Magnetic resonance imaging for the diagnosis of muscular dystrophy

TANG Jing; ZHANG Jia-Peng; YANG Xue-Jun; ZHONG Jing-Zi; XIE Yan-Shu; MENG Qi; LAN Dan

doi:10.7499/j.issn.1008-8830.2206052

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (11) : 1231-1237. DOI: 10.7499/j.issn.1008-8830.2206052

CLINICAL RESEARCH

Magnetic resonance imaging for the diagnosis of muscular dystrophy

TANG Jing, ZHANG Jia-Peng, YANG Xue-Jun, ZHONG Jing-Zi, XIE Yan-Shu, MENG Qi, LAN Dan

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Abstract

Objective To summarize the skeletal muscle magnetic resonance imaging (MRI) features of the lower limbs in common subtypes of muscular dystrophy (MD) and the experience in the application of MRI in the diagnosis of MD. Methods A total of 48 children with MD who were diagnosed by genetic testing were enrolled as subjects. The muscle MRI features of the lower limbs were analyzed. Cumulative fatty infiltration score was calculated for each subtype, and the correlation of cumulative fatty infiltration score with clinical indices was analyzed for Duchenne muscular dystrophy (DMD). Results DMD was characterized by the involvement of the gluteus maximus and the adductor magnus. Becker muscular dystrophy was characterized by the involvement of the vastus lateralis muscle. Limb-girdle muscular dystrophy was characterized by the involvement of the adductor magnus, the vastus intermedius, the vastus medialis, and the vastus lateralis muscle. For DMD, the cumulative fatty infiltration score of the lower limb muscles was significantly correlated with age, course of the disease, muscle strength, and motor function (P<0.05), while it was not significantly correlated with the serum creatine kinase level (P>0.05). Conclusions Different subtypes of MD have different MRI manifestations, and MRI may help with the diagnosis and assessment of MD.

Key words

Magnetic resonance imaging / Muscular dystrophy / Duchenne muscular dystrophy / Diagnosis / Child

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TANG Jing, ZHANG Jia-Peng, YANG Xue-Jun, ZHONG Jing-Zi, XIE Yan-Shu, MENG Qi, LAN Dan. Magnetic resonance imaging for the diagnosis of muscular dystrophy[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(11): 1231-1237 https://doi.org/10.7499/j.issn.1008-8830.2206052

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