Effect of gonadotropin-releasing hormone analogue treatment in improving final adult height of children with central precocious puberty or early and fast puberty: a Meta analysis

CHU Zhao-Le; JIANG Hui; WU Qian

doi:10.7499/j.issn.1008-8830.2108078

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Chinese Journal of Contemporary Pediatrics ›› 2021, Vol. 23 ›› Issue (11) : 1161-1168. DOI: 10.7499/j.issn.1008-8830.2108078

CLINICAL RESEARCH

Effect of gonadotropin-releasing hormone analogue treatment in improving final adult height of children with central precocious puberty or early and fast puberty: a Meta analysis

CHU Zhao-Le, JIANG Hui, WU Qian

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Abstract

Objective To systematically evaluate the effect of gonadotropin-releasing hormone analogue (GnRHa) treatment on the final adult height of children over 6 years of age with central precocious puberty (CPP) or early and fast puberty (EFP). Methods PubMed, MEDLINE, Embase, Cochrane Library, CNKI, and Wanfang Data were searched for related articles on GnRHa treatment for children with CPP or EFP. Stata 12.0 software was used to perform a Meta analysis of related data. Results A total of 10 studies were included, and the total sample size was 720 children, with 475 children in the GnRHa treatment group and 245 children in the control group. The Meta analysis showed that compared with the control group, the GnRHa treatment group had significantly better final adult height (WMD=3.30, 95%CI: 2.49-4.12, P<0.001), standard deviation score of final adult height (WMD=0.51, 95%CI: 0.29-0.73, P<0.001), and height gain (WMD=2.89, 95%CI: 2.17-3.60, P<0.001). No severe adverse events were reported in these studies. Conclusions GnRHa treatment is safe and effective in improving the final adult height of children over 6 years of age with CPP or EFP. Citation:

Key words

Central precocious puberty / Early and fast puberty / Gonadotropin-releasing hormone analogue / Final adult height / Meta analysis / Child

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CHU Zhao-Le, JIANG Hui, WU Qian. Effect of gonadotropin-releasing hormone analogue treatment in improving final adult height of children with central precocious puberty or early and fast puberty: a Meta analysis[J]. Chinese Journal of Contemporary Pediatrics. 2021, 23(11): 1161-1168 https://doi.org/10.7499/j.issn.1008-8830.2108078

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