Interpretation of "International guidelines regarding the role of IVIG in the management of Rh- and ABO-mediated haemolytic disease of the newborn"

HUANG Fang-Jun; HE Yang; TANG Jun; ZHANG Meng; CHEN Jian; MU De-Zhi

doi:10.7499/j.issn.1008-8830.2205158

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (11) : 1183-1188. DOI: 10.7499/j.issn.1008-8830.2205158

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Interpretation of "International guidelines regarding the role of IVIG in the management of Rh- and ABO-mediated haemolytic disease of the newborn"

HUANG Fang-Jun, HE Yang, TANG Jun, ZHANG Meng, CHEN Jian, MU De-Zhi

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Abstract

International guidelines regarding the role of intravenous immunoglobulin (IVIG) in the management of Rh- and ABO-mediated haemolytic disease of the newborn was drafted by an international panel of experts in the fields of hematology, neonatology, and blood transfusion and was published in British Journal of Haematology on March 16, 2022. The guidelines summarize the evidence-based practice of IVIG in Rh- and ABO-mediated haemolytic disease of the newborn and propose related recommendations. The guidelines recommend that IVIG should not be applied as a routine treatment regimen for Rh- and ABO-mediated haemolytic disease of the newborn in order to reduce exchange transfusion (ET), and the best time to apply IVIG remains unclear in the situations where hyperbilirubinaemia is severe (approaching or exceeding the ET threshold) or ET cannot be implemented. These guidelines are formulated with rigorous methods, but with the lower quality of evidence.

Key words

Intravenous immunoglobulin / Haemolytic disease of the newborn / International guideline / Neonate

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HUANG Fang-Jun, HE Yang, TANG Jun, ZHANG Meng, CHEN Jian, MU De-Zhi. Interpretation of "International guidelines regarding the role of IVIG in the management of Rh- and ABO-mediated haemolytic disease of the newborn"[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(11): 1183-1188 https://doi.org/10.7499/j.issn.1008-8830.2205158

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