Diagnosis of mucormycosis in three children following hematopoietic stem cell transplantation using metagenomic next-generation sequencing

LI Yue; ZHOU Xiao-Hui; WANG Xiao-Dong; WANG Chun-Jing; CAO Ke; LIU Si-Xi

doi:10.7499/j.issn.1008-8830.2408034

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Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (2) : 219-224. DOI: 10.7499/j.issn.1008-8830.2408034

CLINICAL EXPERIENCE

Diagnosis of mucormycosis in three children following hematopoietic stem cell transplantation using metagenomic next-generation sequencing

LI Yue, ZHOU Xiao-Hui, WANG Xiao-Dong, WANG Chun-Jing, CAO Ke, LIU Si-Xi

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Abstract

This article reports the clinical characteristics and treatment processes of three cases of mucormycosis occurring after hematopoietic stem cell transplantation in children, along with a review of relevant literature. All three patients presented with chest pain as the initial symptom, and metagenomic next-generation sequencing (mNGS) confirmed the mucycete infection early in all cases. Two patients recovered after treatment, while one succumbed to disseminated infection. mNGS has facilitated early diagnosis and treatment, reducing mortality rates. Additionally, surgical intervention is an important strategy for improving the prognosis of this condition.

Key words

Mucormycosis / Hematopoietic stem cell transplantation / Metagenomic next-generation sequencing / Child

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LI Yue, ZHOU Xiao-Hui, WANG Xiao-Dong, WANG Chun-Jing, CAO Ke, LIU Si-Xi. Diagnosis of mucormycosis in three children following hematopoietic stem cell transplantation using metagenomic next-generation sequencing[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(2): 219-224 https://doi.org/10.7499/j.issn.1008-8830.2408034

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