Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty

ZHANG Hong-Ru; XIAO Ya; JIANG Shu-Qin; SUN Jun; SHI Wen-Hui; LI Jin-Bo; YANG Ying; WANG Wei

doi:10.7499/j.issn.1008-8830.2411003

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Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (4) : 404-409. DOI: 10.7499/j.issn.1008-8830.2411003

CLINICAL RESEARCH

Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty

ZHANG Hong-Ru, XIAO Ya, JIANG Shu-Qin, SUN Jun, SHI Wen-Hui, LI Jin-Bo, YANG Ying, WANG Wei

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Abstract

Objective To investigate the association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty (ICPP). Methods A retrospective study was conducted involving 61 girls diagnosed with ICPP who visited the pediatric growth and development clinic of the Third Affiliated Hospital of Zhengzhou University between January 2022 and September 2024, designated as the ICPP group, and 61 normally developing girls as the control group. The differences in insulin resistance index (homeostasis model assessment of insulin resistance, HOMA-IR), uterine volume, and other indicators between the two groups were compared, and the relationship between insulin resistance and uterine volume in these girls was analyzed. Results The uterine volume and HOMA-IR level in the ICPP group were significantly higher than those in the control group (P<0.05). Correlation analysis revealed that there was a positive correlation between HOMA-IR level and uterine volume in the ICPP group (r_s=0.643, P<0.001). Multiple linear regression analysis indicated that as HOMA-IR increased,uterine volume in the girls tended to increase (P<0.05). Conclusions There is an association between insulin resistance and uterine volume in girls with ICPP, and as HOMA-IR increases, uterine volume in the girls also increases.

Key words

Idiopathic central precocious puberty / Insulin resistance / Uterine volume / Hypothalamic-pituitary- gonadal axis / Child

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ZHANG Hong-Ru, XIAO Ya, JIANG Shu-Qin, SUN Jun, SHI Wen-Hui, LI Jin-Bo, YANG Ying, WANG Wei. Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(4): 404-409 https://doi.org/10.7499/j.issn.1008-8830.2411003

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