983-989. DOI: 10.3760/cma.j.cn112140-20220418-00344 .
[17]
Lemyre B, Chau V. Hypothermia for newborns with hypoxic-ischemic encephalopathy[J]. Paediatr Child Health, 2018, 23(4): 285-291. PMCID: PMC6007306. DOI: 10.1093/pch/pxy028 .
[18]
Garnaud H, Cressens S, Arbaoui H, et al. Servo-controlled therapeutic hypothermia during neonatal transport: a before-and-after quality improvement project[J]. Eur J Pediatr, 2024, 183(10): 4259-4264. DOI: 10.1007/s00431-024-05691-4 .
[19]
Leon RL, Krause KE, Sides RS, et al. Therapeutic hypothermia in transport permits earlier treatment regardless of transfer distance[J]. Am J Perinatol, 2022, 39(6): 633-639. DOI: 10.1055/s-0040-1718372 .
[20]
Torre Monmany N, Behrsin J, Leslie A. Servo-controlled cooling during neonatal transport for babies with hypoxic-ischaemic encephalopathy is practical and beneficial: experience from a large UK neonatal transport service[J]. J Paediatr Child Health, 2019, 55(5): 518-522. DOI: 10.1111/jpc.14232 .
[21]
Lumba R, Mally P, Espiritu M, et al. Therapeutic hypothermia during neonatal transport at Regional Perinatal Centers: active vs. passive cooling[J]. J Perinat Med, 2019, 47(3): 365-369. DOI: 10.1515/jpm-2018-0302 .
[22]
Szakmar E, Kovacs K, Meder U, et al. Feasibility and safety of controlled active hypothermia treatment during transport in neonates with hypoxic-ischemic encephalopathy[J]. Pediatr Crit Care Med, 2017, 18(12): 1159-1165. DOI: 10.1097/PCC.0000000000001339 .
[23]
Stafford TD, Hagan JL, Sitler CG, et al. Therapeutic hypothermia during neonatal transport: active cooling helps reach the target[J]. Ther Hypothermia Temp Manag, 2017, 7(2): 88-94. DOI: 10.1089/ther.2016.0022 .
[24]
Goel N, Mohinuddin SM, Ratnavel N, et al. Comparison of passive and servo-controlled active cooling for infants with hypoxic-ischemic encephalopathy during neonatal transfers[J]. Am J Perinatol, 2017, 34(1): 19-25. DOI: 10.1055/s-0036-1584151 .
[25]
Mcnellis E, Fisher T, Kilbride HW. Safety and effectiveness of whole body cooling therapy for neonatal encephalopathy on transport[J]. Air Med J, 2015, 34(4): 199-206. DOI: 10.1016/j.amj.2015.03.002 .
[26]
Torre Monmany N, Maya Gallego S, Esclapés Giménez T, et al. Challenges in the application of non-servocontrolled therapeutic hypothermia during neonatal transport in Catalonia[J]. An Pediatr (Engl Ed), 2021, 95(6): 459-466. DOI: 10.1016/j.anpede.2021.07.005 .
[27]
Umbaldo A, Capasso L, Spena GR, et al. Passive therapeutic hypothermia during transfer of hypoxic-ischemic newborn: evidences and feasibility from a neonatal emergency transport service[J]. Ital J Gynaecol Obstet, 2019, 31(4): 35-40. DOI: 10.14660/2385-0868-135 .
[28]
Leben M, Nolimal M, Vidmar I, et al. Passive therapeutic hypothermia during ambulance and helicopter secondary neonatal transport in neonates with hypoxic brain injury: a 10-year retrospective survey[J]. Childs Nerv Syst, 2018, 34(12): 2463-2469. DOI: 10.1007/s00381-018-3914-7 .
[29]
Tran HTT, Tran DM, Le HT, et al. Cooling during transportation of newborns with hypoxic ischemic encephalopathy using phase change material mattresses in low-resource settings: a randomized controlled trial in Hanoi, Vietnam[J]. BMC Pediatr, 2024, 24(1): 509. PMCID: PMC11308214. DOI: 10.1186/s12887-024-04987-6 .
[30]
Awal MA, Lai MM, Azemi G, et al. EEG background features that predict outcome in term neonates with hypoxic ischaemic encephalopathy: a structured review[J]. Clin Neurophysiol, 2016, 127(1): 285-296. DOI: 10.1016/j.clinph.2015.05.018 .
[31]
卫生部新生儿疾病重点实验室, 复旦大学附属儿科医院. 亚低温治疗新生儿缺氧缺血性脑病方案(2011)[J]. 中国循证儿科杂志, 2011, 6(5): 337-339. DOI: 10.3969/j.issn.1673-5501.2011.05.005 .
