Association between early-life factors and pubertal timing in girls

ZENG Ding; LIANG Jian-Ping; ZHENG Yi-Jin; DENG Na-Li; YANG Lun; LU Shuang; YANG Yi; LIU Li

doi:10.7499/j.issn.1008-8830.2208191

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (2) : 153-158. DOI: 10.7499/j.issn.1008-8830.2208191

CLINICAL RESEARCH

Association between early-life factors and pubertal timing in girls

ZENG Ding, LIANG Jian-Ping, ZHENG Yi-Jin, DENG Na-Li, YANG Lun, LU Shuang, YANG Yi, LIU Li

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Abstract

Objective To study the association between early-life factors (including birth weight, method of birth, gestational age, and history of gestational metabolic disorders) and pubertal timing in girls. Methods The stratified cluster sampling method was used to select the girls in grades 2-3 and 7-8 from three primary schools and three middle schools in Guangzhou, China from March to December, 2019, and breast development was examined for all girls. A questionnaire survey was performed to collect the information on early-life factors. The multivariate logistic regression model was used to evaluate the association of gestational metabolic disorders, birth weight, method of birth, and gestational age with pubertal timing in girls. The Bootstrap method was used to assess the mediation effect of body mass index (BMI) (Z score) between high birth weight (≥4 000 g) and pubertal timing. Results A total of 1 665 girls were enrolled, among whom 280 (16.82%) were judged to have early pubertal timing. The multivariate logistic regression analysis showed that high birth weight was associated with the increased risk of early pubertal timing (OR=2.12, 95%CI: 1.19-3.66, P=0.008). Nevertheless, no significant association was observed between other early-life factors and pubertal timing (P>0.05). The OR for the mediation effect of BMI (Z score) between high birth weight and early pubertal timing was 1.25 (95%CI: 1.09-1.47), accounting for 29.33% of the total effect of high birth weight on early pubertal timing. Conclusions High birth weight is associated with the increased risk of early pubertal timing in girls, and overweight/obesity may play a partial mediating role in the association between high birth weight and early pubertal timing in girls.

Key words

Pubertal timing / Birth weight / Gestational metabolic disorder / Body mass index / Girl

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ZENG Ding, LIANG Jian-Ping, ZHENG Yi-Jin, DENG Na-Li, YANG Lun, LU Shuang, YANG Yi, LIU Li. Association between early-life factors and pubertal timing in girls[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(2): 153-158 https://doi.org/10.7499/j.issn.1008-8830.2208191

