Recent research on the epidemiology and preventive strategies of neonatal group B Streptococcus infection in the latest decade

GUO Meng-Yang; GAO Wei; YUAN Lin; YAO Kai-Hu

doi:10.7499/j.issn.1008-8830.2211140

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (5) : 534-540. DOI: 10.7499/j.issn.1008-8830.2211140

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Recent research on the epidemiology and preventive strategies of neonatal group B Streptococcus infection in the latest decade

GUO Meng-Yang, GAO Wei, YUAN Lin, YAO Kai-Hu

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Abstract

Currently, the main strategy for preventing neonatal group B Streptococcus (GBS) infection is prenatal screening combined with intrapartum antibiotic prophylaxis, which has effectively reduced the incidence of neonatal GBS early-onset disease. However, the burden of GBS infection is still significant. The intrapartum antibiotic prophylaxis strategy has limitations such as inducing antibiotic resistance and inability to effectively prevent GBS late-onset disease. It is crucial to develop and evaluate other prevention strategies, while paying close attention to assessing penicillin allergy in pregnant women and how to prevent GBS infection in neonates with negative maternal GBS screening. In recent years, there has been some progress in GBS vaccines and related immunological research, and the use of specific vaccines is expected to significantly reduce GBS infection in neonates.

Key words

Group B Streptococcus / Intrapartum antibiotic prophylaxis / Prevention / Vaccine / Neonate

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GUO Meng-Yang, GAO Wei, YUAN Lin, YAO Kai-Hu. Recent research on the epidemiology and preventive strategies of neonatal group B Streptococcus infection in the latest decade[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(5): 534-540 https://doi.org/10.7499/j.issn.1008-8830.2211140

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