[32]
Lee IC, Hong SY, Weng YH, et al. Amplitude integrated electroencephalography and continuous electroencephalography monitoring is crucial in high-risk infants and their findings correlate with neurodevelopmental outcomes[J]. Front Pediatr, 2021, 9: 691764. PMCID: PMC8369262. DOI: 10.3389/fped.2021.691764 .
[33]
Jan S, Northington FJ, Parkinson CM, et al. EEG monitoring technique influences the management of hypoxic-ischemic seizures in neonates undergoing therapeutic hypothermia[J]. Dev Neurosci, 2017, 39(1-4): 82-88. PMCID: PMC5607012. DOI: 10.1159/000454855 .
[34]
Bashir RA, Espinoza L, Vayalthrikkovil S, et al. Implementation of a neurocritical care program: improved seizure detection and decreased antiseizure medication at discharge in neonates with hypoxic-ischemic encephalopathy[J]. Pediatr Neurol, 2016, 64: 38-43. DOI: 10.1016/j.pediatrneurol.2016.07.007 .
[35]
Elshorbagy HH, Azab AA, Kamal NM, et al. Value of electroencephalographic monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia[J]. J Pediatr Neurosci, 2016, 11(4): 309-315. PMCID: PMC5314843. DOI: 10.4103/1817-1745.199467 .
[36]
Lemyre B, Ly L, Chau V, et al. Initiation of passive cooling at referring centre is most predictive of achieving early therapeutic hypothermia in asphyxiated newborns[J]. Paediatr Child Health, 2017, 22(5): 264-268. PMCID: PMC5804879. DOI: 10.1093/pch/pxx062 .
[37]
Takenouchi T, Iwata O, Nabetani M, et al. Therapeutic hypothermia for neonatal encephalopathy: JSPNM MHLW Japan Working Group Practice Guidelines Consensus Statement from the Working Group on Therapeutic Hypothermia for Neonatal Encephalopathy, Ministry of Health, Labor and Welfare (MHLW), Japan, and Japan Society for Perinatal and Neonatal Medicine (JSPNM)[J]. Brain Dev, 2012, 34(2): 165-170. DOI: 10.1016/j.braindev.2011.06.009 .
[38]
Mclean L, Dalrymple H, Sasidharan L, et al. Efficacy of therapeutic hypothermia during transport of newborns with perinatal hypoxic-ischaemic encephalopathy: experience from newborn and paediatric transport service, New South Wales[J]. J Paediatr Child Health, 2025, 61(3): 411-416. DOI: 10.1111/jpc.16758 .
[39]
Buchiboyina A, Ma E, Yip A, et al. Servo controlled versus manual cooling methods in neonates with hypoxic ischemic encephalopathy[J]. Early Hum Dev, 2017, 112: 35-41. DOI: 10.1016/j.earlhumdev.2017.06.011 .
[40]
Lee CYZ, Chakranon P, Lee SWH. Comparative efficacy and safety of neuroprotective therapies for neonates with hypoxic ischemic encephalopathy: a network meta-analysis[J]. Front Pharmacol, 2019, 10: 1221. PMCID: PMC6824259. DOI: 10.3389/fphar.2019.01221 .
[41]
Hine K, Hosono S, Kawabata K, et al. Nasopharynx is well-suited for core temperature measurement during hypothermia therapy[J]. Pediatr Int, 2017, 59(1): 29-33. DOI: 10.1111/ped.13046 .
[42]
Wu TW, Schmicker R, Wood TR, et al. Esophageal versus rectal temperature monitoring during whole-body therapeutic hypothermia for hypoxic-ischemic encephalopathy: association with short- and long-term outcomes[J]. J Pediatr, 2024, 268: 113933. PMCID: PMC11045319. DOI: 10.1016/j.jpeds.2024.113933 .
[43]
Liu JF, Wu HW, Li ZG, et al. aEEG monitoring analysis of lesion degree and long-term prognosis in newborns with HIE[J]. Eur Rev Med Pharmacol Sci, 2016, 20(13): 2863-2867.
[44]
林雨焮, 冯骁, 张艺丹, 等. 新生儿缺氧缺血性脑病不同复温时间亚低温治疗临床效果的前瞻性随机对照研究[J]. 中国当代儿科杂志, 2023, 25(4): 350-356. PMCID: PMC10120331. DOI: 10.7499/j.issn.1008-8830.2211158 .
