Value of serum fibroblast growth factor 23 in diagnosis of hypophosphatemic rickets in children

DONG Sha-Sha; CHE Ruo-Chen; ZHENG Bi-Xia; ZHANG Ai-Hua; WANG Chun-Li; BAI Mi; CHEN Ying

doi:10.7499/j.issn.1008-8830.2303016

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (7) : 705-710. DOI: 10.7499/j.issn.1008-8830.2303016

CLINICAL RESEARCH

Value of serum fibroblast growth factor 23 in diagnosis of hypophosphatemic rickets in children

DONG Sha-Sha, CHE Ruo-Chen, ZHENG Bi-Xia, ZHANG Ai-Hua, WANG Chun-Li, BAI Mi, CHEN Ying

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Abstract

Objective To study the value of serum fibroblast growth factor 23 (FGF23) in the diagnosis of hypophosphatemic rickets in children. Methods A total of 28 children who were diagnosed with hypophosphatemic rickets in Children's Hospital of Nanjing Medical University from January 2016 to June 2021 were included as the rickets group. Forty healthy children, matched for sex and age, who attended the Department of Child Healthcare of the hospital were included as the healthy control group. The serum level of FGF23 was compared between the two groups, and the correlations of the serum FGF23 level with clinical characteristics and laboratory test results were analyzed. The value of serum FGF23 in the diagnosis of hypophosphatemic rickets was assessed. Results The rickets group had a significantly higher serum level of FGF23 than the healthy control group (P<0.05). In the rickets group, the serum FGF23 level was positively correlated with the serum alkaline phosphatase level (r_s=0.38, P<0.05) and was negatively correlated with maximum renal tubular phosphorus uptake/glomerular filtration rate (r_s=-0.64, P<0.05), while it was not correlated with age, height Z-score, sex, and parathyroid hormone (P>0.05). Serum FGF23 had a sensitivity of 0.821, a specificity of 0.925, an optimal cut-off value of 55.77 pg/mL, and an area under the curve of 0.874 in the diagnosis of hypophosphatemic rickets (P<0.05). Conclusions Serum FGF23 is of valuable in the diagnosis of hypophosphatemic rickets in children, which providing a theoretical basis for early diagnosis of this disease in clinical practice.

Key words

Fibroblast growth factor 23 / Hypophosphatemic rickets / PHEX gene / Early diagnosis / Child

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DONG Sha-Sha, CHE Ruo-Chen, ZHENG Bi-Xia, ZHANG Ai-Hua, WANG Chun-Li, BAI Mi, CHEN Ying. Value of serum fibroblast growth factor 23 in diagnosis of hypophosphatemic rickets in children[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(7): 705-710 https://doi.org/10.7499/j.issn.1008-8830.2303016

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