Risk factors for preterm birth: a prospective cohort study

YE Chang-Xiang; CHEN Sheng-Bao; WANG Ting-Ting; ZHANG Sen-Mao; QIN Jia-Bi; CHEN Li-Zhang

doi:10.7499/j.issn.1008-8830.2108015

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Chinese Journal of Contemporary Pediatrics ›› 2021, Vol. 23 ›› Issue (12) : 1242-1249. DOI: 10.7499/j.issn.1008-8830.2108015

CLINICAL RESEARCH

Risk factors for preterm birth: a prospective cohort study

YE Chang-Xiang, CHEN Sheng-Bao, WANG Ting-Ting, ZHANG Sen-Mao, QIN Jia-Bi, CHEN Li-Zhang

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Abstract

Objective To investigate the incidence of preterm birth and risk factors for preterm birth. Methods A prospective cohort study was performed for the pregnant women in early pregnancy and their spouses, who underwent prenatal examination for the first time in Hunan Provincial Maternal and Child Health Care Hospital from May 2014 to December 2016 and decided to be hospitalized for delivery. A questionnaire survey was performed to collect exposure information possibly related to preterm birth. The hospital's medical record system was used for information verification and to record the pregnancy outcome. A multivariate logistic regression analysis was used to investigate the risk factors for preterm birth. Results A total of 6 764 pregnant women with complete data were included, and the incidence rate of preterm birth was 17.09%. The multivariate logistic regression analysis showed that a history of adverse pregnancy outcomes, eating areca nut before pregnancy, a history of pregnancy complications, a history of hepatitis, no folate supplementation during pregnancy, medication during pregnancy, active smoking and passive smoking during pregnancy, drinking during pregnancy, unbalanced diet during pregnancy, high-intensity physical activity during pregnancy, and natural conception after treatment of infertility or assisted conception as the way of conception were risk factors for preterm birth (P<0.05). Additionally, the pregnant women whose spouses were older, had a higher body mass index or smoked had an increased risk for preterm birth (P<0.05). A higher level of education of pregnant women or their spouses and lower gravidity were protective factors against preterm birth (P<0.05). Conclusions There are many risk factors for preterm birth. Special attention should be paid to the life behaviors of pregnant women during pregnancy, and health education should be strengthened for pregnant women and their spouses to develop good living habits and reduce the incidence of preterm births.

Key words

Preterm birth / Risk factor / Prospective cohort study / Pregnant woman

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YE Chang-Xiang, CHEN Sheng-Bao, WANG Ting-Ting, ZHANG Sen-Mao, QIN Jia-Bi, CHEN Li-Zhang. Risk factors for preterm birth: a prospective cohort study[J]. Chinese Journal of Contemporary Pediatrics. 2021, 23(12): 1242-1249 https://doi.org/10.7499/j.issn.1008-8830.2108015

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