References

1 Guerrero-Preston R, Goldman LR, Brebi-Mieville P, et al. Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds[J]. Epigenetics, 2010, 5(6): 539-546. PMID: 20523118. PMCID: PMC3322495. DOI: 10.4161/epi.5.6.12378.
2 Frontini MG, Srinivasan SR, Berenson GS. Longitudinal changes in risk variables underlying metabolic syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa heart study[J]. Int J Obes Relat Metab Disord, 2003, 27(11): 1398-1404. PMID: 14574352. DOI: 10.1038/sj.ijo.0802422.
3 Ahlgren M, Melbye M, Wohlfahrt J, et al. Growth patterns and the risk of breast cancer in women[J]. N Engl J Med, 2004, 351(16): 1619-1626. PMID: 15483280. DOI: 10.1056/NEJMoa040576.
4 Jordan SJ, Webb PM, Green AC. Height, age at menarche, and risk of epithelial ovarian cancer[J]. Cancer Epidemiol Biomarkers Prev, 2005, 14(8): 2045-2048. PMID: 16103459. DOI: 10.1158/1055-9965.EPI-05-0085.
5 Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation[J]. Mol Cell Biol, 2003, 23(15): 5293-5300. PMID: 12861015. PMCID: PMC165709. DOI: 10.1128/MCB.23.15.5293-5300.2003.
6 Ibá?ez L, de Zegher F. Puberty after prenatal growth restraint[J]. Horm Res, 2006, 65 Suppl 3: 112-115. PMID: 16612123. DOI: 10.1159/000091515.
7 单杰, 周夙妹, 方姣, 等. 剖宫产分娩对男女童青春期发育影响的队列研究[J]. 中国学校卫生, 2019, 40(5): 658-661. DOI: 10.16835/j.cnki.1000-9817.2019.05.006.
8 杨博, 刘琴, 刘舒丹, 等. 青春发动时相提前影响因素的系统评价[J]. 中国循证医学杂志, 2018, 18(12): 1337-1351. DOI: 10.7507/1672-2531.201708063.
9 管佩钰, 王宏, 郭靖, 等. 重庆市儿童青少年青春发动时相与肥胖及体成分的关系[J]. 卫生研究, 2016, 45(4): 568-573. PMID: 29903324. DOI: 10.19813/j.cnki.weishengyanjiu.2016.04.034.
10 罗燕, 刘琴, 文一, 等. 重庆城区小学儿童青春发动时相提前影响因素分析[J]. 卫生研究, 2016, 45(3): 430-435. PMID: 27459807. DOI: 10.19813/j.cnki.weishengyanjiu.2016.03.013.
11 许媛媛, 孙丽, 郭欣, 等. 超重肥胖与青少年青春发动时相的关联及性别差异研究[J]. 中华预防医学杂志, 2017, 51(9): 792-795. PMID: 28881543. DOI: 10.3760/cma.j.issn.0253-9624.2017.09.004.
12 姚幸村. 青春发动时相提前与肥胖关联性追踪调查[D]. 郑州: 郑州大学, 2018.
13 Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls[J]. Arch Dis Child, 1969, 44(235): 291-303. PMID: 5785179. PMCID: PMC2020314. DOI: 10.1136/adc.44.235.291.
14 柯亚亚, 白宇翔, 漆洪波. 美国妇产科医师学会“晚期足月和过期妊娠指南2014版”要点解读[J]. 中国实用妇科与产科杂志, 2015, 31(2): 105-108. DOI: 10.7504/fk2015010121.
15 赵丽琴, 郭遂群, 林莉. 延期妊娠对羊水过少患者妊娠结局的影响[J]. 实用妇产科杂志, 2013, 29(6): 454-456. DOI: 10.3969/j.issn.1003-6946.2013.06.019.
16 谢幸, 苟文丽, 林仲秋, 等. 妇产科学[M]. 8版. 北京: 人民卫生出版社, 2013: 113-116.
17 中华人民共和国国家卫生和计划生育委员会. 学龄儿童青少年超重与肥胖筛查: WS/T 586-2018[S]. 北京: 中国标准出版社, 2018.
18 陶芳标. 青春发动时相提前与青少年卫生系列述评（1）: 早期生长模式与青春发动时相提前[J]. 中国学校卫生, 2008, 29(3): 193-195. DOI: 10.3969/j.issn.1000-9817.2008.03.001.
19 方杰, 温忠麟, 张敏强. 类别变量的中介效应分析[J]. 心理科学, 2017, 40(2): 471-477. DOI: 10.16719/j.cnki.1671-6981.20170233.
20 Olivo-Marston S, Graubard BI, Visvanathan K, et al. Gender-specific differences in birthweight and the odds of puberty: NHANES III, 1988-94[J]. Paediatr Perinat Epidemiol, 2010, 24(3): 222-231. PMID: 20415751. PMCID: PMC4119173. DOI: 10.1111/j.1365-3016.2010.01097.x.
21 张莹, 马佳男, 王佳丽, 等. 生命早期应激对青春期雄性大鼠下丘脑-垂体-性腺轴的影响[J]. 生殖医学杂志, 2021, 30(11): 1500-1505. DOI: 10.3969/j.issn.1004-3845.2021.11.016.
22 张广川, 梁健平, 杨轮, 等. 出生体重及分娩方式对广州市小学生肥胖的影响[J]. 中国学校卫生, 2021, 42(2): 277-281. DOI: 10.16835/j.cnki.1000-9817.2021.02.029.
23 杨轮, 梁健平, 敖丽萍, 等. 母亲孕期被动吸烟与女生超重肥胖对月经初潮提前的影响[J]. 中国学校卫生, 2020, 41(7): 1012-1014. DOI: 10.16835/j.cnki.1000-9817.2020.07.015.
24 冯永亮, 彭婷婷, 王芳, 等. 妊娠期高血压疾病对出生结局的影响及相关因素[J]. 中华疾病控制杂志, 2014, 18(2): 131-134.
25 李昭润, 蒋泓, 钱序. 孕前体质量指数对妊娠期疾病及妊娠结局的影响[J]. 上海预防医学, 2020, 32(7): 545-553. DOI: 10.19428/j.cnki.sjpm.2020.19927.
26 蒋优君, 毛华庆, 梁黎, 等. 孕母患自身免疫性甲状腺疾病对新生儿出生体重及甲状腺功能的影响[J]. 中国实用儿科杂志, 2003, 18(11): 673-675. DOI: 10.3969/j.issn.1005-2224.2003.11.013.