1 李丽香, 林淑珍, 张任攀, 等. 中国农村儿童哮喘患病情况的Meta分析[J]. 中国当代儿科杂志, 2020, 22(4): 380-386. PMID: 32312379. PMCID: PMC7389704. DOI: 10.7499/j.issn.1008-8830.1910164.
2 Stikker BS, Hendriks RW, Stadhouders R. Decoding the genetic and epigenetic basis of asthma[J]. Allergy, 2023, 78(4): 940-956. PMID: 36727912. DOI: 10.1111/all.15666.
3 Paciência I, Cavaleiro Rufo J, Moreira A. Environmental inequality: air pollution and asthma in children[J]. Pediatr Allergy Immunol, 2022, 33(6): e13818. PMID: 35754123. DOI: 10.1111/pai.13818.
4 van Meel ER, Mensink-Bout SM, den Dekker HT, et al. Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children[J]. Eur Respir J, 2022, 60(4): 2102395. PMID: 35487537. PMCID: PMC9535116. DOI: 10.1183/13993003.02395-2021.
5 Alwarith J, Kahleova H, Crosby L, et al. The role of nutrition in asthma prevention and treatment[J]. Nutr Rev, 2020, 78(11): 928-938. PMID: 32167552. PMCID: PMC7550896. DOI: 10.1093/nutrit/nuaa005.
6 Arrieta MC, Stiemsma LT, Dimitriu PA, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma[J]. Sci Transl Med, 2015, 7(307): 307ra152. PMID: 26424567. DOI: 10.1126/scitranslmed.aab2271.
7 Whiteside SA, McGinniss JE, Collman RG. The lung microbiome: progress and promise[J]. J Clin Invest, 2021, 131(15): e150473. PMID: 34338230. PMCID: PMC8321564. DOI: 10.1172/JCI150473.
8 康小会, 曹玲. 对儿童哮喘个体精准治疗若干问题的思考[J]. 中国实用儿科杂志, 2020, 35(3): 191-195. DOI: 10.19538/j.ek2020030606.
9 Chiu CJ, Huang MT. Asthma in the precision medicine era: biologics and probiotics[J]. Int J Mol Sci, 2021, 22(9): 4528. PMID: 33926084. PMCID: PMC8123613. DOI: 10.3390/ijms22094528.
10 Taylor SL, Leong LEX, Choo JM, et al. Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology[J]. J Allergy Clin Immunol, 2018, 141(1): 94-103.e15. PMID: 28479329. DOI: 10.1016/j.jaci.2017.03.044.
11 Huynh M, Crane MJ, Jamieson AM. The lung, the niche, and the microbe: exploring the lung microbiome in cancer and immunity[J]. Front Immunol, 2022, 13: 1094110. PMID: 36733391. PMCID: PMC9888758. DOI: 10.3389/fimmu.2022.1094110.
12 Natalini JG, Singh S, Segal LN. The dynamic lung microbiome in health and disease[J]. Nat Rev Microbiol, 2023, 21(4): 222-235. PMID: 36385637. PMCID: PMC9668228. DOI: 10.1038/s41579-022-00821-x.
13 Valverde-Molina J, García-Marcos L. Microbiome and asthma: microbial dysbiosis and the origins, phenotypes, persistence, and severity of asthma[J]. Nutrients, 2023, 15(3): 486. PMID: 36771193. PMCID: PMC9921812. DOI: 10.3390/nu15030486.
14 Man WH, de SteenhuijsenPiters WA, Bogaert D. The microbiota of the respiratory tract: gatekeeper to respiratory health[J]. Nat Rev Microbiol, 2017, 15(5): 259-270. PMID: 28316330. PMCID: PMC7097736. DOI: 10.1038/nrmicro.2017.14.
15 Hou K, Wu ZX, Chen XY, et al. Microbiota in health and diseases[J]. Signal Transduct Target Ther, 2022, 7(1): 135. PMID: 35461318. PMCID: PMC9034083. DOI: 10.1038/s41392-022-00974-4.
16 Pattaroni C, Watzenboeck ML, Schneidegger S, et al. Early-life formation of the microbial and immunological environment of the human airways[J]. Cell Host Microbe, 2018, 24(6): 857-865.e4. PMID: 30503510. DOI: 10.1016/j.chom.2018.10.019.
17 Wypych TP, Wickramasinghe LC, Marsland BJ. The influence of the microbiome on respiratory health[J]. Nat Immunol, 2019, 20(10): 1279-1290. PMID: 31501577. DOI: 10.1038/s41590-019-0451-9.
