生长板功能调控与身材矮小症的相关研究及治疗进展

莫国生; 马云婷; 桂宝恒

doi:10.7499/j.issn.1008-8830.2605062

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中国当代儿科杂志 ›› 2026, Vol. 28 ›› Issue (9) : 1150-1156. DOI: 10.7499/j.issn.1008-8830.2605062

综述

生长板功能调控与身材矮小症的相关研究及治疗进展

莫国生 ¹ ,
马云婷 ¹ (综述) ,
桂宝恒 ¹^,²^,³

作者信息 +

Growth plate regulation and short stature: mechanistic insights and therapeutic advances

Guo-Sheng MO ¹ ,
Yun-Ting MA ¹ ,
Bao-Heng GUI ¹^,²^,³

Author information +

文章历史 +

摘要

生长板是长骨纵向生长的关键结构，其功能受全身内分泌、局部旁分泌、细胞外基质结构支持及细胞内信号通路等复杂网络协同调控，生长板调控紊乱可导致身材矮小症（short stature, SS）。目前SS的治疗以各种激素替代方案为主，但疗效存在差异。靶向药物、分子靶向递送及基因治疗等新兴疗法已展现出应用潜力。该文将阐述生长板的结构与功能，归纳其功能紊乱与SS的关联，总结相关研究与治疗进展，为解析SS的分子致病机制、探索精准治疗策略提供参考。

Abstract

The growth plate is the key structure for longitudinal growth of long bones, and its function is coordinated by a complex network of systemic endocrine signals, local paracrine signals, structural support from the extracellular matrix, and intracellular signaling pathways. Dysregulation of this network can lead to short stature (SS). At present, treatment of SS mainly relies on various hormone replacement therapies, but efficacy varies. Emerging approaches, including targeted drugs, molecularly targeted delivery, and gene therapy, have demonstrated potential for clinical application. This review describes the structure and function of the growth plate, summarizes the association between its dysfunction and SS, and outlines related research and therapeutic advances, with the aim of informing studies on the molecular pathogenesis of SS and the exploration of precision treatment strategies.

导出引用

莫国生, 马云婷, 桂宝恒. 生长板功能调控与身材矮小症的相关研究及治疗进展[J]. 中国当代儿科杂志. 2026, 28(9): 1150-1156 https://doi.org/10.7499/j.issn.1008-8830.2605062

Guo-Sheng MO, Yun-Ting MA, Bao-Heng GUI. Growth plate regulation and short stature: mechanistic insights and therapeutic advances[J]. Chinese Journal of Contemporary Pediatrics. 2026, 28(9): 1150-1156 https://doi.org/10.7499/j.issn.1008-8830.2605062

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