Recent research on the application of biologics in the treatment of multisystem inflammatory syndrome in children after SARS-CoV-2 infection

CUI Han-Yu; HU Chang-Ping

doi:10.7499/j.issn.1008-8830.2111005

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (2) : 216-222. DOI: 10.7499/j.issn.1008-8830.2111005

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Recent research on the application of biologics in the treatment of multisystem inflammatory syndrome in children after SARS-CoV-2 infection

CUI Han-Yu, HU Chang-Ping

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Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a type of hyperinflammatory symptoms similar to Kawasaki disease after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is commonly observed in children aged 8-10 years. Primary therapeutic medications for MIS-C are intravenous immunoglobulins and glucocorticoids. It has been reported that biologics, such as IL-1 receptor antagonist anakinra, IL-6 receptor antagonist tocilizumab, and TNF-α receptor antagonist infliximab, can be used as an option for critically ill patients. This article elaborates on the mechanism of action of the above biologics and discusses the efficacy and safety biologics in the treatment of MIS-C after SARS-CoV-2 infection, in order to provide methods for the treatment of MIS-C with severe symptoms.

Key words

Multisystem inflammatory syndrome / Severe acute respiratory syndrome coronavirus 2 / Biologics / Child

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CUI Han-Yu, HU Chang-Ping. Recent research on the application of biologics in the treatment of multisystem inflammatory syndrome in children after SARS-CoV-2 infection[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(2): 216-222 https://doi.org/10.7499/j.issn.1008-8830.2111005

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