Recent research on inhaled nitric oxide in preterm infants with a gestational age of &lt;34 weeks

LIANG Guo-Bao; LIN Xin-Zhu

doi:10.7499/j.issn.1008-8830.2303146

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (9) : 982-988. DOI: 10.7499/j.issn.1008-8830.2303146

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Recent research on inhaled nitric oxide in preterm infants with a gestational age of <34 weeks

LIANG Guo-Bao, LIN Xin-Zhu

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Abstract

Nitric oxide is a messenger molecule for vasodilation of vascular smooth muscle cells, and inhaled nitric oxide (iNO) can dilate pulmonary blood vessels and reduce pulmonary vascular resistance, thereby reducing pulmonary artery pressure, but with no influence on systemic circulation pressure. Guidelines in China and overseas recommend the use of iNO in full-term infants and late preterm infants, and it has been proved that it has a marked effect on persistent pulmonary hypertension and hypoxic respiratory failure in such infants. However, recent studies have shown that there is an increase in the off-label use of iNO in preterm infants with a gestational age of <34 weeks. This article reviews the research progress on the efficacy, safety, timing, dose, and withdrawal mode of iNO and its combination with vasoactive drugs in the treatment of preterm infants with a gestational age of <34 weeks in China and overseas, so as to provide a reference for clinical application.

Key words

Nitric oxide / Pulmonary hypertension / Hypoxic respiratory failure / Efficacy / Preterm infant

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LIANG Guo-Bao, LIN Xin-Zhu. Recent research on inhaled nitric oxide in preterm infants with a gestational age of <34 weeks[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(9): 982-988 https://doi.org/10.7499/j.issn.1008-8830.2303146

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