Long-term effect of active parenteral nutrition support regimen in preterm infants with a gestational age of &lt;34 weeks

JIANG Ren-Hui; SHEN Yu-Jie; LIU Xiao-Chen; LI Lu-Quan; CHENG Qian

doi:10.7499/j.issn.1008-8830.2108113

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Chinese Journal of Contemporary Pediatrics ›› 2021, Vol. 23 ›› Issue (12) : 1221-1227. DOI: 10.7499/j.issn.1008-8830.2108113

CLINICAL RESEARCH

Long-term effect of active parenteral nutrition support regimen in preterm infants with a gestational age of <34 weeks

JIANG Ren-Hui, SHEN Yu-Jie, LIU Xiao-Chen, LI Lu-Quan, CHENG Qian

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Abstract

Objective To study the long-term effect of active parenteral nutrition support regimen in preterm infants with a gestational age of <34 weeks. Methods According to the different doses of fat emulsion and amino acids used in the early stage, the preterm infants with a gestational age of <34 weeks, who were admitted to the hospital within 24 hours after birth from May to December 2019, were divided into an active parenteral nutrition group and a conventional parenteral nutrition group (n=50). Physical indices and the measurements of the Gesell Development Scale were collected at the age of 6 months and 13 months. Results At the age of 6 months, the active parenteral nutrition group (n=46) had higher developmental quotients of gross motor, fine motor, and personal-social behavior than the conventional parenteral nutrition group (n=34) (P<0.05). At the age of 13 months, the active parenteral nutrition group (n=25) had higher developmental quotients of adaptive behavior, gross motor, and personal-social behavior than the conventional parenteral nutrition group (n=19) (P<0.05). There were no significant differences in the physical development indices such as body weight, body height, and head circumference between the two groups during follow-up (P>0.05). Conclusions For preterm infants with a gestational age of <34 weeks, an active parenteral nutrition support strategy with high doses of fat emulsion and amino acids within 24 hours after birth can improve their long-term neurodevelopment.

Key words

Parenteral nutrition / Amino acid / Fat emulsion / Neurodevelopment / Preterm infant

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JIANG Ren-Hui, SHEN Yu-Jie, LIU Xiao-Chen, LI Lu-Quan, CHENG Qian. Long-term effect of active parenteral nutrition support regimen in preterm infants with a gestational age of <34 weeks[J]. Chinese Journal of Contemporary Pediatrics. 2021, 23(12): 1221-1227 https://doi.org/10.7499/j.issn.1008-8830.2108113

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