Research advances in maturity-onset diabetes of the young

GENG Hui-Yun; WANG Zhi-Hua

doi:10.7499/j.issn.1008-8830.2408070

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Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (1) : 121-126. DOI: 10.7499/j.issn.1008-8830.2408070

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Research advances in maturity-onset diabetes of the young

GENG Hui-Yun, WANG Zhi-Hua

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Abstract

Maturity-onset diabetes of the young (MODY) is a special type of diabetes characterized by clinical features including early onset of diabetes (before 30 years of age), autosomal dominant inheritance, impaired glucose-induced insulin secretion, and hyperglycemia. So far, 14 types of MODY have been reported, accounting for about 1%-5% of the patients with diabetes. MODY often presents with an insidious onset, and although 14 subtypes have been identified for MODY, it is frequently misdiagnosed as type 1 or type 2 diabetes due to overlapping clinical features and high costs and limitations of genetic testing. This article reviews the clinical features of MODY subtypes in order to improve the accuracy of the diagnosis and treatment of MODY.

Key words

Maturity-onset diabetes of the young / Gene mutation / Clinical manifestation / Treatment

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GENG Hui-Yun, WANG Zhi-Hua. Research advances in maturity-onset diabetes of the young[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(1): 121-126 https://doi.org/10.7499/j.issn.1008-8830.2408070

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