Neuropsychological development of large for gestational age infants at the age of 12 months

BAO Meng-Yu; QIAO Xiu-Yun; ZHANG Xin-Han; ZHANG Zi-Xuan; ZHAO Fei; CHEN Xin-Xia

doi:10.7499/j.issn.1008-8830.2307040

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (12) : 1246-1252. DOI: 10.7499/j.issn.1008-8830.2307040

CLINICAL RESEARCH

Neuropsychological development of large for gestational age infants at the age of 12 months

BAO Meng-Yu, QIAO Xiu-Yun, ZHANG Xin-Han, ZHANG Zi-Xuan, ZHAO Fei, CHEN Xin-Xia

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Abstract

Objective To investigate the level of neuropsychological development in large for gestational age (LGA) infants at the age of 12 months. Methods The infants, aged 12 to <13 months, who attended the Outpatient Service of Child Care in the First Affiliated Hospital of Shandong First Medical University from December 2021 to June 2023, were enrolled as subjects. According to the gestational age and birth weight, they were divided into preterm appropriate for gestational age (AGA) group, preterm LGA group, early term AGA group, early term LGA group, full-term AGA group, and full-term LGA group. A modified Poisson regression analysis was used to investigate the association between LGA and neuropsychological development outcome at 12 months of age. Results After adjustment for confounding factors, compared with the full-term AGA group at the age of 12 months, the full-term LGA group had a significant increase in the risk of language deficit (RR=1.364, 95%CI: 1.063-1.750), the early term LGA group had significant increases in the risk of abnormal gross motor, fine motor, language, and the preterm LGA group had significant increases in the risk of abnormal language, social behavior, and total developmental quotient (P<0.05); also, the early term AGA group had higher risks of developmental delay across all five attributes and in total developmental quotient at the age of 12 months (P<0.05); except for the language attribute, the preterm AGA group had higher risks of developmental delay in the other 4 attributes (P<0.05). Conclusions The neuropsychological development of LGA infants with different gestational ages lags behind that of full-term AGA infants at 12 months of age, and follow-up and early intervention of such infants should be taken seriously in clinical practice.

Key words

Large for gestational age infant / Neuropsychological development / Preterm infant / Early term infant / Full-term infant

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BAO Meng-Yu, QIAO Xiu-Yun, ZHANG Xin-Han, ZHANG Zi-Xuan, ZHAO Fei, CHEN Xin-Xia. Neuropsychological development of large for gestational age infants at the age of 12 months[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(12): 1246-1252 https://doi.org/10.7499/j.issn.1008-8830.2307040

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