18 Dick S, Turner S. The airway microbiome and childhood asthma-what is the link?[J]. Acta Med Acad, 2020, 49(2):156-163. PMID: 33189121. DOI: 10.5644/ama2006-124.294.
19 Wenzel SE. Asthma: defining of the persistent adult phenotypes[J]. Lancet, 2006, 368(9537): 804-813. PMID: 16935691. DOI: 10.1016/S0140-6736(06)69290-8.
20 Conrad LA, Cabana MD, Rastogi D. Defining pediatric asthma: phenotypes to endotypes and beyond[J]. Pediatr Res, 2021, 90(1): 45-51. PMID: 33173175. PMCID: PMC8107196. DOI: 10.1038/s41390-020-01231-6.
21 Busse WW, Kraft M, Rabe KF, et al. Understanding the key issues in the treatment of uncontrolled persistent asthma with type 2 inflammation[J]. Eur Respir J, 2021, 58(2): 2003393. PMID: 33542055. PMCID: PMC8339540. DOI: 10.1183/13993003.03393-2020.
22 LeMessurier KS, Samarasinghe AE. Eosinophils: nemeses of pulmonary pathogens?[J]. Curr Allergy Asthma Rep, 2019, 19(8): 36. PMID: 31218528. PMCID: PMC6993982. DOI: 10.1007/s11882-019-0867-1.
23 Bisgaard H, Hermansen MN, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates[J]. N Engl J Med, 2007, 357(15): 1487-1495. PMID: 17928596. DOI: 10.1056/NEJMoa052632.
24 Chun Y, Do A, Grishina G, et al. Integrative study of the upper and lower airway microbiome and transcriptome in asthma[J]. JCI insight, 2020, 5(5): e133707. PMID: 32161195. PMCID: PMC7141394. DOI: 10.1172/jci.insight.133707.
25 Bourgoin-Heck M, Duféal M, Saf S, et al. Staphylococcal sensitization: a correlate of type 2-high inflammation in children with severe asthma[J]. J Allergy Clin Immunol Pract, 2023, 11(2):564-571.e1. PMID: 37113036. DOI: 10.1016/j.jaip.2022.10.026.
26 McCauley K, Durack J, Valladares R, et al. Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma[J]. J Allergy Clin Immunol, 2019, 144(5): 1187-1197. PMID: 31201890. PMCID: PMC6842413. DOI: 10.1016/j.jaci.2019.05.035.
27 韩蕾, 张旻. 非2型哮喘的发病机制及治疗研究进展[J]. 国际呼吸杂志, 2021, 41(1): 47-52. DOI: 10.3760/cma.j.cn131368-20200401-00239.
28 Ray A, Kolls JK. Neutrophilic inflammation in asthma and association with disease severity[J]. Trends Immunol, 2017, 38(12): 942-954. PMID: 28784414. PMCID: PMC5711587. DOI: 10.1016/j.it.2017.07.003.
29 Hossain FMA, Choi JY, Uyangaa E, et al. The interplay between host immunity and respiratory viral infection in asthma exacerbation[J]. Immune Netw, 2019, 19(5): e31. PMID: 31720042. PMCID: PMC6829071. DOI: 10.4110/in.2019.19.e31.
30 Green BJ, Wiriyachaiporn S, Grainge C, et al. Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma[J]. PLoS One, 2014, 9(6): e100645. PMID: 24955983. PMCID: PMC4067344. DOI: 10.1371/journal.pone.0100645.
31 Marathe SJ, Snider MA, Flores-Torres AS, et al. Human matters in asthma: considering the microbiome in pulmonary health[J]. Front Pharmacol, 2022, 13: 1020133. PMID: 36532717. PMCID: PMC9755222. DOI: 10.3389/fphar.2022.1020133.
32 Patel KK, Vicencio AG, Du Z, et al. Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma[J]. Pediatr Infect Dis J, 2010, 29(12): 1093-1098. PMID: 21155094. DOI: 10.1097/inf.0b013e3181eaebdc.
33 Papaioannou AI, Fouka E, Ntontsi P, et al. Paucigranulocyticasthma: potential pathogenetic mechanisms, clinical features and therapeutic management[J]. J Pers Med, 2022, 12(5):850. PMID: 35629272. PMCID: PMC9145917. DOI: 10.3390/jpm12050850.
34 Tliba O, Panettieri RAJr . Paucigranulocytic asthma: uncoupling of airway obstruction from inflammation[J]. J Allergy Clin Immunol, 2019, 143(4): 1287-1294. PMID: 29928921. PMCID: PMC6301131. DOI: 10.1016/j.jaci.2018.06.008.
