Risk factors for peripherally inserted central catheterization-associated bloodstream infection in neonates

XU Yan-Ping; SHANG Zhen-Ru; Dorazio Robert M.; SHI Li-Ping

doi:10.7499/j.issn.1008-8830.2109147

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (2) : 141-146. DOI: 10.7499/j.issn.1008-8830.2109147

CLINICAL RESEARCH

Risk factors for peripherally inserted central catheterization-associated bloodstream infection in neonates

XU Yan-Ping, SHANG Zhen-Ru, Dorazio Robert M., SHI Li-Ping

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Abstract

Objective To study the features of catheter-related bloodstream infection (CRBSI) or central line-associated bloodstream infection (CLABSI) after peripherally inserted central catheterization (PICC) in neonates admitted to the neonatal intensive care unit (NICU) and the risk factors for CRBSI or CLABSI. Methods A retrospective analysis was performed on the medical data of the neonates who were treated and required PICC in the NICU of the Children's Hospital, Zhejiang University School of Medicine from June 1, 2018 to May 1, 2020. The catheterization-related data were collected, including placement time, insertion site, removal time, and antimicrobial lock of PICC. The multivariate logistic regression model was used to investigate the risk factors for CRBSI or CLABSI in the neonates. Results A total of 446 neonates were enrolled, with a mean gestational age of (30.8±4.0) weeks, a mean birth weight of (1 580±810) g, a median age of 9 days, and a median duration of PICC of 18 days. The incidence rates of CLABSI and CRBSI were 5.6 and 1.46 per 1 000 catheter days, respectively. Common pathogens for CLABSI caused by PICC included Staphylococcus epidermidis (n=19) and Klebsiella pneumoniae (n=11), and those for CRBSI caused by PICC included Klebsiella pneumoniae (n=6). The risk of CLABSI caused by PICC increased significantly with prolonged durations of PICC and antibiotic use, and the PICC-related infection probability at head and neck was significantly lower than that in the upper and low limbs (P<0.05), while the above conditions were more obvious in neonates with a birth weight of <1 500 g. The risk of CRBSI caused by PICC decreased with the increase in gestational age (P<0.05). Conclusions CRBSI and CLABSI remain serious issues in NICU nosocomial infection. The identification of the risk factors for CRBSI and CLABSI provides a basis for improving the quality of clinical care and management.

Key words

Central line-associated bloodstream infection / Neonatal intensive care unit / Peripherally inserted central catheterization / Neonate

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XU Yan-Ping, SHANG Zhen-Ru, Dorazio Robert M., SHI Li-Ping. Risk factors for peripherally inserted central catheterization-associated bloodstream infection in neonates[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(2): 141-146 https://doi.org/10.7499/j.issn.1008-8830.2109147

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