Association between paternal age at childbirth and autism spectrum disorder in offspring

PAN Ning; LIN Li-Zi; WANG Xin; GUO Cui-Hua; JING Jin; LI Xiu-Hong

doi:10.7499/j.issn.1008-8830.2203146

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (8) : 863-868. DOI: 10.7499/j.issn.1008-8830.2203146

CLINICAL RESEARCH

Association between paternal age at childbirth and autism spectrum disorder in offspring

PAN Ning, LIN Li-Zi, WANG Xin, GUO Cui-Hua, JING Jin, LI Xiu-Hong

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Abstract

Objective To study the association between paternal age at childbirth and the risk of autism spectrum disorder (ASD) in offspring. Methods In this cross-sectional study, 71 children with ASD who were diagnosed in the Department of Child Healthcare in six hospitals in Guangzhou, Foshan, Beijing, Wuhan, Hangzhou, and Chongqing of China from August 2016 to March 2017 were enrolled as subjects, and 284 typically developing children matched for age, sex, and maternal age at childbirth with the ASD children served as controls. A self-design questionnaire was used to collect the data on social demography, maternal pregnancy, and delivery. The association between paternal age at childbirth and the development of ASD in offspring was evaluated by the logistic regression analysis. Results After control for demographic factors and pregnancy- and delivery-related factors, the logistic regression analysis showed that a relatively high paternal age at childbirth was significantly associated with the increased risk of ASD in offspring (OR=1.12, 95%CI: 1.02-1.23, P<0.05). After grouping based on the paternal age, the logistic regression analysis showed that paternal age at childbirth of ≥40 years was significantly associated with the risk of ASD in offspring (before adjustment: OR=7.08, 95%CI: 1.77-28.32, P<0.05; after adjustment: OR=8.50, 95%CI: 1.71-42.25, P<0.05). Conclusions High paternal age at childbirth is significantly associated with the increased risk of ASD in offspring, and paternal age at childbirth ≥40 years may be the high-risk age group for ASD in offspring.

Key words

Autism spectrum disorder / Paternal age at childbirth / Child

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PAN Ning, LIN Li-Zi, WANG Xin, GUO Cui-Hua, JING Jin, LI Xiu-Hong. Association between paternal age at childbirth and autism spectrum disorder in offspring[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(8): 863-868 https://doi.org/10.7499/j.issn.1008-8830.2203146

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