Prevalence and risk factors of obesity in children with Diamond-Blackfan anemia

YI Mei-Hui; WAN Yang; CHENG Si-Qi; GONG Xiao-Wen; YIN Zi-Xi; LI Jun; GAO Yang-Yang; WU Chao; ZONG Su-Yu; CHANG Li-Xian; CHEN Yu-Mei; ZHENG Rong-Xiu; ZHU Xiao-Fan

doi:10.7499/j.issn.1008-8830.2206070

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (10) : 1143-1148. DOI: 10.7499/j.issn.1008-8830.2206070

CLINICAL RESEARCH

Prevalence and risk factors of obesity in children with Diamond-Blackfan anemia

YI Mei-Hui, WAN Yang, CHENG Si-Qi, GONG Xiao-Wen, YIN Zi-Xi, LI Jun, GAO Yang-Yang, WU Chao, ZONG Su-Yu, CHANG Li-Xian, CHEN Yu-Mei, ZHENG Rong-Xiu, ZHU Xiao-Fan

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Abstract

Objective To investigate the distribution of body mass index (BMI) and risk factors for obesity in children with Diamond-Blackfan Anemia (DBA). Methods The children with DBA who attended National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, from January 2003 to December 2020 were enrolled as subjects. The related clinical data and treatment regimens were recorded. The height and weight data measured within 1 week before or after follow-up time points were collected to calculate BMI. The risk factors for obesity were determined by multivariate regression analysis in children with DBA. Results A total of 129 children with DBA were enrolled, among whom there were 80 boys (62.0%) and 49 girls (38.0%), with a median age of 49 months (range 3-189 months). The prevalence rate of obesity was 14.7% (19/129). The multivariate logistic regression analysis showed that the absence of ribosomal protein gene mutation was closely associated with obesity in children with DBA (adjusted OR=3.63, 95%CI: 1.16-11.38, adjusted P=0.027). In children with glucocorticoid-dependent DBA, obesity was not associated with age of initiation of glucocorticoid therapy, duration of glucocorticoid therapy, and maintenance dose of glucocorticoids (P>0.05). Conclusions There is a high prevalence rate of obesity in children with DBA, and the absence of ribosomal protein gene mutation is closely associated with obesity in children with DBA.

Key words

Diamond-Blackfan anemia / Body mass index / Obesity / Ribosomal protein gene / Child

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YI Mei-Hui, WAN Yang, CHENG Si-Qi, GONG Xiao-Wen, YIN Zi-Xi, LI Jun, GAO Yang-Yang, WU Chao, ZONG Su-Yu, CHANG Li-Xian, CHEN Yu-Mei, ZHENG Rong-Xiu, ZHU Xiao-Fan. Prevalence and risk factors of obesity in children with Diamond-Blackfan anemia[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(10): 1143-1148 https://doi.org/10.7499/j.issn.1008-8830.2206070

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