Relationship between skeletal muscle mass index and metabolic phenotypes of obesity in adolescents

TONG Ling-Ling; MA Xiao-Yan; TIAN Mei; DING Wen-Qing

doi:10.7499/j.issn.1008-8830.2211005

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (5) : 457-462. DOI: 10.7499/j.issn.1008-8830.2211005

CLINICAL RESEARCH

Relationship between skeletal muscle mass index and metabolic phenotypes of obesity in adolescents

TONG Ling-Ling^1,2, MA Xiao-Yan^1,2, TIAN Mei^1,2, DING Wen-Qing^1,2

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Abstract

Objective To study the relationship between skeletal muscle mass index (SMI) and metabolic phenotypes of obesity in adolescents, and to provide a basis for the prevention and control of adolescent obesity and related metabolic diseases. Methods A total of 1 352 adolescents aged 12 to 18 years were randomly selected by stratified cluster sampling in Yinchuan City from October 2017 to September 2020, and they were surveyed using questionnaires, physical measurements, body composition measurements, and laboratory tests. According to the diagnostic criteria for metabolic abnormalities and the definition of obesity based on the body mass index, the subjects were divided into four metabolic phenotypes: metabolically healthy normal weight, metabolically healthy obesity, metabolically unhealthy normal weight, and metabolically unhealthy obesity. The association between SMI and the metabolic phenotypes was analyzed using multivariate logistic regression. Results The SMI level in the metabolically unhealthy normal weight, metabolically healthy obesity, and metabolically unhealthy obesity groups was lower than that in the metabolically healthy normal weight group (P<0.001). Multivariate logistic regression analysis showed that after adjusting for gender and age, a higher SMI level was a protective factors for adolescents to develop metabolic unhealthy normal weight, metabolically healthy obesity, and metabolically unhealthy obesity phenotypes (OR=0.74, 0.60, and 0.54, respectively; P<0.001). Conclusions Increasing SMI can reduce the risk of the development of metabolic unhealthy/obesity.

Key words

Obesity / Metabolic phenotype / Skeletal mass index / Adolescent

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TONG Ling-Ling, MA Xiao-Yan, TIAN Mei, DING Wen-Qing. Relationship between skeletal muscle mass index and metabolic phenotypes of obesity in adolescents[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(5): 457-462 https://doi.org/10.7499/j.issn.1008-8830.2211005

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