[45]
Makker P, Kanei Y, Misra D. Clinical effect of rebound hyperthermia after cooling postcardiac arrest: a meta-analysis[J]. Ther Hypothermia Temp Manag, 2017, 7(4): 206-209. DOI: 10.1089/ther.2017.0009 .
[46]
Battin MR, Davis SL, Gardner M, et al. Seizures after initiation of rewarming in cooled infants with hypoxic ischaemic encephalopathy[J]. Pediatr Res, 2024, 95(3): 752-757. DOI: 10.1038/s41390-023-02863-0 .
[47]
Alsaleem M, Saadeh L, Elberson V, et al. Subcutaneous fat necrosis, a rare but serious side effect of hypoxic-ischemic encephalopathy and whole-body hypothermia[J]. J Perinat Med, 2019, 47(9): 986-990. DOI: 10.1515/jpm-2019-0172 .
[48]
Alsofyani KA. Neonatal subcutaneous fat necrosis with hypercalcemia treatment using calcitonin[J]. Saudi Med J, 2018, 39(6): 622-626. PMCID: PMC6146218. DOI: 10.15537/smj.2018.6.22025 .
[49]
Chen KL, Chen CY, Chiu HC. Extensive subcutaneous fat necrosis after selective head cooling in a newborn with hypoxic ischemic encephalopathy[J]. Dermatologica Sinica, 2016, 34(4): 211-212. DOI: 10.1016/j.dsi.2016.01.005 .
[50]
De Rose DU, Maddaloni C, Salvatori G, et al. Case report: hypercalcemia, subcutaneous fat necrosis and nephrocalcinosis in neonates who undergo therapeutic hypothermia: a not so rare association, with different onset time[J]. Front Pediatr, 2024, 12: 1477378. PMCID: PMC11774902. DOI: 10.3389/fped.2024.1477378 .
[51]
Elsayed EOS, Yusuf K, Fraulin FOG, et al. Haematoma complicating subcutaneous fat necrosis of the newborn: a rare complication following therapeutic hypothermia[J]. BMJ Case Rep, 2020, 13(6): e234360. PMCID: PMC7295416. DOI: 10.1136/bcr-2020-234360 .
[52]
Grass B, Weibel L, Hagmann C, et al. Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register[J]. BMC Pediatr, 2015, 15: 73. PMCID: PMC4496817. DOI: 10.1186/s12887-015-0395-7 .
[53]
Guillermo M, Khokhar A, Fofah O, et al. The use of pamidronate for the treatment of severe hypercalcemia secondary to subcutaneous fat necrosis in two newborn infants[J]. Horm Res Paediatr, 2022, 95: 95-96. DOI: 10.1159/000525242 .
[54]
Heskin L, Khan MAA, Ho PH, et al. Subcutaneous fat necrosis requiring plastic surgical intervention in an infant treated with whole-body cooling[J]. JPRAS Open, 2018, 15: 61-65. PMCID: PMC7061566. DOI: 10.1016/j.jpra.2017.10.006 .
[55]
Martínez de Zabarte Fernández JM, Laliena Aznar S, Corella Aznar E, et al. Subcutaneous fat necrosis and persistent hypercalcaemia in a newborn treated with therapeutic neonatal hypothermia. A case report[J]. Arch Argent Pediatr, 2016, 114(1): e13-e16. DOI: 10.5546/aap.2016.e13 .
[56]
Mehta S, Gupta NP, Batra A, et al. Subcutaneous fat necrosis in an infant with hypoxic ischaemic encephalopathy stage 3: an uncommon association[J]. BMJ Case Rep, 2021, 14(7): e237933. PMCID: PMC8319971. DOI: 10.1136/bcr-2020-237933 .
[57]
Rodd C, Schwieger-Briel A, Hagmann C. Subcutaneous fat necrosis associated with hypercalcemia in neonates with neonatal encephalopathy treated with therapeutic hypothermia[J]. Semin Fetal Neonatal Med, 2021, 26(4): 101269. DOI: 10.1016/j.siny.2021.101269 .
[58]
Szpecht D, Bagnosz-Magnuszewska A, Szymankiewicz M, et al. Subcutaneous fat necrosis in neonates after therapeutic hypothermia: report of 2 cases[J]. J Perinat Med, 2015, 43: 876. DOI: 10.1515/jpm-2015-2003 .
[59]
Luton A, Hernandez J, Patterson CR, et al. Preventing pressure injuries in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy: an interprofessional quality improvement project[J]. Adv Neonatal Care, 2017, 17(4): 237-244. DOI: 10.1097/ANC.0000000000000383 .
