Moxifloxacin treatment for Mycoplasma hominis meningitis in an extremely preterm infant

MAO Wei-Ying; LAN Jiang-Er; GAN Ming-Yu; ZHANG Xun-Jie; YU Hui; HU Li-Yuan; ZHANG Rong; CAO Yun; XIAO Mi-Li

doi:10.7499/j.issn.1008-8830.2312016

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Chinese Journal of Contemporary Pediatrics ›› 2024, Vol. 26 ›› Issue (4) : 432-436. DOI: 10.7499/j.issn.1008-8830.2312016

COLUMN ON DIAGNOSIS & TREATMENT IN MDT MODE

Moxifloxacin treatment for Mycoplasma hominis meningitis in an extremely preterm infant

MAO Wei-Ying, LAN Jiang-Er, GAN Ming-Yu, ZHANG Xun-Jie, YU Hui, HU Li-Yuan, ZHANG Rong, CAO Yun, XIAO Mi-Li

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Abstract

The patient, a male newborn, was admitted to the hospital 2 hours after birth due to prematurity (gestational age 27⁺⁵ weeks) and respiratory distress occurring 2 hours postnatally. After admission, the infant developed fever and elevated C-reactive protein levels. On the fourth day after birth, metagenomic next-generation sequencing of cerebrospinal fluid indicated a positive result for Mycoplasma hominis (9 898 reads). On the eighth day, a retest of cerebrospinal fluid metagenomics confirmed Mycoplasma hominis (56 806 reads). The diagnosis of purulent meningitis caused by Mycoplasma hominis was established, and the antibiotic treatment was switched to moxifloxacin [5 mg/(kg·day)] administered intravenously for a total of 4 weeks. After treatment, the patient's cerebrospinal fluid tests returned to normal, and he was discharged as cured on the 76th day after birth. This article focuses on the diagnosis and treatment of neonatal Mycoplasma hominis purulent meningitis, introducing the multidisciplinary diagnosis and treatment of the condition in extremely preterm infants.

Key words

Purulent meningitis / Mycoplasma hominis / Moxifloxacin / Extremely preterm infant

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MAO Wei-Ying, LAN Jiang-Er, GAN Ming-Yu, ZHANG Xun-Jie, YU Hui, HU Li-Yuan, ZHANG Rong, CAO Yun, XIAO Mi-Li. Moxifloxacin treatment for Mycoplasma hominis meningitis in an extremely preterm infant[J]. Chinese Journal of Contemporary Pediatrics. 2024, 26(4): 432-436 https://doi.org/10.7499/j.issn.1008-8830.2312016

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