Drug treatment efficacy in 32 children with streptococcal toxic shock syndrome

ZHANG Hai-Xia; DONG Jie; HUANG Jiao-Tian; ZHANG Ke-Yuan; LU Xiu-Lan; ZHAO Xin; XIAO Chang-Qiong

doi:10.7499/j.issn.1008-8830.2306030

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (9) : 971-975. DOI: 10.7499/j.issn.1008-8830.2306030

CLINICAL RESEARCH

Drug treatment efficacy in 32 children with streptococcal toxic shock syndrome

ZHANG Hai-Xia, DONG Jie, HUANG Jiao-Tian, ZHANG Ke-Yuan, LU Xiu-Lan, ZHAO Xin, XIAO Chang-Qiong

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Abstract

Objective To study the efficacy of different drug treatment regimens in children with streptococcal toxic shock syndrome (STSS). Methods Clinical data of children diagnosed with STSS confirmed by bacterial culture and treated in Hunan Children's Hospital and Chenzhou First People's Hospital from January 2009 to April 2023 were retrospectively collected. The efficacy of different drug treatment regimens was analyzed. The children were divided into four groups based on the treatment regimens: standard group (regimens containing penicillin), Group A (carbapenem + glycopeptides/linezolid), Group B (carbapenems, broad-spectrum antibiotics, glycopeptides/linezolid used alone or in combination, excluding the regimens in Group A), and Group C (macrolides/not receiving antimicrobial drugs). Results A total of 32 cases of STSS were included. Antimicrobial susceptibility testing showed that all strains were sensitive to beta-lactam antibiotics such as ampicillin and vancomycin, while resistant to clindamycin, erythromycin, and tetracycline. There was a statistically significant difference in the efficacy rate among the four groups (P<0.05). The standard group exhibited the highest efficacy rate (100%), while the efficacy rates for Group A, Group B, and Group C were 40%, 40%, and 0%, respectively. Conclusions The use of antimicrobial regimens containing penicillin can improve the therapeutic efficacy of STSS in children.

Key words

Streptococcal toxic shock syndrome / Drug therapy / Efficacy / Child

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ZHANG Hai-Xia, DONG Jie, HUANG Jiao-Tian, ZHANG Ke-Yuan, LU Xiu-Lan, ZHAO Xin, XIAO Chang-Qiong. Drug treatment efficacy in 32 children with streptococcal toxic shock syndrome[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(9): 971-975 https://doi.org/10.7499/j.issn.1008-8830.2306030

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