[60]
El-Dib M, Szakmar E, Chakkarapani E, et al. Challenges in respiratory management during therapeutic hypothermia for neonatal encephalopathy[J]. Semin Fetal Neonatal Med, 2021, 26(4): 101263. DOI: 10.1016/j.siny.2021.101263 .
[61]
黄益, 赵静, 滑心恬, 等. 新生儿经鼻高流量氧疗应用指南(2023)[J]. 中国循证医学杂志, 2024, 24(4): 385-404.
[62]
Kumar J, Anne RP, Meena J, et al. To feed or not to feed during therapeutic hypothermia in asphyxiated neonates: a systematic review and meta-analysis[J]. Eur J Pediatr, 2023, 182(6): 2759-2773. DOI: 10.1007/s00431-023-04950-0 .
[63]
Hu Y, Chen F, Xiang X, et al. Early versus delayed enteral nutrition for neonatal hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia: a randomized controlled trial[J]. Ital J Pediatr, 2022, 48(1): 146. PMCID: PMC9380332. DOI: 10.1186/s13052-022-01342-2 .
[64]
Arman D, Cömert S, Kara N, et al. The effects of nutrition on mesenteric oxygenation among neonates with neonatal encephalopathy: a randomized clinical trial[J]. Pediatr Res, 2025, 97(7): 2390-2397. DOI: 10.1038/s41390-024-03648-9 .
[65]
Chang LL, Wynn JL, Pacella MJ, et al. Enteral feeding as an adjunct to hypothermia in neonates with hypoxic-ischemic encephalopathy[J]. Neonatology, 2018, 113(4): 347-352. DOI: 10.1159/000487848 .
[66]
Kulkarni T, Charki S, Biradar V, et al. Feasibility of minimal enteral nutrition in neonates with perinatal asphyxia during therapeutic hypothermia: a randomized controlled trial[J]. Curr Pediatr Res, 2021, 25(3): 466-471.
[67]
Gale C, Longford NT, Jeyakumaran D, et al. Feeding during neonatal therapeutic hypothermia, assessed using routinely collected National Neonatal Research Database data: a retrospective, UK population-based cohort study[J]. Lancet Child Adolesc Health, 2021, 5(6): 408-416. PMCID: PMC8131202. DOI: 10.1016/S2352-4642(21)00026-2 .
[68]
Alburaki W, Scringer-Wilkes M, Dawoud F, et al. Feeding during therapeutic hypothermia is safe and may improve outcomes in newborns with perinatal asphyxia[J]. J Matern Fetal Neonatal Med, 2022, 35(25): 9440-9444. DOI: 10.1080/14767058.2022.2041594 .
[69]
Thyagarajan B, Tillqvist E, Baral V, et al. Minimal enteral nutrition during neonatal hypothermia treatment for perinatal hypoxic-ischaemic encephalopathy is safe and feasible[J]. Acta Paediatr, 2015, 104(2): 146-151. DOI: 10.1111/apa.12838 .
[70]
何晓光, 李建波, 杜邦, 等. 新生儿亚低温治疗期间肠道超声指导早期肠内喂养的临床研究[J]. 中华新生儿科杂志(中英文), 2023, 38(3): 136-140. DOI: 10.3760/cma.j.issn.2096-2932.2023.03.002 .
[71]
钟琴, 包蕾, 李禄全. 新生儿缺氧缺血性脑病亚低温治疗期间开展肠内营养的回顾性非随机对照研究[J]. 中国循证儿科杂志, 2021, 16(3): 209-213. DOI: 10.3969/j.issn.1673-5501.2021.03.007 .
[72]
中国医师协会新生儿科医师分会循证专业委员会, 中华儿科杂志编辑委员会. 早产儿经口喂养临床实践专家共识(2025)[J]. 中华儿科杂志, 2025, 63(1): 27-38. DOI: 10.3760/cma.j.cn112140-20240911-00632 .
[73]
中国医师协会儿科医师分会儿童保健学组. NICU出院高危儿0~3岁生长发育随访管理技术的专家共识[J]. 中国儿童保健杂志, 2021, 29(8): 809-814. DOI: 10.11852/zgetbjzz2020-2035 .

脚注

本共识制订获得相关基金项目资助,资助方仅提供经费支持,不参与且不干预本共识的学术设计、证据评价、推荐意见形成及稿件撰写过程。在本共识制订全过程中,参与的所有成员均无相关的经济、专业或个人利益冲突,未接受任何旨在影响推荐意见中立性的商业资助。

基金

国家重点研发计划(2024YFC2707700)
四川省自然科学基金项目(2025ZNSFSC0693)
国家自然科学基金重点项目(82530056)

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