35 Son JH, Kim JH, Chang HS, et al. Relationship of microbial profile with airway immune response in eosinophilic or neutrophilic inflammation of asthmatics[J]. Allergy Asthma Immunol Res, 2020, 12(3): 412-429. PMID: 32141256. PMCID: PMC7061157. DOI: 10.4168/aair.2020.12.3.412.
36 Durack J, Lynch SV, Nariya S, et al. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment[J]. J Allergy Clin Immunol, 2017, 140(1): 63-75. PMID: 27838347. PMCID: PMC5502827. DOI: 10.1016/j.jaci.2016.08.055.
37 Singanayagam A, Glanville N, Cuthbertson L, et al. Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease[J]. Sci Transl Med, 2019, 11(507): eaav3879. PMID: 31462509. PMCID: PMC7237237. DOI: 10.1126/scitranslmed.aav3879.
38 Dang AT, Marsland BJ. Microbes, metabolites, and the gut-lung axis[J]. Mucosal Immunol, 2019, 12(4):843-850. PMID: 30976087. DOI: 10.1038/s41385-019-0160-6.
39 Wei X, Jiang P, Liu J, et al. Association between probiotic supplementation and asthma incidence in infants: a meta-analysis of randomized controlled trials[J]. J Asthma, 2020, 57(2): 167-178. PMID: 30656984. DOI: 10.1080/02770903.2018.1561893.
40 Chen N, Liu F, Gao Q, et al. A meta-analysis of probiotics for the treatment of allergic airway diseases in children and adolescents[J]. Am J Rhinol Allergy, 2022, 36(4):480-490. PMID: 35238209. DOI: 10.1177/19458924221080159.
41 Voo PY, Wu CT, Sun HL, et al. Effect of combination treatment with Lactobacillus rhamnosus and corticosteroid in reducing airway inflammation in a mouse asthma model[J]. J Microbiol Immunol Infect, 2022, 55(4): 766-776. PMID: 35487817. DOI: 10.1016/j.jmii.2022.03.006.
42 Nembrini C, Sichelstiel A, Kisielow J, et al. Bacterial-induced protection against allergic inflammation through a multicomponent immunoregulatory mechanism[J]. Thorax, 2011, 66(9): 755-763. PMID: 21422039. DOI: 10.1136/thx.2010.152512.
43 Ciprandi G, Tosca MA. Probiotics in children with asthma[J]. Children (Basel), 2022, 9(7): 978. PMID: 35883962. PMCID: PMC9316460. DOI: 10.3390/children9070978.
44 Reddel HK, BacharierLB, Bateman ED, et al. Global initiative for asthma strategy 2021: executive summary and rationale for key changes[J]. Eur Respir J, 2022, 59(1): 2102730. PMID: 34667060. PMCID: PMC8719459. DOI: 10.1183/13993003.02730-2021.
45 Fong I, Zhu J, Finkelstein Y, et al. Antibiotic use in children and youths with asthma: a population-based case-control study[J]. ERJ Open Res, 2021, 7(1): 00944-2020. PMID: 33748257. PMCID: PMC7957291. DOI: 10.1183/23120541.00944-2020.
46 Kelderer F, Mogren I, Eriksson C, et al. Associations between pre- and postnatal antibiotic exposures and early allergic outcomes: a population-based birth cohort study[J]. Pediatr Allergy Immunol, 2022, 33(9): e13848. PMID: 36156813. PMCID: PMC9544930. DOI: 10.1111/pai.13848.
47 LeMessurier KS, Iverson AR, Chang TC, et al. Allergic inflammation alters the lung microbiome and hinders synergistic co-infection with H1N1 influenza virus and Streptococcus pneumoniae in C57BL/6 mice[J]. Sci Rep, 2019, 9(1): 19360. PMID: 31852944. PMCID: PMC6920369. DOI: 10.1038/s41598-019-55712-8.
48 Pollock J, Chalmers JD. The immunomodulatory effects of macrolide antibiotics in respiratory disease[J]. Pulm Pharmacol Ther, 2021, 71: 102095. PMID: 34740749. PMCID: PMC8563091. DOI: 10.1016/j.pupt.2021.102095.
49 Sun J, Li Y. Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases[J]. Pediatr Res, 2022, 91(5): 1036-1042. PMID: 34120139. PMCID: PMC9122820. DOI: 10.1038/s41390-021-01613-4.
50 Hinks TSC, Levine SJ, Brusselle GG. Treatment options in type-2 low asthma[J]. Eur Respir J, 2021, 57(1): 2000528. PMID: 32586877. PMCID: PMC7116624. DOI: 10.1183/13993003.00528-2020.