Monitoring of gastrointestinal dysfunction by near-infrared spectroscopy in children with sepsis: a prospective study

YAO De-Zhen; WANG Li-Jie

doi:10.7499/j.issn.1008-8830.2202099

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (6) : 620-625. DOI: 10.7499/j.issn.1008-8830.2202099

CLINICAL RESEARCH

Monitoring of gastrointestinal dysfunction by near-infrared spectroscopy in children with sepsis: a prospective study

YAO De-Zhen, WANG Li-Jie

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Abstract

Objective To investigate the incidence and mortality of gastrointestinal dysfunction in children with sepsis, the application of near-infrared spectroscopy (NIRS) in monitoring mesenteric regional tissue oxygen saturation (rSO₂), and the association between rSO₂ and gastrointestinal dysfunction. Methods In this prospective study, 79 children with sepsis in the pediatric intensive care unit (sepsis group) and 40 children who underwent physical examination in the Department of Child Healthcare (healthy control group) from January to December, 2021 were enrolled as subjects. The related medical data were collected, including general information on admission and at discharge, treatment during hospitalization, and laboratory examination results. NIRS was used to measure mesenteric rSO₂. Clinical characteristics were compared between the patients with and without gastrointestinal dysfunction. Results For the 79 children with sepsis, the incidence rate of gastrointestinal dysfunction was 49% (39/79), and the mortality rate of the children with gastrointestinal dysfunction was 26% (10/39). The children with gastrointestinal dysfunction had a longer duration of mechanical ventilation and a higher 28-day mortality rate (P<0.05). The children with gastrointestinal dysfunction had a significantly lower median rSO₂ (64%) than the children without gastrointestinal dysfunction (72%) and the healthy control group (78%) (P<0.05). Conclusions There are high incidence and mortality rates of gastrointestinal dysfunction in children with sepsis, and the reduction in rSO₂ may be associated with the development of gastrointestinal dysfunction.

Key words

Sepsis / Gastrointestinal dysfunction / Near-infrared spectroscopy / Child

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YAO De-Zhen, WANG Li-Jie. Monitoring of gastrointestinal dysfunction by near-infrared spectroscopy in children with sepsis: a prospective study[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(6): 620-625 https://doi.org/10.7499/j.issn.1008-8830.2202099

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